利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.013 秒)

    PROCESS FOR THE PREPARATION OF 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-IMIDAZOLE-5-CARBOXYLATES
    4.
    发明公开
    PROCESS FOR THE PREPARATION OF 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-IMIDAZOLE-5-CARBOXYLATES 有权
    VERFAHREN ZUR HERSTELLUNG VON 4-（1-羟基-1-甲基乙基）-2-丙氧基咪唑-5-羧酸酯

    公开(公告)号：EP2374799A1

    公开(公告)日：2011-10-12

    申请号：EP08878075.4

    申请日：2008-11-17

    申请人： Shanghai Institute of Pharmaceutical Industry ,  Zhejiang Hisun Pharmaceutical Co. Ltd.

    发明人： ZHANG, Fuli ,  WU, Taizhi ,  XIE, Meihua

    IPC分类号： C07D233/90 ,  C07D491/048

    CPC分类号： C07D233/90 ,  C07D491/048

    摘要： The present invention discloses a process for obtaining 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate (formula I) by the reaction of 4,4-dimethyl-2-propyl-4,6-dihydrofuro[3,4-d]imidazole (formula II), or its hydrolysis product, or its ring-opening product, with alcohol under appropriate catalytic conditions. Furthermore, the present invention also provides a process for obtaining high purity 4,4-dimethyl-2-propyl-4,6-dihydrofuro[3,4-d]imidazole (formula II), therefore purified compound of formula I can be produced. Producing of olmesartan medoxomil at high purity is assured by said processes. R in formula I is selected from C 1 -C 6 alkyl.

    摘要翻译： 本发明公开了4-（1-羟基-1-甲基乙基）-2-丙基 - 咪唑-5-羧酸酯（式I）的方法，通过4,4-二甲基-2-丙基-4,6 - 二氢呋喃并[3,4-d]咪唑（式II）或其水解产物或其开环产物与醇在合适的催化条件下反应。 此外，本发明还提供了获得高纯度4,4-二甲基-2-丙基-4,6-二氢呋喃并[3,4-d]咪唑（式II）的方法，因此可以制备纯化的式I化合物 。 通过所述方法可以保证高纯度的奥美沙坦酯的生产。 式I中的R选自C 1 -C 6烷基。