公开(公告)号：EP4458806A1

公开(公告)日：2024-11-06

申请号：EP22914988.5

申请日：2022-12-29

申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd. ,  Shanghai Senhui Medicine Co., Ltd. ,  Shanghai Shengdi Pharmaceutical Co., Ltd

发明人： ZHU, Lingjian ,  SHI, Jianyu ,  LIU, Chongyi ,  JIANG, Jun ,  HUANG, Jian

IPC分类号： C07C229/12 ,  C07C229/16 ,  C07C217/08 ,  A61K31/7088 ,  A61K47/18 ,  A61K9/127

摘要： Provided are a lipid and a composition used for delivery. Specifically provided is a compound represented by formula I or a salt thereof, wherein R 1 to R 3 , H 1 to H 3 , L 1 , and L 2 are as defined in the description.

公开(公告)号：EP4293032A1

公开(公告)日：2023-12-20

申请号：EP22752320.6

申请日：2022-02-10

申请人： Shanghai Senhui Medicine Co., Ltd. ,  Shanghai Shengdi Pharmaceutical Co., Ltd ,  Jiangsu Hengrui Pharmaceuticals Co., Ltd.

发明人： ZHU, Lingjian ,  SHI, Jianyu ,  JI, Changjin ,  DONG, Bangjie ,  HUANG, Jian

IPC分类号： C07F9/553 ,  A61K31/675 ,  A61P7/02 ,  A61P9/12 ,  A61P9/14

摘要： Benzazepine compounds, a preparation method therefor and pharmaceutical use thereof. Specifically, the present invention relates to a compound represented by formula II-1 or formula VIII-1, a pharmaceutical composition containing same, and pharmaceutical use thereof. The benzazepine compounds can be used for treating diseases associated with vasopressin receptors, in particular hypertension, heart disease, etc.