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公开(公告)号：EP4458806A1
公开(公告)日：2024-11-06
申请号：EP22914988.5
申请日：2022-12-29
申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd. , Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd
发明人： ZHU, Lingjian , SHI, Jianyu , LIU, Chongyi , JIANG, Jun , HUANG, Jian
IPC分类号： C07C229/12 , C07C229/16 , C07C217/08 , A61K31/7088 , A61K47/18 , A61K9/127
摘要： Provided are a lipid and a composition used for delivery. Specifically provided is a compound represented by formula I or a salt thereof, wherein R 1 to R 3 , H 1 to H 3 , L 1 , and L 2 are as defined in the description.
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公开(公告)号：EP4183774A1
公开(公告)日：2023-05-24
申请号：EP21842032.1
申请日：2021-07-16
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： HUANG, Jian , ZHU, Lingjian , YU, Xiuzhao , SUN, Piaoyang
IPC分类号： C07C311/59 , A61K31/64
摘要： The present invention relates to a sulfonylurea derivative and medical uses thereof, specifically relating to the sulfonylurea derivative shown in general formula (I), a preparation method thereof, a pharmaceutical composition containing same, and a use of same for treating diseases and disorders affected by neuronal damage, for example: cerebral stroke, brain damage, neuropathic pain, migraines, inflammatory pain, chronic pain, or depression. The definition of each group in the general formula (I) is the same as that in the description.
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公开(公告)号：EP4144742A1
公开(公告)日：2023-03-08
申请号：EP21796822.1
申请日：2021-04-30
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： ZHANG, Lianshan , HUANG, Jian , ZHU, Lingjian , TANG, Yinggang , HUANG, Qi , MENG, Jia
IPC分类号： C07F9/09 , A61K31/683 , A61P9/14
摘要： Involved are an inositol derivative and a use thereof. Specifically, provided is a compound, said compound includes two or many parts, as represented by formula (D), connected via a common central linker L2, where formula (D) is as shown below.
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公开(公告)号：EP4293032A1
公开(公告)日：2023-12-20
申请号：EP22752320.6
申请日：2022-02-10
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： ZHU, Lingjian , SHI, Jianyu , JI, Changjin , DONG, Bangjie , HUANG, Jian
IPC分类号： C07F9/553 , A61K31/675 , A61P7/02 , A61P9/12 , A61P9/14
摘要： Benzazepine compounds, a preparation method therefor and pharmaceutical use thereof. Specifically, the present invention relates to a compound represented by formula II-1 or formula VIII-1, a pharmaceutical composition containing same, and pharmaceutical use thereof. The benzazepine compounds can be used for treating diseases associated with vasopressin receptors, in particular hypertension, heart disease, etc.
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公开(公告)号：EP4205767A1
公开(公告)日：2023-07-05
申请号：EP21860418.9
申请日：2021-08-25
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： HUANG, Jian , ZHU, Lingjian , GUAN, Zhongjun , LIANG, Shaonan , REN, Wenming , LIAO, Cheng
摘要： A drug-loaded macromolecule and a preparation method therefor, the macromolecule specifically being a dentritic polymer loaded with a drug and a pharmacokinetic modifier, and relating in particular to connecting the drug to the dentritic polymer by means of a specific linker. The present macromolecule can be used to regulate the release speed of the drug, specifically by means of the selection of linker.
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公开(公告)号：EP4279491A1
公开(公告)日：2023-11-22
申请号：EP22739024.2
申请日：2022-01-12
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： HUANG, Jian , ZHU, Lingjian , ZOU, Yang , ZHANG, Cili
IPC分类号： C07D501/46 , A61K31/546 , A61P31/04
摘要： The present disclosure relates to a cephalosporin antibacterial compound and a preparation method therefor. The cephalosporin antibacterial compound can exhibit antibacterial activity against Gram-negative bacteria and other bacteria.
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公开(公告)号：EP4095141A1
公开(公告)日：2022-11-30
申请号：EP21745090.7
申请日：2021-01-22
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： HUANG, Jian , ZHU, Lingjian , ZOU, Yang , ZHANG, Cili
IPC分类号： C07D501/46 , A61K31/546 , A61P31/04
摘要： Provided are a cephalosporin compound represented by formula 1-1, 1-2, or 1-3, a pharmaceutical composition comprising same, and use thereof as an antibacterial agent.
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公开(公告)号：EP4293028A1
公开(公告)日：2023-12-20
申请号：EP22752311.5
申请日：2022-02-10
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： ZHU, Lingjian , YU, Xiuzhao , LIU, Xiaowu , BEN, Peipei , CHEN, Lei , KONG, Xianglin , HUANG, Jian , SUN, Piaoyang
IPC分类号： C07D519/00 , A61K31/407 , A61P7/02 , A61P9/10
摘要： The present disclosure relates to an SMTP-7 derivative and the use thereof. In particular, provided is a compound as represented by formula I or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description.
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9.发明公开
公开(公告)号：EP4289857A1
公开(公告)日：2023-12-13
申请号：EP22749058.8
申请日：2022-01-28
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： ZHU, Lingjian , HONG, Min , TANG, Manping , SU, Lu , DENG, Mengdie , ZHANG, Jingyang , REN, Wenming , LIN, Kan , HUANG, Jian , LIAO, Cheng , ZHANG, Lianshan
摘要： A drug conjugate of a glucocorticoid receptor agonist, and an application thereof in medicine. Specifically, the present invention relates to an antibody-drug conjugate as represented by formula (I): Ab-(L-D)k (I), wherein Ab is an antibody or an antigen-binding fragment thereof, L is a linker covalently linking Ab to D, k is 1 to 20, and D is as represented by formula (II-A) or (II-B). The groups in the formulas are as defined in the description. The antibody-drug conjugate can effectively treat autoimmune diseases.
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10.发明公开
公开(公告)号：EP4094779A1
公开(公告)日：2022-11-30
申请号：EP21744595.6
申请日：2021-01-22
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Shanghai Hengrui Pharmaceutical Co., Ltd. , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： HUANG, Jian , ZHU, Lingjian , YU, Xiuzhao , ZHU, Bo , REN, Wenming , TANG, Mi , SUN, Xing , YANG, Yang , LIANG, Jindong , HU, Qiyue
IPC分类号： A61K47/68 , C07D307/20 , C07K16/28 , A61P35/00
摘要： The present disclosure relates to a drug conjugate of an Eribulin derivative, a preparation method therefor and an application thereof in medicine. Specifically, provided is an antibody-drug conjugate, which contains an Eribulin derivative drug portion. The present disclosure further relates to a method for treating cancer by administering the antibody-drug conjugate provided herein.
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