公开(公告)号：EP3950676A1

公开(公告)日：2022-02-09

申请号：EP20778681.5

申请日：2020-03-24

申请人： Shanghai Synergy Pharmaceutical Sciences Co., Ltd ,  Zhejiang Huahai Pharmaceutical Co., Ltd.

发明人： XU, Xin ,  CHEN, Jia ,  ZHANG, Zhen ,  ZHANG, Liming ,  WU, Qimei ,  JIANG, Qingyun ,  GUO, Fengying ,  ZHANG, Yuyun ,  YU, Hao ,  WANG, Ying ,  SUN, Kang ,  ZANG, Chengxu ,  QIN, Chenggang ,  ZHOU, Xiaobo ,  ZHANG, Xiaojuan ,  WANG, Yijin ,  XIA, Xiaoer ,  LI, Yunfei ,  GE, Jian

IPC分类号： C07D213/64 ,  C07D401/14 ,  C07D401/12 ,  C07D405/12 ,  A61K31/4412 ,  A61K31/4433 ,  A61K31/444 ,  A61P35/00 ,  A61P35/02

摘要： The present invention relates to a preparation method for an amide compound and an application thereof in the field of medicine. Specifically, provided by the present invention is an amide small molecule compound which is an inhibitor of Zeste gene enhancer homolog 2 (EZH2) and which may be used to prevent and /or treat EZH2-mediated related diseases, comprising tumors, myeloproliferative diseases or autoimmune diseases.