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    WHOLE NEW IMMUNOASSAY MODE FOR DETERMINING TOTAL ANTIBODY
    2.
    发明公开
    WHOLE NEW IMMUNOASSAY MODE FOR DETERMINING TOTAL ANTIBODY 审中-公开

    公开(公告)号：EP4016080A1

    公开(公告)日：2022-06-22

    申请号：EP19942193.4

    申请日：2019-08-16

    申请人： Shenzhen Mindray Bio-Medical Electronics Co., Ltd.

    发明人： WANG, Di ,  HE, Jianwen ,  XIA, Ying

    IPC分类号： G01N33/536 ,  G01N33/543 ,  G01N33/569

    摘要： Disclosed are a novel immunoassay format design for determining a total antibody, and a kit accordingly provided for detecting antibodies of a pathogen or pathogens of infectious diseases within a human blood sample, wherein the kit comprises: a first reagent containing at least one antigen coated on a solid phase support and an anti-human IgM antibody coated on a solid phase support; and a second reagent containing at least one labelled antigen and a labelled anti-human IgG antibody, wherein at least one antigen of the at least one antigen coated on a solid phase support and at least one antigen of the at least one labelled antigen can bind to the same IgG antibody or the same IgM antibody in the sample. The kit can overcome the disadvantages caused by detection principles while retaining the advantages of each detection principle. In addition, also provided is a new method for detecting an antibody produced after the infection of a pathogen or pathogens in a sample.

    KIT AND METHOD FOR MIXED DETECTION OF PCT AND PRESEPSIN, AND USE THEREOF
    4.
    发明公开
    KIT AND METHOD FOR MIXED DETECTION OF PCT AND PRESEPSIN, AND USE THEREOF 审中-公开

    公开(公告)号：EP4060338A1

    公开(公告)日：2022-09-21

    申请号：EP19953055.1

    申请日：2019-11-19

    申请人： Shenzhen Mindray Bio-Medical Electronics Co., Ltd

    发明人： YU, Lina ,  LI, Ke ,  HE, Jianwen

    IPC分类号： G01N33/53 ,  C07K16/28 ,  C07K7/00

    摘要： A kit and a method for combined detection of PCT and Presepsin in a sample to be tested, and use thereof. The kit comprises: a capture antibody mixture, the capture antibody mixture comprising a procalcitonin capture antibody coated on a solid phase and a soluble CD14 subtype capture antibody coated on a solid phase; and a detection antibody mixture, the detection antibody mixture comprising a labeled procalcitonin detection antibody and a labeled soluble CD14 subtype detection antibody. The kit, method and use thereof can detect a combined signal value of PCT and Presepsin in a sample in a reaction system, the comparison between the combined signal value and a reference value can be used for evaluating the possibility of a patient suffering from sepsis and evaluating the prognosis of a suspected sepsis patient, and compared with detecting PCT or Presepsin in a sample alone, a more efficient diagnosis and a better prognostic power are provided.