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公开(公告)号：EP4092051A1
公开(公告)日：2022-11-23
申请号：EP20940651.1
申请日：2020-06-18
发明人： YU, Lina , LI, Ke , HE, Jianwen
IPC分类号： C07K16/28 , C12N15/06 , C12N5/10 , A61K39/395
摘要： An anti-soluble CD14 subtype monoclonal antibody or an antigen-binding antibody fragment thereof specifically recognizes an epitope composed of the amino acid sequence of SEQ ID No. 84. A kit for detecting the soluble CD14 subtype, a method for detecting the soluble CD14 subtype and corresponding use.
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公开(公告)号：EP4394016A1
公开(公告)日：2024-07-03
申请号：EP23220786.0
申请日：2023-12-29
发明人： WANG, Junlin , ZHAN, Chengxiong , LI, Ke
IPC分类号： C09K11/07 , G01N33/533
摘要： The disclosure relates to a chemiluminescent substrate solution, a chemiluminescence enhancer and the use thereof. The chemiluminescent substrate solution comprises a chemiluminescent substrate and a chemiluminescence enhancer, the chemiluminescence enhancer comprised a fluorescent agent and a surfactant, the fluorescent agent comprises one or more of carboxyfluoresceins selected from compounds represented by general formula I. The disclosure further relates to the use of a carboxyfluorescein in enhancing chemiluminescence of a dioxetane derivative catalyzed by alkaline phosphatase.
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公开(公告)号：EP4060338A1
公开(公告)日：2022-09-21
申请号：EP19953055.1
申请日：2019-11-19
发明人： YU, Lina , LI, Ke , HE, Jianwen
摘要： A kit and a method for combined detection of PCT and Presepsin in a sample to be tested, and use thereof. The kit comprises: a capture antibody mixture, the capture antibody mixture comprising a procalcitonin capture antibody coated on a solid phase and a soluble CD14 subtype capture antibody coated on a solid phase; and a detection antibody mixture, the detection antibody mixture comprising a labeled procalcitonin detection antibody and a labeled soluble CD14 subtype detection antibody. The kit, method and use thereof can detect a combined signal value of PCT and Presepsin in a sample in a reaction system, the comparison between the combined signal value and a reference value can be used for evaluating the possibility of a patient suffering from sepsis and evaluating the prognosis of a suspected sepsis patient, and compared with detecting PCT or Presepsin in a sample alone, a more efficient diagnosis and a better prognostic power are provided.
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公开(公告)号：EP4059517A1
公开(公告)日：2022-09-21
申请号：EP19953573.3
申请日：2019-11-19
发明人： YU, Lina , LI, Ke , HE, Jianwen
IPC分类号： A61K39/395 , C07K16/28
摘要： The present invention relates to an anti-soluble CD 14 subtype monoclonal antibody or an antigen-binding antibody fragment thereof, which specifically recognize an epitope composed of the amino acid sequence of SEQ ID No. 42. The present invention also relates to a kit for detecting a soluble CD 14 subtype, a method for detecting a soluble CD 14 subtype, and the corresponding use thereof.
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公开(公告)号：EP4047369A1
公开(公告)日：2022-08-24
申请号：EP19949154.9
申请日：2019-10-14
发明人： LI, Ke , JIANG, Ming , HE, Jianwen , ZHANG, Yuping
IPC分类号： G01N33/569 , G01N33/576 , G01N33/543 , G01N33/68 , G01N21/76
摘要： The present application provides a kit for detecting a hepatitis C virus (HCV), comprising a fusion protein of an enzyme for labelling and an HCV antigenic protein, wherein the antigenic protein contains one or more of HCV core antigen, HCV NS3 antigen, HCV NS4 antigen, and HCV NS5 antigen, or a fusion antigen of two or more of the antigens. The present application further provides a corresponding method for detecting an antibody in a sample produced after being infected with HCV
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