公开(公告)号：EP3287443A1

公开(公告)日：2018-02-28

申请号：EP16783270.8

申请日：2016-04-22

申请人： Shionogi & Co., Ltd

发明人： TANAKA, Satoru ,  OGAWA, Tomoyuki ,  KAI, Hiroyuki ,  OGATA, Yuki ,  HIRAI, Keiichiro ,  KUROSE, Noriyuki ,  FUJII, Yasuhiko

IPC分类号： C07D213/69 ,  A61K31/4412 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P3/10 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P13/00 ,  A61P13/08 ,  A61P13/10 ,  A61P13/12 ,  A61P17/02

CPC分类号： C07D239/52 ,  A61K31/4412 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  C07D213/69 ,  C07D213/74 ,  C07D239/47 ,  C07D239/48 ,  C07D239/54 ,  C07D239/545 ,  C07D239/60 ,  C07D253/06 ,  C07D253/075 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： A compound represented by Formula (I):

wherein

or the like
Y 1 is O or the like; Z 1 is C(R 4 ) or N; Z 2a is C(R 5a ) or the like; Z 3a is C(R 6 ) or the like;
R 4 , R 5a and R 6 are each independently a hydrogen atom or the like; R 1 is substituted or unsubstituted aromatic carbocyclyl or the like; R 2a , R 2b , R 2c and R 2d are each independently a hydrogen atom or the like; X is N(R 7a ) or the like; R 7a is a hydrogen atom or the like; R 3 is

or the like
Ring B is a 6-membered aromatic carbocycle or the like; R 9a and R 10a are each independently halogen or the like; n is an integer from 1 to 5; m is an integer from 0 to 4; and p1 is an integer from 0 to 3,
or a pharmaceutically acceptable salt thereof.

摘要翻译： 由式（I）表示的化合物或其类似物Y1是O等; Z1是C（R4）或N; Z2a是C（R5a）等; Z3a是C（R6）等; R4，R5a和R6各自独立地为氢原子等; R1是取代或未取代的芳族碳环基等; R2a，R2b，R2c和R2d各自独立地为氢原子等; X是N（R7a）等; R7a是氢原子等; R3是或类似的环B是6元芳香碳环等; R9a和R10a各自独立地为卤素等; n是1至5的整数; m是0至4的整数; 且p1是0至3的整数，或其药学上可接受的盐。

公开(公告)号：EP3156410A1

公开(公告)日：2017-04-19

申请号：EP15805780.2

申请日：2015-06-12

申请人： SHIONOGI & CO., LTD.

发明人： MIYAZAKI, Keisuke ,  TAKAYA, Kenji ,  OHARA, Takafumi ,  SUGIMOTO, Hideki ,  FUJITANI, Manabu ,  OGATA, Yuki ,  SUZUKI, Naoyuki

IPC分类号： C07H17/08 ,  A61K31/357 ,  A61P31/10

CPC分类号： C07H17/08 ,  C07H1/00 ,  C07H23/00

摘要： The present invention is the following Amphotericin B derivative:

wherein each symbol is defined in description. The compound of the present invention has 16th position (X) is urea structure, cyclic structure, hydroxyalkyl or substituted monoalkylcarbamoyl. The compound of the present invention has antifungal activity.

摘要翻译： 本发明是以下两性霉素B衍生物：其中每个符号在描述中定义。 本发明的化合物具有第16位（X）是脲结构，环状结构，羟基烷基或取代的单烷基氨基甲酰基。 本发明的化合物具有抗真菌活性。