公开(公告)号：EP1384777B1

公开(公告)日：2009-05-27

申请号：EP02713262.0

申请日：2002-03-29

申请人： Shiozawa, Shunichi

发明人： SHIOZAWA, Shunichi ,  KOMAI, Koichiro ,  YAGI, Hirofumi ,  MATSUURA, Nao

IPC分类号： C12N15/09 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/50

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： Genomic DNAs derived from the genomic DNA represented by SEQ ID NO:1 by at least one of the following variations; a method of diagnosing human rheumatoid arthritis by using these variations; a method of judging the onset risk thereof; and a diagnostic kit for detecting the same: (1) substitution of cytosine (c) at the 1987-position into thymine (t); (2) substitution of thymine (t) at the 3664-position into guanine (g); and (3) substitution of adenine (a) at the 3769-position into cytosine (c).

公开(公告)号：EP1384777A1

公开(公告)日：2004-01-28

申请号：EP02713262.0

申请日：2002-03-29

申请人： Shiozawa, Shunichi

发明人： SHIOZAWA, Shunichi ,  KOMAI, Koichiro ,  YAGI, Hirofumi ,  MATSUURA, Nao

IPC分类号： C12N15/09 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/50

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： A genomic DNA involved in rheumatoid arthritis, a method of diagnosing rheumatoid arthritis or a method of judging onset risk of rheumatoid arthritis, and a diagnostic kit for diagnosing rheumatoid arthritis or judging onset risk of rheumatoid arthritis, which genomic DNA comprises at least one of the following mutations in genomic DNA consisting of the base sequence of SEQ ID NO: 1:

(1) substitution of thymine (t) for cytosine (c) at the position-1987;
(2) substitution of guanine (g) for thymine (t) at the position-3664; and
(3) substitution of cytosine (c) for adenine (a) at the position-3769.

摘要翻译： 在类风湿性关节炎中涉及的基因组DNA，诊断类风湿关节炎或判断类风湿性关节炎的发病风险的方法的方法，以及用于诊断类风湿性关节炎或判断类风湿性关节炎，哪些基因组DNA包含的所述至少一个的发病风险的诊断试剂盒 在基因组DNA以下突变由SEQ ID NO：1的碱基序列的1：（1）胸腺嘧啶（T），用于在位置1987胞嘧啶（c）的取代基; （2）鸟嘌呤（G），用于在位置3664胸腺嘧啶（T）取代; 和（3）的胞嘧啶（c）中为腺嘌呤的取代（a）在所述位置第三千七百六十九