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1.发明公开Cell mass capable of serving as a primitive organ-like structure comprised of a plurality of cell types of somatic origin 有权Zellcluster mit mehreren Zellarten aus dem Soma mitFähigkeitzur Bildung primitiverorganähnlicherStrukturen
公开(公告)号：EP2455111A3
公开(公告)日：2012-06-13
申请号：EP12155498.4
申请日：2007-06-27
CPC分类号： C12N5/0697 , C12N5/0625 , C12N5/0627 , C12N5/0629 , C12N5/0666 , C12N2501/40 , C12N2501/415
摘要： The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures followed by adding a Wnt signal activator to the mixed cell culture; subjecting the culture containing the Wnt signal activator to non-plate contact culturing over a predetermined time period; and replacing the medium of the culture cultured by the non-plate contact culturing with medium not containing Wnt signal activator and further culturing for a predetermined time period; wherein, at least one type of the plurality of somatic cells is maintained in an undifferentiated state.
摘要翻译： 本发明提供一种制备能够作为由体细胞起源的多种体细胞类型构成的原始器官状结构的细胞团的方法，其包括：制备含有多种类型体细胞的培养物; 混合多种类型的体细胞培养物，然后向混合细胞培养物中加入Wnt信号激活剂; 使含有Wnt信号激活剂的培养物在预定时间段内进行非平板接触培养; 并用不含Wnt信号激活剂的培养基替换由非板接触培养培养的培养基，并进一步培养预定时间段; 其中，至少一种类型的所述多个体细胞维持在未分化状态。
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2.发明公开Hair resiliency / body improver and hair cosmetic 审中-公开Mittel zur Verbesserung derHaarelastizität/ desKörpersund Haarkosmetika
公开(公告)号：EP2484342A1
公开(公告)日：2012-08-08
申请号：EP12154575.0
申请日：2006-07-21
IPC分类号： A61K8/49 , A61Q5/00 , C07D277/20 , C07D277/40 , C07D277/46 , A61Q7/00 , A61Q5/12
摘要： A hair resiliency and body improver comprising as the active ingredient thereof one or more types of compounds selected from the group consisting of 2-aminothiazole derivatives represented by the following general formula (1) or 3-aminoisoxazole derivatives represented by the following general formula (2), and pharmaceutically acceptable salts thereof:
(wherein, R 1 , R 2 , R 3 , R 4 , n and m are as defined in the description).摘要翻译： 一种头发弹性和身体改良剂，其包含选自由以下通式（1）表示的2-氨基噻唑衍生物或由下列通式（2）表示的3-氨基异恶唑衍生物组成的组中的一种或多种化合物作为其活性成分： ）及其药学上可接受的盐：（其中，R 1，R 2，R 3，R 4，n和m如说明书中所定义）。
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3.发明公开Cell mass capable of serving as a primitive organ-like structure comprised of a plurality of cell types of somatic origin 有权ZELLCLUSTER MIT MEHREREN ZELLARTEN AUS DEM SOMA MITFÄHIGKEITZUR BILDUNG PRIMITIVERORGANÄHNLICHERSTRUKTUREN
公开(公告)号：EP2455111A2
公开(公告)日：2012-05-23
申请号：EP12155498.4
申请日：2007-06-27
CPC分类号： C12N5/0697 , C12N5/0625 , C12N5/0627 , C12N5/0629 , C12N5/0666 , C12N2501/40 , C12N2501/415
摘要： The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures followed by adding a Wnt signal activator to the mixed cell culture; subjecting the culture containing the Wnt signal activator to non-plate contact culturing over a predetermined time period; and replacing the medium of the culture cultured by the non-plate contact culturing with medium not containing Wnt signal activator and further culturing for a predetermined time period; wherein, at least one type of the plurality of somatic cells is maintained in an undifferentiated state.
摘要翻译： 本发明提供一种制备能够作为由体细胞起源的多种体细胞类型构成的原始器官状结构的细胞团的方法，其包括：制备含有多种类型体细胞的培养物; 混合多种类型的体细胞培养物，然后向混合细胞培养物中加入Wnt信号激活剂; 使含有Wnt信号激活剂的培养物在预定时间段内进行非平板接触培养; 并用不含Wnt信号激活剂的培养基替换由非板接触培养培养的培养基，并进一步培养预定时间段; 其中，至少一种类型的所述多个体细胞维持在未分化状态。
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