公开(公告)号：EP3426769B1

公开(公告)日：2024-09-25

申请号：EP17715816.9

申请日：2017-03-09

IPC: C12N5/071 ,  B01L3/00

CPC classification number: C12N5/0697 ,  C12N2506/139220130101 ,  C12N2513/0020130101 ,  C12N2531/0020130101 ,  C12N2533/9020130101 ,  C12N2506/2320130101 ,  B01L2300/081620130101 ,  B01L2300/08920130101 ,  B01L2300/16120130101 ,  B01L2300/16320130101 ,  B01L2400/045720130101 ,  B01L3/502761

公开(公告)号：EP4423255A1

公开(公告)日：2024-09-04

申请号：EP22797831.9

申请日：2022-10-25

Applicant: Carcinotech Ltd

Inventor： MALHOTRA, Ishani

IPC: C12N5/09 ,  A61P35/00 ,  C12N5/095 ,  G01N33/50 ,  G01N33/574 ,  C12N5/079 ,  C12N5/071 ,  A61B17/00

CPC classification number: A61P35/00 ,  C12N5/0693 ,  C12N5/0695 ,  C12N5/0622 ,  C12N5/0697 ,  C12N2513/0020130101 ,  G01N33/5082 ,  G01N2800/702820130101

公开(公告)号：EP3985107B1

公开(公告)日：2024-06-19

申请号：EP21192918.7

申请日：2017-07-31

IPC: C12N5/0793 ,  C12N5/079 ,  C12N5/071 ,  G01N33/50 ,  C12N5/00 ,  C12M1/12 ,  C12M1/42

CPC classification number: C12N5/0062 ,  C12N5/0622 ,  C12N5/069 ,  C12N5/0691 ,  C12N5/0697 ,  G01N33/5058 ,  C12N2502/08120130101 ,  C12N2502/2820130101 ,  C12N2503/0220130101 ,  C12N2503/0420130101 ,  C12N2533/3020130101 ,  C12N2533/5220130101 ,  C12M25/14 ,  C12M35/08 ,  C12M25/04

公开(公告)号：EP2970896B1

公开(公告)日：2024-04-24

申请号：EP14769577.9

申请日：2014-03-13

IPC: G01N33/50 ,  A61P1/16 ,  C12N5/071 ,  C12N5/077

CPC classification number: G01N33/5088 ,  C12N5/0671 ,  C12N2533/3020130101 ,  C12N2535/1020130101 ,  C12N2502/1420130101 ,  C12N2502/2820130101 ,  C12N5/0656 ,  C12N5/0697 ,  A61P1/16

公开(公告)号：EP2585171B1

公开(公告)日：2018-12-26

申请号：EP11772857.6

申请日：2011-05-06

Applicant: University Of Central Florida Research Foundation, Inc.

Inventor： HICKMAN, James ,  GUO, Xiufang

IPC: A61P21/00 ,  C12N5/079 ,  C12N5/077

CPC classification number: G01N33/5058 ,  C12N5/0697 ,  C12N2500/90 ,  C12N2501/01 ,  C12N2501/105 ,  C12N2501/13 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2501/58 ,  C12N2502/081 ,  C12N2502/1335 ,  C12N2533/20 ,  C12N2535/10 ,  G01N33/48728 ,  G01N33/6872 ,  G01N33/6887 ,  G01N2500/10

Abstract: A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more rat muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a rat muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions.

公开(公告)号：EP3395942A1

公开(公告)日：2018-10-31

申请号：EP17168051.5

申请日：2017-04-25

Applicant: IMBA-Institut für Molekulare Biotechnologie GmbH

Inventor： KNOBLICH, Jürgen A. ,  BAGLEY, Joshua A.

IPC: C12N5/071 ,  C12N5/079

CPC classification number: C12N5/0697 ,  C12N5/0618 ,  C12N2500/99 ,  C12N2501/115 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2510/00 ,  C12N2533/54

Abstract: The present invention relates to an in vitro method of producing a bi- or multi-differentiated tissue with at least two tissue types comprising the steps of developing a first tissue to a stage of differentiation of interest, developing a second tissue to a stage of differentiation of interest differing from the stage of differentiation of interest of the first tissue, placing said first and second tissue in a vicinity sufficient for fusion by growth, allowing the first and second tissue to grow and fuse to each other, thereby producing a bi- or multi-differentiated tissue comprising the first and second tissue with different stages of differentiation ; bi- or multi-differentiated tissue obtained by such a method; uses of the tissue and kits for performing the method.

公开(公告)号：EP3204488A4

公开(公告)日：2018-03-21

申请号：EP15848294

申请日：2015-10-06

Applicant: ORGANOVO INC

Inventor： NGUYEN DEBORAH LYNN GREENE ,  KING SHELBY MARIE ,  PRESNELL SHARON C

IPC: C12N5/071 ,  G01N33/50

CPC classification number: G01N33/5014 ,  C12N5/0684 ,  C12N5/0697 ,  C12N2502/1323 ,  C12N2502/256 ,  C12N2502/28 ,  G01N33/5044 ,  G01N2500/02 ,  G01N2500/10

Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.

公开(公告)号：EP3187580A4

公开(公告)日：2018-02-21

申请号：EP15835587

申请日：2015-08-25

Applicant: UNIV HIROSAKI ,  UNIV OSAKA

Inventor： SHIMODA HIROSHI ,  ASANO YOSHIYA ,  AKASHI MITSURU ,  MATSUSAKI MICHIYA

IPC: C12N5/071 ,  C12N11/02

CPC classification number: C12N5/0697 ,  C12N11/02 ,  C12N2502/1192 ,  C12N2502/1323 ,  C12N2502/28 ,  C12N2513/00 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90

Abstract: The present disclosure relates to: an artificial peritoneal tissue comprising a cellular tissue and a mesothelial cell layer that covers the surface of the cellular tissue, wherein the cellular tissue comprises a fibroblast, an extracellular matrix, and a vascular endothelial cell and/or a lymphatic endothelial cell each capable of forming a lumen; and a method for producing the artificial peritoneal tissue.

公开(公告)号：EP3140394A4

公开(公告)日：2017-12-27

申请号：EP15789527

申请日：2015-05-05

Applicant: NAT UNIV SINGAPORE ,  AGENCY FOR SCIENCE TECH AND RESEARCH

Inventor： BENNY PAULA-BETH ANGELICA TIQUI ,  RAGHUNATH MICHAEL ,  LANE ELLEN BIRGITTE ,  BADOWSKI CEDRIC

IPC: C12N5/071 ,  A61L27/20 ,  A61L27/36 ,  A61L27/38 ,  A61L27/52 ,  C12N1/38

CPC classification number: A61L27/52 ,  A61L27/20 ,  A61L27/3633 ,  A61L27/3804 ,  A61L27/3813 ,  C12N5/0697 ,  C12N2502/094 ,  C12N2533/74 ,  C12N2533/76 ,  C12N2533/90 ,  C08L5/12 ,  C08L5/04

Abstract: The present invention relates, in various embodiments, to methods of producing a tissue-mimetic construct having a basement membrane, methods of producing an acellular scaffold containing an extracellular matrix (ECM), methods of producing a scaffold comprising a hydrogel that is enriched in ECM components, methods of treating a condition in a subject in need thereof with a tissue-mimetic construct having a basement membrane, and methods of assessing whether an agent is suitable for administering to a tissue. The invention further relates to tissue-mimetic constructs and scaffolds produced in accordance with the methods of the invention.

公开(公告)号：EP2889374B1

公开(公告)日：2017-12-13

申请号：EP13830548.7

申请日：2013-08-23

Applicant: RIKEN

Inventor： TAKAHASHI, Masayo ,  KAMAO, Hiroyuki

IPC: C12N5/10 ,  A61K35/44 ,  A61L27/00 ,  A61P27/02 ,  C12N5/071 ,  A61L27/50 ,  G09B23/28 ,  A61L27/38 ,  C12N5/079

CPC classification number: A61K35/44 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3891 ,  A61L2430/16 ,  C12N5/0621 ,  C12N5/069 ,  C12N5/0697 ,  C12N2502/085 ,  C12N2502/28 ,  C12N2509/00 ,  C12N2533/54

Abstract: The present invention provides a method of producing a cell sheet comprising a retinal pigment epithelial cell layer and a vascular forming cell layer composed of stem cells having vascular formation ability or blood vessel constituting cells, comprising a step of laminating the retinal pigment epithelial cell layer and the vascular forming cell layer, and a cell sheet obtained by said method. Furthermore, the present invention provides a cell sheet for transplantation, comprising a cell layer formed with retinal pigment epithelial cells obtained by inducing differentiation of stem cells or progenitor cells ex vivo, a basement membrane secreted from said cells, and a vascular forming cell layer composed of stem cells having vascular formation ability or blood vessel constituting cells.