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公开(公告)号：EP4316475A1
公开(公告)日：2024-02-07
申请号：EP22775501.4
申请日：2022-03-18
发明人： TOJYO, Moe , KAJIYA, Kentaro , SAKAGUCHI, Saito
IPC分类号： A61K31/045 , A61K8/34 , A61P17/00 , A61P25/00 , A61P25/02 , A61P43/00 , A61Q19/00 , C12N5/071 , C12Q1/02 , G01N33/15 , G01N33/483 , G01N33/50
摘要： The purpose of the present invention is to provide skin care focusing on the sense of touch. It was found that sandalore and an analog thereof have an action of activating Merkel cells. Provided is A Merkel cell activating agent containing sandalore and an analog thereof. It was also found that an activated Merkel cell contains a large number of synaptic vesicles. Provided is a synaptic vesicle enhancing agent containing sandalore and an analog thereof. It was also found that the neurotransmitter release activity of Merkel cells can be assessed by measuring, under a fluorescence microscope, changes in fluorescent luminance value before and after depolarization stimulation to Merkel cells that have taken in a fluorescent tracer. Provided is a method for screening for a neurotransmitter release accelerating agent for Merkel cells.
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公开(公告)号：EP2902022B1
公开(公告)日：2020-10-28
申请号：EP13841176.4
申请日：2013-09-27
发明人： NAKAMURA, Mio , KAJIYA, Kentaro , HAZE, Shinichiro
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公开(公告)号：EP4140544A1
公开(公告)日：2023-03-01
申请号：EP21792866.2
申请日：2021-04-19
发明人： HORIBA, Satoshi , HOSOI, Junichi , INOUE, Daigo , KAJIYA, Kentaro , TAKAGI, Masaya , MATSUURA, Yuko , IINO, Masato
IPC分类号： A61Q17/04 , A61Q19/00 , A61Q19/08 , A61H23/02 , A61K8/9761
摘要： The present invention provides an agent for preventing and/or improving photoaging and/or dermal pigmentation comprising Thujae Semen extract as an active ingredient. The present invention also provides a cosmetic method which includes a step for applying the agent for preventing and/or improving photoaging and/or dermal pigmentation to skin to be treated, and a cosmetic device to be applied in said method.
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公开(公告)号：EP2902022A1
公开(公告)日：2015-08-05
申请号：EP13841176.4
申请日：2013-09-27
发明人： NAKAMURA, Mio , KAJIYA, Kentaro , HAZE, Shinichiro
IPC分类号： A61K31/22 , A61K8/37 , A61K8/49 , A61K8/97 , A61K31/351 , A61K36/73 , A61P3/04 , A61P7/10 , A61P17/00 , A61Q19/08
摘要： The purpose of this invention is to find a novel fragrance component effective for prevention or control of swelling, lymphedema, skin aging or obesity from the viewpoint of activation of lymph vessel function by promotion of the expression of VEGFC. This invention provides a swelling improving agent, lymph vessel activator and VEGFC production promoter characterized by containing one or a plurality of components selected from the group consisting of rose oxide, citronellyl acetate and niaouli oil.
摘要翻译： 本发明的目的在于从通过促进VEGFC的表达而激活淋巴管功能的观点，找到对预防或控制肿胀，淋巴水肿，皮肤老化或肥胖有效的新型香味成分。 本发明提供一种肿胀改善剂，淋巴管活化剂和VEGFC生产促进剂，其特征在于含有一种或多种选自玫瑰氧化物，乙酸香茅酯和新油酯的组分。
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5.发明公开METHOD OF EVALUATING CELLULITE AND METHOD OF EVALUATING CELLULITE-EFFECTIVE DRUG USING FIBULIN-3 AND/OR SARCOGLYCAN GAMMA AS AN INDICATOR 有权程序。评估和CELLULITE性评价方法CELLULITISWIRKSTOFFEN使用纤蛋白-3和/或肌聚糖-γ作为指标
公开(公告)号：EP2893345A1
公开(公告)日：2015-07-15
申请号：EP12768911.5
申请日：2012-09-07
申请人： Shiseido Company Ltd. , ETH Zürich
发明人： YOSHIDA, Yuzo , DETMAR, Michael , KAJIYA, Kentaro
IPC分类号： G01N33/50
CPC分类号： G01N33/6881 , C12Q1/6881 , C12Q2600/136 , C12Q2600/158 , G01N33/5044 , G01N2333/4703 , G01N2500/10 , G01N2800/20
摘要： The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.
摘要翻译： 本发明涉及使用纤蛋白-3和/或肌聚糖伽马如在收获皮肤样品中的指示器，以及用于改善，预防或使用治疗脂肪纤蛋白-3和/或肌聚糖的药剂评价的方法评价脂肪团的方法 伽马如在培养的细胞的指标。
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公开(公告)号：EP2319537B1
公开(公告)日：2015-04-29
申请号：EP09766685.3
申请日：2009-06-17
发明人： KAJIYA, Kentaro , OTA, Masahiro
IPC分类号： A61K31/343 , A61K31/34 , A61K36/54 , A61K36/00 , A61P7/10 , A61P17/16 , A61P43/00 , A61K38/18 , A61K38/45
CPC分类号： A61K38/1891 , A61K31/343 , A61K36/254 , A61K36/54 , A61K38/45 , A61K38/00
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公开(公告)号：EP3498823A1
公开(公告)日：2019-06-19
申请号：EP17839584.4
申请日：2017-08-10
摘要： The present invention address the problem of providing a transparent skin sample by removing epidermis via enzymatic treatment.
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8.发明授权METHOD OF EVALUATING CELLULITE AND METHOD OF EVALUATING CELLULITE-EFFECTIVE DRUG USING FIBULIN-3 AND/OR SARCOGLYCAN GAMMA AS AN INDICATOR 有权评估细胞的方法和使用以柔红霉素-3和/或SARCOGLYCAN GAMMA作为指示剂评估纤维素有效药物的方法
公开(公告)号：EP2893345B1
公开(公告)日：2017-11-08
申请号：EP12768911.5
申请日：2012-09-07
申请人： Shiseido Company Ltd. , ETH Zürich
发明人： YOSHIDA, Yuzo , DETMAR, Michael , KAJIYA, Kentaro
IPC分类号： G01N33/50
CPC分类号： G01N33/6881 , C12Q1/6881 , C12Q2600/136 , C12Q2600/158 , G01N33/5044 , G01N2333/4703 , G01N2500/10 , G01N2800/20
摘要： The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.
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公开(公告)号：EP2692352A1
公开(公告)日：2014-02-05
申请号：EP12765928.2
申请日：2012-03-30
发明人： SAWANE, Mika , KAJIYA, Kentaro , TAKAGI, Masaya
IPC分类号： A61K38/00 , A61K45/00 , A61P15/12 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , C07K14/47 , C12N15/09
CPC分类号： C07K14/47 , A61K36/00 , A61K38/00 , A61K38/1709 , A61K39/395 , A61K45/06 , G01N2333/726 , A61K2300/00
摘要： The present invention provides: a hot flash suppressant comprising apelin or an apelin receptor agonist, wherein the apelin receptor agonist is selected from the group consisting of Rubus buergeri, Aster yomena, Stauntonia hexaphylla, Rubus grayana, Kalimeris indica, Lithocarpus edulis, Myrica rubra, Syzgium jambos, Quercus serrata and extracts of these plants, as well as a saffron extract, a pine extract, a cinchona extract, a comfrey extract, a Scutellaria extract, a rosemary extract, an apricot seed powder, a gentian extract, a thyme extract, a mint powder, a jujuba fruit extract, a hop extract, a kiwifruit extract, a roman chamomile extract, an apple extract, a hawthorn extract and a turmeric extract; and a screening method for a medical agent for improving hot flash.
摘要翻译： 本发明提供：包含apelin或apelin受体激动剂的热虹吸抑制剂，其中apelin受体激动剂选自Rubus buergeri，Aster yomena，Stauntonia hexaphylla，悬钩子灰，Kalimeris indica，Lithocarpus edulis，杨梅， 这些植物的提取物以及藏红花提取物，松树提取物，金鸡纳提取物，紫草提取物，黄芩提取物，迷迭香提取物，杏种子粉，龙胆提取物，百里香提取物 ，薄荷粉，枣汁果实提取物，啤酒花提取物，猕猴桃提取物，罗马洋甘菊提取物，苹果提取物，山楂提取物和姜黄提取物; 以及用于改善热闪发的药剂的筛选方法。
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公开(公告)号：EP2319537A1
公开(公告)日：2011-05-11
申请号：EP09766685.3
申请日：2009-06-17
发明人： KAJIYA, Kentaro , OTA, Masahiro
IPC分类号： A61K45/00 , A61K31/11 , A61K31/34 , A61K36/00 , A61K38/22 , A61P7/10 , A61P17/16 , A61P43/00
CPC分类号： A61K38/1891 , A61K31/343 , A61K36/254 , A61K36/54 , A61K38/45 , A61K38/00
摘要： Provided is a lymphatic vessel stabilizer composed of Tie2 activator. The Tie2 activator is preferably at least one type selected from the group consisting of angiopoietin 1 (Ang-1), extract of Cinnamomum species plants, extract of Siberian Ginseng and syringaresinol.
摘要翻译： 提供由Tie2激活剂组成的淋巴管稳定剂。 Tie2激活剂优选为选自血管生成素1（Ang-1），樟属植物提取物，西伯利亚人参提取物和丁香麻醇中的至少一种。
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