摘要:
A convertible plunger is provided comprising an internal portion and a generally cylindrical exterior surface. At least a portion of the exterior surface is maintained in an initial expanded state by a property of the internal portion. The expanded state is reducible to a constricted state by an operation that is applied to the internal portion of the plunger to alter the property. A film coating may also be applied to a sidewall of the sleeve to reduce a sliding friction between the sleeve and barrel. A film coating may also be applied to a nose cone of the plunger to provide a barrier between the plunger and product in the barrel.
摘要:
A method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by setting the ratio of the O2 to the organosilicon precursor in the precursor feed, and/or by setting the electric power used for generating the plasma. In particular, a passivation layer or pH protective coating made by the method is provided. Pharmaceutical packages coated by the method and the use of such packages protecting a composition contained in the vessel against mechanical and/or chemical effects of the surface of the package without a passivation layer or pH protective coating material are also provided.
摘要:
Disclosed is a container comprising a thermoplastic wall defining an inner cavity. The wall supports a SiOx composite barrier coating or layer arranged between the wall and the inner cavity, wherein x is 1.8-2.4. High-resolution X-ray photoelectron spectroscopy (XPS) shows that one interface exists between the composite barrier coating or layer and the wall or a substrate. In one aspect, the interface has O3-Si-C covalent bonds accounting for at least 1 mol% of the proportion of O3-Si-C covalent bonds and SiO4 bonds. In another respect, the interface has chemical shift of Si 2p with the bond energy (eV) lower than the bond energy of SiO4 bonds. The result is a closely attached composite barrier coating or layer having high degree of adhesion with the substrate. The invention also provides a method of applying the composite barrier coating or layer.
摘要:
A three-position plunger is provided including a sleeve having an opening at a distal end, a pre-load cavity proximal to and in communication with the opening, a first cavity proximal to and in communication with the pre-load cavity, a second cavity proximal to and in communication with the pre-load cavity, and at least one rib. The rib(s) is generally aligned with the first cavity. The plunger further includes an insert configured to be displaced from the pre-load cavity to the first cavity and from the first cavity to the second cavity. The insert is configured to provide support for the compression of the rib(s) when the insert is positioned in the first cavity.
摘要:
Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed.
摘要:
A three-position plunger is provided including a sleeve having an opening at a distal end, a pre-load cavity proximal to and in communication with the opening, a first cavity proximal to and in communication with the pre-load cavity, a second cavity proximal to and in communication with the pre-load cavity, and at least one rib. The rib(s) is generally aligned with the first cavity. The plunger further includes an insert configured to be displaced from the pre-load cavity to the first cavity and from the first cavity to the second cavity. The insert is configured to provide support for the compression of the rib(s) when the insert is positioned in the first cavity.
摘要:
A syringe is provided having a barrel and a plunger, the barrel having an inner surface and the plunger having a side surface engaging the barrel inner surface, wherein at least one of the barrel inner surface and the plunger side surface serves as substrate which is coated with a lubricity layer; wherein the lubricity layer comprises a layer of Si w O x C y H z or Si w N x C y H z , where w is 1, x is from about 0.5 to 2.4, y is from about 0.6 to about 3, and z is from 2 to about 9; wherein the surface of the lubricity layer has a lower plunger sliding force or breakout force than the untreated substrate.