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1.发明公开
公开(公告)号：EP2825666A1
公开(公告)日：2015-01-21
申请号：EP13710334.7
申请日：2013-03-08
申请人： Siemens Aktiengesellschaft , Siemens Healthcare Diagnostics Holding GmbH , Siemens Healthcare Diagnostics Inc. , Siemens Healthcare Diagnostics Products GmbH
发明人： KAPPEL, Andreas , KELLER, Andreas , STÄHLER, Cord Friedrich , WRIGHT, Ian , ANDERSON-MAUSER, Linda Marie , BEDZYK, William , SCHWARZ, Herbert , WICKE, Michaela
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , C12Q2537/101 , C12Q2537/1373 , C12Q2545/107 , C12Q2537/125 , C12Q2537/143 , C12Q2563/131
摘要： The invention relates to a method of detecting nucleic acid molecules by immunoassay detection. Detection of a specific nucleic acid molecule of interest is achieved by using a nucleic acid probe in solution which hybridizes in solution to the nucleic acid molecule of interest. Immunoassay detection is achieved by using anantibody specific for the hybrid formed by hybridization of the nucleic acid probe to the nucleic acid molecule of interest.
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公开(公告)号：EP2825666B1
公开(公告)日：2018-12-05
申请号：EP13710334.7
申请日：2013-03-08
申请人： Siemens Healthcare GmbH , Siemens Healthcare Diagnostics Holding GmbH , Siemens Healthcare Diagnostics Inc. , Siemens Healthcare Diagnostics Products GmbH
发明人： KAPPEL, Andreas , KELLER, Andreas , STÄHLER, Cord Friedrich , WRIGHT, Ian , ANDERSON-MAUSER, Linda Marie , BEDZYK, William , SCHWARZ, Herbert , WICKE, Michaela
IPC分类号： C12Q1/6804
CPC分类号： C12Q1/6804 , C12Q2537/101 , C12Q2537/1373 , C12Q2545/107 , C12Q2537/125 , C12Q2537/143 , C12Q2563/131
摘要： The invention relates to a method of detecting nucleic acid molecules by immunoassay detection. Detection of a specific nucleic acid molecule of interest is achieved by using a nucleic acid probe in solution which hybridizes in solution to the nucleic acid molecule of interest. Immunoassay detection is achieved by using anantibody specific for the hybrid formed by hybridization of the nucleic acid probe to the nucleic acid molecule of interest.
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公开(公告)号：EP2847350A1
公开(公告)日：2015-03-18
申请号：EP13734008.9
申请日：2013-06-26
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6804 , C12Q2525/207 , C12Q2537/125 , C12Q2537/159 , C12Q2563/131 , C12Q2563/143
摘要： The invention relates to a method and kit for enriching miRNA nucleic acids molecules of interest in a sampe by selective removal of nucleic acid species, in particular miRNA species, which are not of interest. The invention is based on the surprizing and previously unknown information that only a few individual miRNA species make up the majority of all miRNA species in a sample. Selective removal of these species prior to detection of miRNA nucleic acids molecules will improve assay time, assay sensitivity, and reproducibility.
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