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    METHOD AND COMPACT MARKER FOR MARKING A BIOLOGICAL SAMPLE
    3.
    发明公开
    METHOD AND COMPACT MARKER FOR MARKING A BIOLOGICAL SAMPLE 审中-公开

    公开(公告)号：EP4467658A1

    公开(公告)日：2024-11-27

    申请号：EP23174843.5

    申请日：2023-05-23

    Applicant: Leica Microsystems CMS GmbH ,  PixelBiotech GmbH

    Inventor： Alsheimer, Soeren ,  Cheng, Yongsheng

    IPC: C12Q1/6804 ,  C12Q1/682 ,  C12Q1/6839

    Abstract: A method for marking a biological sample (300) is provided comprising the following steps: providing a biological sample (300) with at least one first target analyte (108); introducing into the biological sample (300) at least one first nucleic acid backbone (102), at least one first label configured to attach to the first nucleic acid backbone (102), and at least one first affinity reagent (106) specific to the first target analyte (108) and configured to attach to the first nucleic acid backbone (102); and introducing into the biological sample (300) a first plurality of staple strands (200), each staple strand (200) configured to hybridise to pairs of folding binding sites of the first nucleic acid backbone (102), in order to fold the first nucleic acid backbone (102) and generate a compact optically detectable first marker (202) in the biological sample (300). In a further aspect a compact marker (202) for marking a biological sample is provided.

    PARTICLE-DROP STRUCTURES AND METHODS FOR MAKING AND USING THE SAME
    4.
    发明公开
    PARTICLE-DROP STRUCTURES AND METHODS FOR MAKING AND USING THE SAME 审中-公开

    公开(公告)号：EP4455301A2

    公开(公告)日：2024-10-30

    申请号：EP24200492.7

    申请日：2018-02-23

    Applicant: The Regents of The University of California

    Inventor： DI CARLO, Dino ,  WU, Chueh-Yu

    IPC: C12Q1/6804

    Abstract: The invention is directed to a particle system comprising a plurality of three-dimensional particles, each particle having an interior region defining a three-dimensional cavity or void and an exterior region, wherein the cavity or void is open to an external environment of the three-dimensional particle and wherein the cavity or void has a volume between about 1 pL and about 125 nL and a molecular capture region disposed on the interior region of the particles configured to capture cells, and to a method of performing an assay using the particle system.

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