公开(公告)号：EP3084437A1

公开(公告)日：2016-10-26

申请号：EP14872376.0

申请日：2014-12-17

申请人： Siemens Healthcare Diagnostics Inc.

发明人： PUGIA, Michael ,  MARFURT, Karen L.

IPC分类号： G01N33/53 ,  G01N33/567

CPC分类号： G01N33/86 ,  G01N33/5091 ,  G01N2333/96463 ,  G01N2800/224 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： Methods are disclosed for determining a level of endothelial disease in a subject. The methods comprise examining circulating endothelial cells from the subject for the presence of one or more coagulation factors and correlating an amount of circulating endothelial cells exhibiting one or more coagulation factors with the level of endothelial disease in the subject. Anti-coagulation factor therapy can then be administered to the subject to address the endothelial disease.

摘要翻译： 公开了测定受试者中内皮疾病水平的方法。 该方法包括检查来自受试者的循环内皮细胞中是否存在一种或多种凝血因子，并将呈现一种或多种凝血因子的循环内皮细胞的量与受试者中内皮疾病的水平相关联。 然后可以对受试者施用抗凝因子治疗以解决内皮疾病。

公开(公告)号：EP3084437B1

公开(公告)日：2018-02-28

申请号：EP14872376.0

申请日：2014-12-17

申请人： Siemens Healthcare Diagnostics Inc.

发明人： PUGIA, Michael ,  MARFURT, Karen L.

IPC分类号： G01N33/53 ,  G01N33/567

CPC分类号： G01N33/86 ,  G01N33/5091 ,  G01N2333/96463 ,  G01N2800/224 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： Methods are disclosed for determining a level of endothelial disease in a subject. The methods comprise examining circulating endothelial cells from the subject for the presence of one or more coagulation factors and correlating an amount of circulating endothelial cells exhibiting one or more coagulation factors with the level of endothelial disease in the subject. Anti-coagulation factor therapy can then be administered to the subject to address the endothelial disease.

公开(公告)号：EP3027226A2

公开(公告)日：2016-06-08

申请号：EP14832562.4

申请日：2014-07-30

申请人： Siemens Healthcare Diagnostics Inc.

发明人： PUGIA, Michael ,  MARFURT, Karen L.

IPC分类号： A61K48/00 ,  C12N5/00 ,  C12N15/867

CPC分类号： G01N33/5023 ,  C12N5/0602 ,  G01N33/5005 ,  G01N33/5044 ,  G01N33/5064 ,  G01N33/574 ,  G01N33/96 ,  G01N2001/2893

摘要： Control cells include a stable intact cell and, on the surface of the stable intact cell, a plurality of different antigens. Each of the different antigens corresponds to an antigen of interest. The control cells are employed in methods of evaluating the efficacy of a biological procedure performed on a sample. The method comprises conducting the biological procedure in the presence of the control cells. The control cells are examined to determine the efficacy of the biological procedure.