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    RED BLOOD CELL DYNAMICS FOR DIAGNOSIS
    2.
    发明公开
    RED BLOOD CELL DYNAMICS FOR DIAGNOSIS 审中-公开
    红血球细胞动力学诊断

    公开(公告)号：EP3246709A2

    公开(公告)日：2017-11-22

    申请号：EP17160801.1

    申请日：2011-09-16

    申请人： The General Hospital Corporation

    发明人： HIGGINS, John M.

    IPC分类号： G01N33/72 ,  G01N33/555 ,  G01N33/49 ,  G01N33/68

    CPC分类号： C12Q1/02 ,  G01N33/6893 ,  G01N33/721 ,  G01N33/80 ,  G01N33/94 ,  G01N2800/06 ,  G01N2800/22 ,  G01N2800/224

    摘要： Methods for identifying patients with anemia, distinguishing thalassemia-trait anemia from iron-deficiency anemia, and identifying pre-anemic patients several weeks before anemia becomes clinically detectable. Also, methods for detecting blood doping in athletes and for optimizing therapy with erythropoiesis stimulating agents or iron supplementation. Computer-readable storage devices and systems, e.g., for use in the described methods.

    摘要翻译： 鉴别贫血患者，区分贫血性贫血和缺铁性贫血的方法，以及贫血症发病几周前鉴别贫血前患者的方法在临床上可以被检测到。 此外，还提供了检测运动员血液兴奋剂和优化红细胞生成刺激剂或补铁治疗的方法。 计算机可读存储设备和系统，例如用于所描述的方法中。

    METHODE DE DETERMINATION DU PROFIL DE STRUCTURE D'UN CAILLOT DE FIBRINE REFLETANT SA STABILITE, POUR PREDIRE LE RISQUE DE SAIGNEMENT, DE THROMBOSE OU DE RE-THROMBOSE
    3.
    发明公开
    METHODE DE DETERMINATION DU PROFIL DE STRUCTURE D'UN CAILLOT DE FIBRINE REFLETANT SA STABILITE, POUR PREDIRE LE RISQUE DE SAIGNEMENT, DE THROMBOSE OU DE RE-THROMBOSE 审中-公开
    程序用于确定结构体轮廓的纤维蛋白凝块作为预测出血风险的IT稳定性的一种表达，血小板血栓形成或血栓重新的

    公开(公告)号：EP3177921A1

    公开(公告)日：2017-06-14

    申请号：EP15754272.1

    申请日：2015-07-24

    申请人： Diagnostica Stago ,  Centre National de la Recherche Scientifique (C.N.R.S.) ,  Université Grenoble Alpes ,  Centre Hospitalier Universitaire Grenoble

    发明人： CONTANT, Geneviève ,  POLACK, Benoît ,  CATON, François ,  DASSI, Carhel

    IPC分类号： G01N33/49

    CPC分类号： G01N33/4905 ,  G01N21/31 ,  G01N2201/12 ,  G01N2333/7454 ,  G01N2333/75 ,  G01N2800/224 ,  G01N2800/226 ,  G01N2800/50

    摘要： The present invention relates to a method for dynamically determining the structural profile of a fibrin clot, reflecting the stability thereof in a biological sample of a patient, said method comprising the following steps: a) mixing the undiluted biological sample with tissue factor or a mixture of tissue factor and tissue plasminogen activator; b) incubating the mixture obtained in step a), then adding calcium ions to the mixture obtained, in order to initiate the formation of a fibrin clot; c) measuring the turbidity or the optical density of the clot being formed in step b), at at least two wavelengths of between 450 nm and 850 nm, and for a time of between 1 and 35 minutes; d) determining the structural profile of the analysed clot, expressed as a number of protofibrils, density and radius in c) by means of the formula τ.λ
    5 = A [Fg].(λ
    2 - B), wherein τ is the turbidity of the clot at a given wavelength λ, [Fg] is the initial weight concentration of fibrinogen, and A and B are coefficients which are proportional, respectively, to the density and the radius of the fibres that make up the clot; and e) comparing the obtained profile with a control. The method preferably includes a step f) that makes it possible to predict the risk of bleeding, thrombosis or rethrombosis and to select the anticoagulant that is best suited to the clinical situation of a patient.

    摘要翻译： 本发明涉及一种用于动态地确定的采矿纤维蛋白凝块的结构轮廓，反映其稳定性的患者的生物样品中，所述方法包括以下步骤：a）将与组织因子或它们的混合物的未稀释的生物样品 的组织因子和组织纤维蛋白溶酶原激活剂; b）孵育步骤a中得到的混合物），然后加入钙离子在为了启动纤维蛋白凝块的形成中得到的混合物; c）测量浊度或凝块的光密度形成在步骤b）中，在至少两个450纳米和850纳米，以及之间的1分钟和35之间时的波长; D）确定性采矿由式τ.λ5手段所分析的凝块的结构轮廓，表示为多个原细纤维，在C的密度和半径）= A [蛋白原]（λ2 - B），worinτ是的浊度 在给定的波长λ的凝块，[蛋白原]是初始重量浓度的纤维蛋白原的，并且A和B是系数，分别哪些是成比例的，以密度和纤维也构成了凝块的半径; 和e）比较与对照获得的轮廓。 该方法优选地包括步骤f）那样，能够预测出血，血栓形成或血栓重新的风险，并以选择抗凝血剂所做的是最适合于患者的临床情况。

    BLOOD SAMPLE ANALYZING METHOD AND BLOOD SAMPLE ANALYZER
    4.
    发明公开
    BLOOD SAMPLE ANALYZING METHOD AND BLOOD SAMPLE ANALYZER 审中-公开
    BLUTPROBENANALYSEVERFAHREN UND BLUTPROBENANALYSATOR

    公开(公告)号：EP3136104A1

    公开(公告)日：2017-03-01

    申请号：EP16183343.9

    申请日：2016-08-09

    申请人： SYSMEX CORPORATION

    发明人： Hayasaki, Junki

    IPC分类号： G01N33/86 ,  G01N21/75

    CPC分类号： G01N33/86 ,  G01N21/272 ,  G01N21/82 ,  G01N2333/075 ,  G01N2333/75 ,  G01N2800/224

    摘要： Disclosed is a blood sample analyzing method including preparing a measurement specimen by mixing a blood sample with a measuring reagent of fibrin and a fibrinogen degradation product (FDP); acquiring, based on a time-dependent change in optical information obtained by optically measuring the measurement specimen, first information indicating an FDP concentration and second information indicating a curving degree of a time course curve showing the time-dependent change of the optical information; and determining an enhanced fibrinolytic state of the blood sample or acquiring a value related to a D dimer of the blood sample based on the first information and the second information.

    摘要翻译： 公开了一种血液样品分析方法，其包括通过将血液样品与纤维蛋白的测定试剂和纤维蛋白原降解产物（FDP）混合来制备测定试样; 基于通过光学测量所述测量样本获得的光学信息的时间依赖性变化获取指示FDP浓度的第一信息和指示表示所述光学信息的时间变化的时间过程曲线的弯曲程度的第二信息; 以及基于所述第一信息和所述第二信息确定所述血液样品的增强的纤维蛋白溶解状态或获取与所述血液样品的D二聚体相关的值。

    AUTOMATIC ANALYZER
    5.
    发明公开
    AUTOMATIC ANALYZER 审中-公开
    自动化分析仪

    公开(公告)号：EP3076183A1

    公开(公告)日：2016-10-05

    申请号：EP14865780.2

    申请日：2014-10-22

    申请人： Hitachi High-Technologies Corporation

    发明人： SHIMAMORI Toshiyuki ,  MAKINO Akihisa ,  ISHIZAWA Masato

    IPC分类号： G01N35/10 ,  G01N33/86 ,  G01N35/02

    CPC分类号： G01N33/86 ,  G01N21/11 ,  G01N33/491 ,  G01N35/1002 ,  G01N35/1011 ,  G01N35/1016 ,  G01N35/1083 ,  G01N2021/825 ,  G01N2035/00346 ,  G01N2035/0453 ,  G01N2035/1058 ,  G01N2800/224

    摘要： If an air bubble is entrained when a reagent is added to a sample, disturbance caused by this air bubble may prevent accurate optical measurement, thereby reducing accuracy for measuring blood clotting ability. The position to dispense the reagent depends on accuracy of stopping a reagent dispensing mechanism and dimensional errors of individual detectors, and thus conventional reagent discharging method may entrain an air bubble because a distance between a nozzle for dispensing the reagent and an inner wall of a reaction vessel is not constant and conditions for dispensing the reagent to the sample vary each time. In the present invention, an automatic analyzer with a nozzle for sucking and discharging the reagent for blood clotting reaction is provided with a dispensing mechanism that keeps a constant position for the nozzle to discharge the reagent by pressing the nozzle against the inner wall of the reaction vessel within the elastic range.

    摘要翻译： 如果将试剂添加到样品中时气泡被夹带，则由该气泡引起的干扰可能妨碍精确的光学测量，从而降低测量血液凝固能力的准确性。 分配试剂的位置取决于停止试剂分配机构的精度和各个检测器的尺寸误差，因此常规的试剂排放方法可能夹带气泡，因为用于分配试剂的喷嘴和反应的内壁之间的距离 容器不是恒定的，并且用于将试剂分配到样品的条件每次都变化。 在本发明中，具有用于吸引和排出用于凝血反应的试剂的喷嘴的自动分析器设置有分配机构，其通过将喷嘴压靠在反应的内壁上而使喷嘴保持恒定的位置来排出试剂 容器在弹性范围内。