公开(公告)号：EP1838710A1

公开(公告)日：2007-10-03

申请号：EP06718361.6

申请日：2006-01-13

申请人： SIGNAL PHARMACEUTICALS, INC. ,  Pharmacopeia Drug Discovery, Inc.

发明人： ALBERS, Ronald ,  AYALA, Leticia ,  CLAREEN, Steven, S. ,  DELGADO MEDEROS, Maria, M. ,  HILGRAF, Robert ,  HEDGE, Sayee ,  HUGHES, Kevin ,  KOIS, Adam ,  PLANTEVIN-KRENITSKY, Veronique ,  MCCARRICK, Meg ,  NADOLNY, Lisa ,  PALANKI, Moorthy ,  SAHASRABUDHE, Kiran ,  SAPIENZA, John ,  SATOH, Yoshitaka ,  SLOSS, Marian ,  SUDBECK, Elise ,  WRIGHT, Jonathan

IPC分类号： C07D473/00 ,  C07D473/32 ,  A61K31/52 ,  A61P3/00 ,  A61P9/00

CPC分类号： C07D473/00 ,  A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: (I) wherein R1 , R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

公开(公告)号：EP1556374A2

公开(公告)日：2005-07-27

申请号：EP03777639.0

申请日：2003-10-15

申请人： Signal Pharmaceuticals, Inc.

发明人： FRIEDMAN, Glenn ,  MCKIE, Jeffrey ,  WRIGHT, Jonathan

IPC分类号： C07D405/02 ,  A61K31/40

CPC分类号： C07D311/16 ,  A61K31/40

摘要： This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or neoplastic cell comprising administering an effective amount of a Benzopyranone Compound. The Benzopyranone Compounds have the formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is halogen, trifluoromethyl or C1-6 alkyl.