公开(公告)号：EP4382518A2

公开(公告)日：2024-06-12

申请号：EP24155841.0

申请日：2017-08-23

申请人： Iowa State University Research Foundation, Inc.

发明人： Coats, Joel R. ,  Klimavicz, James Scott ,  Norris, Edmund J.

IPC分类号： C07D333/24

CPC分类号： A01N37/06 ,  A01N37/08 ,  A01N37/10 ,  A01N43/16 ,  A01N43/30 ,  A01N49/00 ,  C07D311/16 ,  C07C69/24 ,  C07C69/74 ,  C07D333/24 ,  C07D333/38 ,  C07D305/06 ,  C07D305/08 ,  C07D307/68 ,  C07C69/07 ,  C07C69/533 ,  C07C69/587 ,  C07C69/618 ,  C07C69/63 ,  C07C255/19 ,  C07C2602/4220170501 ,  C07C2601/0220170501 ,  C07C2601/0420170501 ,  C07C2601/1420170501 ,  C07C69/635 ,  C07C69/75 ,  C07C69/757 ,  C07C69/76 ,  C07D333/40

摘要： The present invention relates to monoterpenoid and phenylpropanoid containing derivative compounds, methods of making the compounds, compositions comprising the compounds, and methods of repelling pests using the compounds and/or compositions.

公开(公告)号：EP4367111A1

公开(公告)日：2024-05-15

申请号：EP22837041.7

申请日：2022-07-08

申请人： Sironax Ltd.

发明人： ZHANG, Zhiyuan ,  HOU, Weijie ,  JIANG, Yimin ,  XU, Yanping ,  HAN, Jianguang

IPC分类号： C07D401/12 ,  C07C211/55 ,  A61K31/136 ,  A61K31/395

CPC分类号： C07D401/12 ,  C07D413/12 ,  C07D265/36 ,  C07D498/08 ,  C07D217/04 ,  C07D217/06 ,  C07D311/16 ,  C07D311/14 ,  C07D405/12 ,  C07D209/44 ,  C07D209/46 ,  C07D413/14 ,  C07D471/04 ,  A61P25/28

公开(公告)号：EP2555768B1

公开(公告)日：2018-08-29

申请号：EP11715346.0

申请日：2011-04-05

申请人： Fosun Orinove Pharmatech, Inc.

发明人： ZENG, Qingping ,  TORO, Andras ,  PATTERSON, John, Bruce ,  WADE, Warren, Stanfield ,  ZUBOVICS, Zoltan ,  YANG, Yun ,  WU, Zhipeng

IPC分类号： C07D311/20 ,  C07D311/94 ,  C07D401/04 ,  C07D405/04 ,  C07D405/10 ,  A61K31/37 ,  C07D409/04 ,  C07D417/04 ,  C07D311/12 ,  C07D311/16 ,  C07D217/02 ,  C07D217/08 ,  C07D311/22 ,  C07D401/12 ,  A61P35/00 ,  A61P31/12 ,  A61P43/00

CPC分类号： A61K31/366 ,  A61K31/343 ,  A61K31/352 ,  A61K31/37 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4172 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/452 ,  A61K31/453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D217/02 ,  C07D217/08 ,  C07D311/12 ,  C07D311/16 ,  C07D311/20 ,  C07D311/22 ,  C07D311/94 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D405/10 ,  C07D409/04 ,  C07D417/04 ,  Y02A50/389 ,  Y02A50/393

摘要： Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.

公开(公告)号：EP3363793A1

公开(公告)日：2018-08-22

申请号：EP17156321.6

申请日：2017-02-15

申请人： Merck Patent GmbH

发明人： The designation of the inventor has not yet been filed

IPC分类号： C07D311/16 ,  C07D335/06 ,  C08F124/00 ,  C08F128/06 ,  A61F2/16

CPC分类号： C07D311/16 ,  C07D335/06 ,  C08F124/00 ,  C08F128/06

摘要： The invention relates to novel polymerizable compounds of formula (I), especially to compounds comprising a photoactive unit, said compounds being suitable for ophthalmic devices, in particular for intraocular lenses. The invention also relates to compositions, polymers and ophthalmic devices comprising such compounds.

公开(公告)号：EP3272744A4

公开(公告)日：2018-07-25

申请号：EP15885452

申请日：2015-03-18

申请人： ADEKA CORP

发明人： YANAGISAWA SATOSHI ,  TODA HITOMI ,  SHIGENO KOICHI ,  KIMURA MASAKI

IPC分类号： C07D311/16 ,  C08G59/68 ,  G03F7/004

CPC分类号： C07D311/16 ,  C07C309/06 ,  C07C309/30 ,  C08G59/68 ,  C08G59/687 ,  G03F7/004 ,  G03F7/0045

摘要： Provided are: an aromatic sulfonium salt compound which exhibits low corrosion to a substrate and excellent photolithographic characteristics and is thus useful as a photoacid generator and as a cationic polymerization agent; and a photoacid generator, a resist composition, a cationic polymerization initiator and a cationically polymerizable agent composition, which include the aromatic sulfonium salt compound. The aromatic sulfonium salt compound is represented by the following Formula (I): (wherein, R 1 to R 10 each independently represent a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an alkyl group having 1 to 18 carbon atoms which is optionally substituted, or the like; R 11 to R 15 each independently represent a hydrogen atom, an alkoxy group having 1 to 18 carbon atoms which is optionally substituted, or the like; at least one of R 11 to R 15 is not a hydrogen atom; and X 1 - represents a monovalent organic sulfonate anion).

公开(公告)号：EP3337794A1

公开(公告)日：2018-06-27

申请号：EP16750618.7

申请日：2016-08-03

申请人： Merck Patent GmbH

发明人： DOBELMANN-MARA, Lars ,  RIEDMUELLER, Stefan ,  SCHRAUB, Martin

IPC分类号： C07D311/42 ,  C07D215/227

CPC分类号： C07D311/16 ,  A61L27/50 ,  A61L2430/16 ,  C07D215/227 ,  C07D311/42 ,  C07D335/06

摘要： The present invention relates to novel compounds, particularly to hydrophilic compounds, comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices. The present application also relates to ophthalmic devices comprising such compounds.

公开(公告)号：EP3337792A1

公开(公告)日：2018-06-27

申请号：EP16750616.1

申请日：2016-08-03

申请人： Merck Patent GmbH

发明人： DOBELMANN-MARA, Lars ,  RIEDMUELLER, Stefan ,  SCHRAUB, Martin

IPC分类号： C07D311/16 ,  C07D335/06 ,  A61F2/16

CPC分类号： C07D311/16 ,  A61L27/16 ,  A61L27/50 ,  C07D335/06 ,  C08F20/30 ,  C08F20/38 ,  C08F20/40 ,  G02B1/041

摘要： The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices as well as to ophthalmic devices comprising such compounds.

公开(公告)号：EP2857392B1

公开(公告)日：2018-06-13

申请号：EP13784486.6

申请日：2013-04-30

申请人： Japanese Foundation For Cancer Research

发明人： YAO, Ryoji ,  OSADA, Hiroyuki ,  KONDOH, Yasumitsu

IPC分类号： C07D311/16 ,  A61K31/37 ,  A61K31/4025 ,  A61K31/4433 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/55 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07D401/14

CPC分类号： C07D405/14 ,  A61K31/37 ,  A61K31/4025 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/5377 ,  C07D311/16 ,  C07D401/14 ,  C07D403/14 ,  C07D407/04

摘要： The present invention provides a small compound targeting at TACC3. The present invention further provides a drug, particularly, an anticancer agent, comprising the small compound targeting at TACC3. A compound represented by the general formula (I) or a pharmaceutically acceptable salt, solvate, or ester derivative thereof binds to TACC3 and inhibits cell growth. Thus, these compounds can be used as drugs, particularly, anticancer agents.

公开(公告)号：EP2295053B8

公开(公告)日：2018-03-28

申请号：EP10190730.1

申请日：2003-12-05

申请人： Institute of Materia Medica, Chinese Academy of Medical Sciences

发明人： Xu, Shiping ,  Chen, Xiaoguang ,  Xu, Song ,  Li, Lanmin ,  Xie, Longfei ,  Li, Hongyan ,  Li, Yan ,  Cheng, Guifang

IPC分类号： C07D413/14 ,  C07D311/16 ,  C07D405/12 ,  C07D413/04 ,  C07D417/12

CPC分类号： C07D413/04 ,  C07D311/16 ,  C07D405/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas.

公开(公告)号：EP3272744A1

公开(公告)日：2018-01-24

申请号：EP15885452.1

申请日：2015-03-18

申请人： Adeka Corporation

发明人： YANAGISAWA, Satoshi ,  TODA, Hitomi ,  SHIGENO, Koichi ,  KIMURA, Masaki

IPC分类号： C07D311/16 ,  C08G59/68 ,  G03F7/004

CPC分类号： C07D311/16 ,  C07C309/06 ,  C07C309/30 ,  C08G59/68 ,  C08G59/687 ,  G03F7/004 ,  G03F7/0045

摘要： Provided are: an aromatic sulfonium salt compound which exhibits low corrosion to a substrate and excellent photolithographic characteristics and is thus useful as a photoacid generator and as a cationic polymerization agent; and a photoacid generator, a resist composition, a cationic polymerization initiator and a cationically polymerizable agent composition, which include the aromatic sulfonium salt compound. The aromatic sulfonium salt compound is represented by the following Formula (I):

(wherein, R 1 to R 10 each independently represent a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an alkyl group having 1 to 18 carbon atoms which is optionally substituted, or the like; R 11 to R 15 each independently represent a hydrogen atom, an alkoxy group having 1 to 18 carbon atoms which is optionally substituted, or the like; at least one of R 11 to R 15 is not a hydrogen atom; and X 1 - represents a monovalent organic sulfonate anion).

摘要翻译： 本发明提供一种芳香族锍盐化合物，其对基材显示出低的腐蚀性和优异的光刻特性，因此可用作光酸产生剂和阳离子聚合剂; 以及包含芳香族锍盐化合物的光酸产生剂，抗蚀剂组合物，阳离子聚合引发剂和阳离子聚合剂组合物。 所述芳族锍盐化合物由下式（I）表示：其中，R 1至R 10各自独立地表示氢原子，卤素原子，羟基，硝基，氰基，具有1至10个碳原子的烷基 任选被取代的18个碳原子等; R 11至R 15各自独立地表示氢原子，任选被取代的具有1至18个碳原子的烷氧基等; R 11至R 15中的至少一个不是 氢原子;并且X1-表示一价有机磺酸根阴离子）。