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1.发明公开SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 审中-公开取代DIAMINOCARBOXAMID-和DIAMINOCARBONITRILPYRIMIDINE，THEREOF组合物和治疗方法，这些方法
公开(公告)号：EP2699553A1
公开(公告)日：2014-02-26
申请号：EP12718524.7
申请日：2012-04-20
发明人： BENNETT, Brydon, L. , ELSNER, Jan , ERDMAN, Paul , HILGRAF, Robert , LEBRUN, Laurie, Ann , MCCARRICK, Meg , MOGHADDAM, Mehran, F. , NAGY, Mark, A. , NORRIS, Stephen , PAISNER, David, A. , SLOSS, Marianne , ROMANOW, William, J. , SATOH, Yoshitaka , TIKHE, Jayashree , YOON, Won, Hyung , DELGADO, Mercedes
IPC分类号： C07D239/48 , C07D405/02 , C07D401/12 , C07D409/12
CPC分类号： C07D239/48 , A61K31/505 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Provided herein are Diaminopyrimidine Compounds having the following structures: wherein R
1 , R
2 , R
3, and R
4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.-
公开(公告)号：EP2344494B1
公开(公告)日：2016-04-20
申请号：EP09789271.5
申请日：2009-09-08
发明人： BAHMANYAR, Sogole , BATES, R.J. , BLEASE, Kate , CALABRESE, Andrew, Antony , DANIEL, Thomas, Oran , DELGADO, Mercedes , ELSNER, Jan , ERDMAN, Paul , FAHR, Bruce , FERGUSON, Gregory , LEE, Branden , NADOLNY, Lisa , PACKARD, Garrick , PAPA, Patrick , PLANTEVIN-KRENITSKY, Veronique , RIGGS, Jennifer , ROHANE, Patricia , SANKAR, Sabita , SAPIENZA, John , SATOH, Yoshitaka , SLOAN, Victor , STEVENS, Randall , TEHRANI, Lida , TIKHE, Jayashree , TORRES, Eduardo , WALLACE, Andrew , WHITEFIELD, Brandon, Wade , ZHAO, Jingjing
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P5/00 , A61P25/00 , A61P9/00 , A61P19/00 , A61P29/00
CPC分类号： C07D471/04 , C07D519/00
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公开(公告)号：EP2344494A1
公开(公告)日：2011-07-20
申请号：EP09789271.5
申请日：2009-09-08
发明人： BAHMANYAR, Sogole , BATES, R.J. , BLEASE, Kate , CALABRESE, Andrew, Antony , DANIEL, Thomas, Oran , DELGADO, Mercedes , ELSNER, Jan , ERDMAN, Paul , FAHR, Bruce , FERGUSON, Gregory , LEE, Branden , NADOLNY, Lisa , PACKARD, Garrick , PAPA, Patrick , PLANTEVIN-KRENITSKY, Veronique , RIGGS, Jennifer , ROHANE, Patricia , SANKAR, Sabita , SAPIENZA, John , SATOH, Yoshitaka , SLOAN, Victor , STEVENS, Randall , TEHRANI, Lida , TIKHE, Jayashree , TORRES, Eduardo , WALLACE, Andrew , WHITEFIELD, Brandon, Wade , ZHAO, Jingjing
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P5/00 , A61P25/00 , A61P9/00 , A61P19/00 , A61P29/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided herein are Heteroaryl Compounds of formula (I): wherein R
1 and R
2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.
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