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公开(公告)号：EP2010561A1
公开(公告)日：2009-01-07
申请号：EP07748666.0
申请日：2007-04-27
发明人： BEUERMAN, Roger , ZHOU, Lei , LIU, Shouping , LI, Jing , SURESH, Anita , VERMA, Chandra Shekhar , TAN, Donald
CPC分类号： A61K38/1729 , A61K38/00 , C07K14/4723 , Y02A50/473
摘要： There is provided at least one isolated antimicrobial peptide, wherein the peptide is a linear analog of hBD3 or a fragment thereof. In particular, there is provided a linear analog of hBD3 wherein the peptide has a reduced cytotoxicity to at least one cell compared to the wild type hBD3.
摘要翻译： 提供了至少一种分离的抗微生物肽，其中所述肽是hBD3或其片段的线性类似物。 具体而言，提供了hBD3的线性类似物，其中所述肽与野生型hBD3相比对至少一种细胞具有降低的细胞毒性。
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公开(公告)号：EP3969448A1
公开(公告)日：2022-03-23
申请号：EP20809100.9
申请日：2020-05-18
申请人： Singapore Health Services Pte. Ltd. , Agency for Science, Technology and Research , Tan Tock Seng Hospital Pte Ltd
发明人： AUNG, Thet Tun , LI, Jianguo , KOH, Jun Jie , RAJAMANI, Lakshminarayanan , BEUERMAN, Roger , TAN, Tiang Hwee Donald , PERIAYAH, Mercy Halleluyah , VERMA, Chandra Shekhar , CHEN, Swaine , BARKHAM, Timothy
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4433 , A61K31/444 , A61P31/04
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公开(公告)号：EP4444740A2
公开(公告)日：2024-10-16
申请号：EP22904949.9
申请日：2022-12-05
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公开(公告)号：EP2904000A1
公开(公告)日：2015-08-12
申请号：EP13844064.9
申请日：2013-10-01
发明人： JOSEPH, Thomas Leonard , VERMA, Chandra Shekhar , LANE, David Phillip , BROWN, Christopher John
摘要： By using a phage display derived peptide as an initial template, compounds have been developed that are highly specific against Mdm2/Mdm4. These compounds exhibit greater potency in p53 activation and protein-protein interaction assays than a compound derived from the p53 wild-type sequence. Unlike nutlin, a small molecule inhibitor of Mdm2/Mdm4, the phage derived compounds can arrest cells resistant to p53 induced apoptosis over a wide concentration range without cellular toxicity, suggesting they are highly suitable for cyclotherapy.
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5.发明公开
公开(公告)号：EP2912463A1
公开(公告)日：2015-09-02
申请号：EP13849032.1
申请日：2013-10-25
发明人： GHADESSY, Farid , VERMA, Chandra Shekhar , LANE, David Philip , SIAU, Jia Wei , JOSEPH, Thomas Leonard , SIM, Adelene Yen Ling
IPC分类号： G01N33/53 , C12Q1/68 , C07K14/435 , C12N9/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/5011 , G01N2333/4748 , G01N2333/9015
摘要： The present disclosure provides a method of determining resistance of a biological molecule to inhibition of its interaction with a target molecule by an inhibitor of the biological molecule, the method comprising the steps of: a) co-compartmentalizing a gene encoding the biological molecule with the target molecule, or a gene encoding the biological molecule with a gene encoding the target molecule into an aqueous droplet disposed within a water-in-oil emulsion, and b) assaying for a complex comprising the biological molecule and the target molecule upon expression of the gene encoding the biological molecule and the gene encoding the target molecule, wherein detection of the complex in the presence of the inhibitor indicates that the biological molecule is resistant to inhibition of its interaction with the target molecule by the inhibitor. Also provided are mutated HDM2 ubiquitin ligase polypeptides exhibiting resistance to Nutlin inhibition of p53 binding.
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6.发明公开
公开(公告)号：EP4441067A1
公开(公告)日：2024-10-09
申请号：EP22899364.8
申请日：2022-11-23
发明人： JOSIEN, Hubert , CHANDRAMOHAN, Arun , JOHANNES, Charles, William , BROWN, Christopher, J. , KANNAN, Srinivasaraghavan , PARTRIDGE, Anthony, W. , VERMA, Chandra Shekhar , YAN, Lin , YUEN, Tsz Ying
CPC分类号： A61K38/03 , A61P35/00 , C07K7/08 , C07K14/001 , A61K38/00
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公开(公告)号：EP2976354A1
公开(公告)日：2016-01-27
申请号：EP14768664.6
申请日：2014-02-28
发明人： BROWN, Christopher John , LANE, David Philip , QUAH, Soo Tng , LAMA, Dilraj , VERMA, Chandra Shekhar
CPC分类号： C07K7/08 , A61K38/00 , C07K14/4705
摘要： The present invention relates to cross-linked peptides that are associated with human eIF4G and bind to eIF4E, uses thereof and pharmaceutical compositions comprising the peptides.
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