公开(公告)号：EP2725013A1

公开(公告)日：2014-04-30

申请号：EP12804621.6

申请日：2012-06-26

申请人： Sinopharm A-Think Pharmaceutical Co., Ltd ,  Shanghai Institute Of Pharmaceutical Industry

发明人： LI, Jianqi ,  ZHANG, Qingwei ,  JIA, Zhidan ,  WANG, Jiajing

IPC分类号： C07D209/04 ,  C07D213/02 ,  C07D235/02 ,  C07D271/12 ,  C07D283/00 ,  C07D307/77 ,  C07D327/02 ,  C07D333/52 ,  C07C233/88 ,  A61K31/44 ,  A61K31/444 ,  A61K31/166 ,  A61P5/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00

CPC分类号： C07C237/48 ,  C07C237/42 ,  C07D209/42 ,  C07D213/75 ,  C07D235/24 ,  C07D307/85 ,  C07D307/87 ,  C07D307/88 ,  C07D333/70 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

摘要： Disclosed in the present invention is a novel histone deacetylase inhibitor of benzamides and use thereof. The inhibitor has good efficacy in treating diseases caused by abnormal gene expression, such as tumours, endocrine disorders, immune system diseases, genetic diseases and nerve system diseases. The histone deacetylase inhibitor of benzamides is a compound of the following general chemical structural formula (I) or a salt thereof.

摘要翻译： 本发明公开了苯甲酰胺的新型组蛋白脱乙酰酶抑制剂及其用途。 该抑制剂对肿瘤，内分泌失调，免疫系统疾病，遗传病，神经系统疾病等异常基因表达引起的疾病具有良好的治疗效果。 苯甲酰胺的组蛋白脱乙酰酶抑制剂是以下通式化学结构式（I）的化合物或其盐。

公开(公告)号：EP2725013B1

公开(公告)日：2018-08-22

申请号：EP12804621.6

申请日：2012-06-26

申请人： Sinopharm A-Think Pharmaceutical Co., Ltd ,  Shanghai Institute Of Pharmaceutical Industry

发明人： LI, Jianqi ,  ZHANG, Qingwei ,  JIA, Zhidan ,  WANG, Jiajing

IPC分类号： C07D209/04 ,  C07D213/02 ,  C07D235/02 ,  C07D271/12 ,  C07D283/00 ,  C07D307/77 ,  C07D327/02 ,  C07D333/52 ,  C07C233/88 ,  A61K31/44 ,  A61K31/444 ,  A61K31/166 ,  A61P5/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00

CPC分类号： C07C237/48 ,  C07C237/42 ,  C07D209/42 ,  C07D213/75 ,  C07D235/24 ,  C07D307/85 ,  C07D307/87 ,  C07D307/88 ,  C07D333/70 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

摘要： Disclosed in the present invention is a novel histone deacetylase inhibitor of benzamides and use thereof. The inhibitor has good efficacy in treating diseases caused by abnormal gene expression, such as tumours, endocrine disorders, immune system diseases, genetic diseases and nerve system diseases. The histone deacetylase inhibitor of benzamides is a compound of the following general chemical structural formula (I) or a salt thereof.