摘要:
Disclosed in the present invention is a novel histone deacetylase inhibitor of benzamides and use thereof. The inhibitor has good efficacy in treating diseases caused by abnormal gene expression, such as tumours, endocrine disorders, immune system diseases, genetic diseases and nerve system diseases. The histone deacetylase inhibitor of benzamides is a compound of the following general chemical structural formula (I) or a salt thereof.
摘要:
Compounds of formula (1), wherein: R?1 and R2¿ are independently selected from the group comprising hydrogen, C¿1? to C6 alkyl, C1 to C6 haloalkyl, phenyl, and substituted phenyl; X is selected from the group comprising sulfur, sulphone, disulfide; Y is selected from oxygen, carbon, N-H, N-alkyl, N-aryl, or sulfur; and Z is any linking functionality. The compounds represent a new class of ring opening monomers.
摘要:
There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositiors containing such benzo-fused lactams as the active ingredient thereof are also disclosed.
摘要:
The use of a compound of formula (I) wherein X is (i), (ii) or (iii), formula (i),formula (ii), formula (iii) Y is O, S(O)m, NR3, CR5R6, CR5R6-CR7R8, O-CR7R8, S(O)m-CR7R8, NR3-CR7R8, CR5R6 -O, CR5R6-S(O)m, CR5R6-NR3, SO2-NR3, NR3-SO2, NR3-O or O-NR3; m is 0, 1, or 2; the ring (T) formula (T) is a 5- or 6-membered aromatic or heteroaromatic ring; R1 to R10 are specified organic groups and n and is 0, 1, 2, 3 or 4; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.
摘要:
The use of a compound of formula (I) wherein X is (i), (ii) or (iii), formula (i),formula (ii), formula (iii) Y is O, S(O)m, NR3, CR5R6, CR5R6-CR7R8, O-CR7R8, S(O)m-CR7R8, NR3-CR7R8, CR5R6 -O, CR5R6-S(O)m, CR5R6-NR3, SO2-NR3, NR3-SO2, NR3-O or O-NR3; m is 0, 1, or 2; the ring (T) formula (T) is a 5- or 6-membered aromatic or heteroaromatic ring; R1 to R10 are specified organic groups and n and is 0, 1, 2, 3 or 4; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.
摘要:
The invention provides a novel alkylenediamine derivative which shows a function of relieving urinating contraction. The novel alkylenediamine derivative of the invention has the following formula (1): in which R 1 is hydrogen, alkyl, halogen, haloalkyl, hydroxyl, alkoxy, nitro, amino, cyano, etc.; R 2 is hydrogen, alkyl, aryl, etc.,; R 3 and R 4 each is alkyl, etc., or R 3 and R 4 may be combined to form a heterocyclic group which may have substituents; k is an integer of 1-4; m and n each is an integer of 0-4; p+q is 0-4 in which p is 0, 1 or 2, and q is 0 or 1; w, x, y and z each is an integer of 0-2, under the condition of w+x+y+z is 1 or 2; and w+x+y+z can be 0, if R 1 through R 4 are groups within certain determined groups.
摘要翻译:本发明提供了一种显示出缓解排尿功能的新型亚烷基二胺衍生物。 本发明的新型亚烷基二胺衍生物具有下式(1):其中R1为氢,烷基,卤素,卤代烷基,羟基,烷氧基,硝基,氨基,氰基等; R2为氢,烷基,芳基等; R3和R4各自为烷基等,或者R3和R4可以结合形成可以具有取代基的杂环基; k是1-4的整数; m和n各自是0-4的整数; p + q是0-4,其中p是0,1或2,并且q是0或1; w,x,y和z各自为0-2的整数,在w + x + y + z为1或2的条件下; 并且如果R1至R4是某些确定组内的组,则w + x + y + z可以是0。
摘要:
The present invention relates to the discovery that certain non-naturally occurring, non-peptide arride compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or trite enhancer, more particularly, savory (the "umami" taste of monosodium glutamate) or sweet taste modifiers, - savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.
摘要:
Disclosed in the present invention is a novel histone deacetylase inhibitor of benzamides and use thereof. The inhibitor has good efficacy in treating diseases caused by abnormal gene expression, such as tumours, endocrine disorders, immune system diseases, genetic diseases and nerve system diseases. The histone deacetylase inhibitor of benzamides is a compound of the following general chemical structural formula (I) or a salt thereof.
摘要:
A novel alkylenediamine derivative having the effect of inhibiting dysuria occuring under a high intravesical pressure and represented by general formula (1) wherein R1 represents hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, nitro, amino, cyano, etc.; R2 represents hydrogen, alkyl, aryl, etc.; R?3 and R4¿ represent each alkyl, etc., or R?3 and R4¿ are combined together to form an optionally substituted heterocyclic group; k represents an integer of 1 to 4; m an n represent each an integer of 0 to 4; p+q = 0 to 4, wherein p is 0, 1 or 2 and q is 0 or 1; and w, x, y and z represent each an integer of 0 to 2, and w+x+y+z = 1 or 2, provided when R1 to R4 represent each a specifically limited group, w+x+y+z may be 0.
摘要:
Disclosed in the present invention is a novel histone deacetylase inhibitor of benzamides and use thereof. The inhibitor has good efficacy in treating diseases caused by abnormal gene expression, such as tumours, endocrine disorders, immune system diseases, genetic diseases and nerve system diseases. The histone deacetylase inhibitor of benzamides is a compound of the following general chemical structural formula (I) or a salt thereof.