公开(公告)号：EP2010556B1

公开(公告)日：2015-09-23

申请号：EP07755136.4

申请日：2007-04-11

申请人： Sloan-Kettering Institute for Cancer Research

发明人： DANISHEFSKY, Samuel J. ,  WARREN, J. David ,  CHEN, Jiehao ,  WU, Bin ,  CHEN, Gong ,  WAN, Qian ,  TAN, Zhongping ,  KAN, Cindy ,  YUAN, Yu ,  HUA, Zihao ,  RANGANATHAN, Krishnakumar ,  TRZUPEK, John D.

IPC分类号： C07K14/505 ,  A61K38/16

CPC分类号： C07K14/505 ,  C07K9/00 ,  C12P21/005

公开(公告)号：EP2315771A2

公开(公告)日：2011-05-04

申请号：EP09795292.3

申请日：2009-07-13

申请人： Sloan Kettering Institute For Cancer Research

发明人： DANISHEFSKY, Samuel ,  ZHU, Jianglong ,  WAN, Qian ,  JEON, Insik ,  KIM, Wooham ,  NAGORNY, Pavel ,  LEE, Dongjoo ,  LIVINGSTON, Philip ,  RAGUPATHI, Govind

IPC分类号： C07K9/00 ,  A61K38/14 ,  A61P35/00

CPC分类号： C07K9/001 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/6081 ,  A61K2039/6093 ,  C07K9/006

摘要： Glycopeptide conjugates, and methods of making and using such conjugates are disclosed. Certain glycopeptide conjugates comprise tumor associated carbohydrate antigens and peptide epitopes. Certain glycopeptide conjugates comprise cyclic peptide scaffolds that display carbohydrate antigens in a clustered fashion. The immunogenicity of select glycopeptide conjugates is demonstrated.

摘要翻译： 公开了糖肽缀合物，以及制备和使用这种缀合物的方法。 某些糖肽缀合物包含肿瘤相关的碳水化合物抗原和肽表位。 某些糖肽缀合物包含以成簇方式展示碳水化合物抗原的环肽支架。 证明了选择的糖肽缀合物的免疫原性。

公开(公告)号：EP2010556A2

公开(公告)日：2009-01-07

申请号：EP07755136.4

申请日：2007-04-11

申请人： Sloan-Kettering Institute for Cancer Research

发明人： DANISHEFSKY, Samuel J. ,  WARREN, J. David ,  CHEN, Jiehao ,  WU, Bin ,  CHEN, Gong ,  WAN, Qian ,  TAN, Zhongping ,  KAN, Cindy ,  YUAN, Yu ,  HUA, Zihao ,  RANGANATHAN, Krishnakumar ,  TRZUPEK, John D.

IPC分类号： C07K14/00 ,  A61K38/00 ,  A61K38/16

CPC分类号： C07K14/505 ,  C07K9/00 ,  C12P21/005

摘要： The present invention provides isolated homogeneous polyfunctionalized proteins (e.g., erythropoietin), isolated glycopeptides, and a method for preparing polyfunctionalized peptides and/or proteins via cysteine-free native chemical ligation. In certain embodiments, the invention provides an isolated homogeneous polyfunctionalized protein having the structure (I). In certain other embodiments, the invention provides an isolated glycopeptide having Formula (II). In certain other embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently substituted with a moiety having the structure (III) -LH. wherein A and L1 are as defined herein.