-
公开(公告)号：EP1448545B1
公开(公告)日：2008-11-19
申请号：EP02800491.9
申请日：2002-10-04
IPC分类号： C07D333/36 , A61K31/38
CPC分类号： C07D333/36 , C07D333/38
摘要： The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IλB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-λB in which diseases excessive activation of NF-λB is implicated.
-
公开(公告)号：EP1499320B1
公开(公告)日：2007-08-22
申请号：EP03721779.1
申请日：2003-04-18
IPC分类号： C07D487/00 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04
摘要： Novel substituted 2, 4, 8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
-
公开(公告)号：EP1448545A1
公开(公告)日：2004-08-25
申请号：EP02800491.9
申请日：2002-10-04
IPC分类号： C07D333/36 , A61K31/38
CPC分类号： C07D333/36 , C07D333/38
摘要： The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IλB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-λB in which diseases excessive activation of NF-λB is implicated.
-
公开(公告)号：EP1805132A2
公开(公告)日：2007-07-11
申请号：EP05857821.2
申请日：2005-10-05
IPC分类号： C07C233/05 , C07C229/00 , C07D211/22 , C07D241/04 , C07D277/04 , A61K31/165 , A61K31/195 , A61K31/445 , A61K31/425 , A61K31/495
CPC分类号： C07C233/65 , C07C233/63 , C07C233/69 , C07C233/78 , C07C275/42 , C07C2601/02 , C07D211/58 , C07D213/75 , C07D277/46
摘要： The present invention is directed to novel compounds of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译： 本发明涉及新颖的式（I）化合物或其药学上可接受的衍生物及其作为药物，特别是作为p38激酶抑制剂的用途。
-
公开(公告)号：EP1601360A2
公开(公告)日：2005-12-07
申请号：EP04706434.0
申请日：2004-01-29
发明人： KERNS, Jeffrey , JIN, Qi , WAN, Zehong , NIE, Hong , ZHU, Chongjie
IPC分类号： A61K31/496 , A61K31/5377 , C07D401/06 , C07D403/14 , C07D413/14
CPC分类号： C07D409/14
摘要： Compounds of formula (I) are disclosed which are NK2 and NK3 receptor antagonists and are useful in the treatment of respiratory diseases, or a pharmaceutically acceptable salt thereof.
摘要翻译： 公开了式（I）化合物，它们是NK2和NK3受体拮抗剂并可用于治疗呼吸系统疾病，或其药学上可接受的盐。
-
公开(公告)号：EP1605944A2
公开(公告)日：2005-12-21
申请号：EP04706441.5
申请日：2004-01-29
发明人： KERNS, Jeffrey , JIN, Qi , YAN, Hongxing , WAN, Zehong
IPC分类号： A61K31/496 , C07D401/06
CPC分类号： C07D401/06
摘要： Compounds of the formula (I) are disclosed which are NK2 and NK3 receptor antagonists and are useful in the treatment of respiratory diseases: or a pharmaceutically acceptable salt thereof.
-
公开(公告)号：EP1551410A2
公开(公告)日：2005-07-13
申请号：EP03794501.1
申请日：2003-08-26
IPC分类号： A61K31/52 , A61K31/522 , C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
CPC分类号： C07D487/04 , C07D473/34
摘要： Novel substituted pyrrolo[2.3-d]pyrimidin-4-yl compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
摘要翻译： 新的取代的吡咯并[2,3-d]嘧啶-4-基化合物和用于作为CSBP / p38激酶抑制剂治疗的组合物。
-
公开(公告)号：EP1532135B1
公开(公告)日：2007-04-04
申请号：EP03731435.8
申请日：2003-05-29
发明人： CALLAHAN, James, F. , WAN, Zehong
IPC分类号： C07D333/52 , A61K31/381 , C07D333/68 , A61P29/00 , A61P19/00
CPC分类号： C07D333/68
摘要： The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK- beta phosphorylation of I kappa B. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF- kappa B in which diseases excessive activation of NF- kappa B is implicated.
-
公开(公告)号：EP1532135A1
公开(公告)日：2005-05-25
申请号：EP03731435.8
申请日：2003-05-29
发明人： CALLAHAN, James, F. , WAN, Zehong
IPC分类号： C07D333/52 , A61K31/381
CPC分类号： C07D333/68
摘要： The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK- beta phosphorylation of I kappa B. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF- kappa B in which diseases excessive activation of NF- kappa B is implicated.
摘要翻译： 本发明提供了新型化合物和使用它们治疗IKK-β的IKK-β磷酸化的氨基噻吩抑制剂治疗疾病的方法。这样，这些氨基噻吩抑制剂阻断转录因子NF-κB的病理活化，其中疾病的NF过度活化 - 卡帕B牵连。
-
公开(公告)号：EP1499320A1
公开(公告)日：2005-01-26
申请号：EP03721779.1
申请日：2003-04-18
IPC分类号： A61K31/519 , A01N43/90 , C07D487/00
CPC分类号： C07D471/04
摘要： Novel substituted 2, 4, 8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
摘要翻译： 新取代的2,4,8-三取代的-8H-吡啶并[2,3-d]嘧啶-7-酮化合物和组合物，用于治疗作为CSBP / p38激酶抑制剂。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.015 秒)
