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公开(公告)号：EP1448545B1
公开(公告)日：2008-11-19
申请号：EP02800491.9
申请日：2002-10-04
IPC分类号： C07D333/36 , A61K31/38
CPC分类号： C07D333/36 , C07D333/38
摘要： The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IλB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-λB in which diseases excessive activation of NF-λB is implicated.
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公开(公告)号：EP1169317A1
公开(公告)日：2002-01-09
申请号：EP00930101.1
申请日：2000-04-06
IPC分类号： C07D401/04 , C07D413/04 , C07D405/14 , A61K31/4178 , A61P19/00
CPC分类号： C07D401/04 , C07D405/14 , C07D413/04
摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R2 and R3 are various substituent groups; and one of X1 and X2 is N or CR', and the other is NR' or CHR' wherein R' is hydrogen, OH, C1-6alkyl, or C3-7cycloalkyl; or when one of X1 and X2 is N or CR' then the other may be S or O; and their use as pharmaceuticals.
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公开(公告)号：EP1070048B1
公开(公告)日：2005-08-31
申请号：EP99916516.0
申请日：1999-04-08
发明人： BHATNAGAR, Pradip, Kumar , BURGESS, Joelle, Lorraine , CALLAHAN, James, Francis , CALVO, Raul, Rolando , DEL MAR, Eric, G. , LAGO, Maria, Amparo , NGUYEN, Thomas, The
IPC分类号： C07C255/33 , C07C217/56 , C07C217/32 , C07C255/55 , C07C217/90 , C07C311/06 , C07D209/48 , A61K31/195 , A61K31/275 , A61K31/40 , A61K31/135 , A61K31/215
CPC分类号： C07D209/48 , C07C217/22 , C07C217/60 , C07C255/37 , C07C255/54 , C07C255/57 , C07C311/06
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公开(公告)号：EP0973730A1
公开(公告)日：2000-01-26
申请号：EP98914581.8
申请日：1998-04-08
发明人： BARMORE, Robert, M. , BHATNAGAR, Pradip, Kumar , BRYAN, William, M. , BURGESS, Joelle, Lorraine , CALLAHAN, James, Francis , CALVO, Raul, Rolando , DEL MAR, Eric, G. , LAGO, Maria Amparo , NGUYEN, Thomas, The , SHEEHAN, Derek , SMITH, Robert, Lawrence , SOUTHALL, Linda, Sue , VAN WAGENEN, Bradford, C.
IPC分类号： C07C255/07 , C07C311/03 , C07C229/04 , C07C69/76 , C07C69/74 , C07D223/08 , C07D243/12 , C07D273/04 , C07D265/30 , C07D295/092 , C07D413/08
CPC分类号： C07D295/192 , C07C255/57 , C07C311/08 , C07C311/21 , C07C311/29 , C07C323/17 , C07C2601/02 , C07C2603/32 , C07D267/20 , C07D295/215
摘要： Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
摘要翻译： 提供了表现出钙溶解性质的新型芳基烷基氨基化合物。
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公开(公告)号：EP1448545A1
公开(公告)日：2004-08-25
申请号：EP02800491.9
申请日：2002-10-04
IPC分类号： C07D333/36 , A61K31/38
CPC分类号： C07D333/36 , C07D333/38
摘要： The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IλB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-λB in which diseases excessive activation of NF-λB is implicated.
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公开(公告)号：EP0973730B1
公开(公告)日：2004-06-16
申请号：EP98914581.8
申请日：1998-04-08
发明人： BARMORE, Robert, M. , BHATNAGAR, Pradip, Kumar , BRYAN, William, M. , BURGESS, Joelle, Lorraine , CALLAHAN, James, Francis , CALVO, Raul, Rolando , DEL MAR, Eric, G. , LAGO, Maria Amparo , NGUYEN, Thomas, The , SHEEHAN, Derek , SMITH, Robert, Lawrence , SOUTHALL, Linda, Sue , VAN WAGENEN, Bradford, C.
IPC分类号： C07C321/22 , C07C311/20 , C07C311/16 , C07C311/08 , C07C255/56 , C07C255/54 , C07C217/58 , C07C217/34 , C07C217/36 , C07D295/26 , C07D295/18 , C07D295/104 , C07D295/092 , C07D267/20 , A61P19/08 , A61P19/10 , A61K31/18 , A61K31/165
CPC分类号： C07D295/192 , C07C255/57 , C07C311/08 , C07C311/21 , C07C311/29 , C07C323/17 , C07C2601/02 , C07C2603/32 , C07D267/20 , C07D295/215
摘要： Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
摘要翻译： 提供了具有钙质特性的新型芳基烷基氨基化合物。
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公开(公告)号：EP1169317B1
公开(公告)日：2003-01-15
申请号：EP00930101.1
申请日：2000-04-06
IPC分类号： C07D401/04 , C07D413/04 , C07D405/14 , A61K31/4178 , A61P19/00
CPC分类号： C07D401/04 , C07D405/14 , C07D413/04
摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R2 and R3 are various substituent groups; and one of X1 and X2 is N or CR', and the other is NR' or CHR' wherein R' is hydrogen, OH, C1-6alkyl, or C3-7cycloalkyl; or when one of X1 and X2 is N or CR' then the other may be S or O; and their use as pharmaceuticals.
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公开(公告)号：EP1070048A1
公开(公告)日：2001-01-24
申请号：EP99916516.0
申请日：1999-04-08
发明人： BHATNAGAR, Pradip, Kumar , BURGESS, Joelle, Lorraine , CALLAHAN, James, Francis , CALVO, Raul, Rolando , DEL MAR, Eric, G. , LAGO, Maria, Amparo , NGUYEN, Thomas, The
IPC分类号： C07C255/33
CPC分类号： C07D209/48 , C07C217/22 , C07C217/60 , C07C255/37 , C07C255/54 , C07C255/57 , C07C311/06
摘要： Novel calcilytic compounds, pharmaceutical compositions containing said compounds and their use as calcium receptor antagonists.
摘要翻译： 新型钙溶解化合物，含有所述化合物的药物组合物及其作为钙受体拮抗剂的用途。
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