公开(公告)号：EP2150255A1

公开(公告)日：2010-02-10

申请号：EP08747837.6

申请日：2008-05-08

申请人： Smithkline Beecham Corporation

发明人： CHAUDHARI, Amita ,  DHANAK, Dashyant ,  DONATELLI, Carla, Ann ,  FAITG, Thomas, H. ,  FENG, Yanhong ,  KNIGHT, Steven, David ,  PARRISH, Cynthia, A. ,  RALPH, Jeffrey, M. ,  SARPONG, Martha, A. ,  SILVA, Domingos, J.

IPC分类号： A61K31/495

CPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D417/14

摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.

公开(公告)号：EP1962830A2

公开(公告)日：2008-09-03

申请号：EP06846678.8

申请日：2006-12-19

申请人： SmithKline Beecham Corporation

发明人： ADAMS, Jerry, Leroy ,  ADAMS, Nicholas, D. ,  AXTEN, Jeffrey, Michael ,  CHAUDHARI, Amita, M. ,  DHANAK, Dashyant ,  HAMAJIMA, Toshihiro ,  NEWLANDER, Kenneth, Allen ,  PARRISH, Cynthia, A. ,  SARPONG, Martha, A. ,  SILVA, Domingos, J. ,  TANG, Jun

IPC分类号： A61K31/335

CPC分类号： C07D471/04

摘要： The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.

公开(公告)号：EP1333833A2

公开(公告)日：2003-08-13

申请号：EP01994463.6

申请日：2001-10-23

申请人： SmithKline Beecham Corporation

发明人： ADAMS, Jerry, L. ,  BOEHM, Jeffrey, C. ,  HALL, Ralph ,  JIN, Qi ,  KASPAREC, Jiri ,  SILVA, Domingos, J. ,  TAGGART, John, J.

IPC分类号： A61K31/505 ,  A61P19/00 ,  A61P31/00 ,  C07D239/02 ,  C07D471/02

CPC分类号： C07D239/47 ,  C07D471/04

摘要： Novel substituted 2,4,8-trisubstituted -8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.

公开(公告)号：EP2121637A1

公开(公告)日：2009-11-25

申请号：EP08728247.1

申请日：2008-01-25

申请人： Smithkline Beecham Corporation

发明人： AXTEN, Jeffrey, Michael ,  BRYAN, Deborah, L. ,  DREWRY, David, Harold ,  FAITG, Thomas, H. ,  GALLAGHER, Thimothy, Francis ,  JOHNSON, Neil, W. ,  KASPAREC, Jiri ,  RALPH, Jeffrey, M. ,  SILVA, Domingos, J.

IPC分类号： C07D241/04 ,  A61K31/496 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D241/20 ,  C07D413/12

摘要： The present invention relates to a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof; where R1, R2, R3, R4, r and s are as previously defined. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.

公开(公告)号：EP1509218A1

公开(公告)日：2005-03-02

申请号：EP03756286.5

申请日：2003-05-30

申请人： SmithKline Beecham Corporation

发明人： AUBART, Kelly, M. ,  BENOWITZ, Andrew, B. ,  CHRISTENSEN, Siegfried, B., IV ,  KARPINSKI, Joseph, M. ,  LEE, Jinhwa ,  SILVA, Domingos, J.

IPC分类号： A61K31/16 ,  A61K31/18 ,  A61K31/44 ,  A61K31/50 ,  A61K31/505 ,  A61K31/495 ,  C07C243/22 ,  C07C311/16 ,  C07D213/77 ,  C07D237/22 ,  C07D239/42

CPC分类号： C07C259/06 ,  C04B35/632 ,  C07C311/39 ,  C07D213/77 ,  C07D215/12 ,  C07D237/20 ,  C07D239/42 ,  C07D239/48 ,  C07D239/70 ,  C07D239/95 ,  C07D241/44 ,  C07D251/18 ,  C07D251/22 ,  C07D253/10 ,  C07D307/81 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04

摘要： Novel PDF inhibitors and novel methods for their use are provided.

公开(公告)号：EP1917258A2

公开(公告)日：2008-05-07

申请号：EP06802071.8

申请日：2006-08-23

申请人： SmithKline Beecham Corporation

发明人： ADAMS, Jerry, Leroy ,  FAITG, Thomas, H. ,  RALPH, Jeffrey, M. ,  SILVA, Domingos, J.

IPC分类号： C07D403/04 ,  C07D403/14 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D403/04

摘要： The present invention provides a compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a combination thereof, wherein the substituents are as defined herein. The present invention also relates to a composition comprising the compound of formula (I) and diluents, carriers, or excipients. Furthermore, the present invention relates to a method of treating a disease of cell proliferation comprising administering to a patient in need thereof a pharmaceutically effective amount of the compound of formula (I) or a salt thereof, or a solvate thereof, or a combination thereof.

公开(公告)号：EP1654239A2

公开(公告)日：2006-05-10

申请号：EP04781288.8

申请日：2004-08-12

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： AUBART, Kelly, M. ,  BENOWITZ, Andrew, B. ,  CHRISTENSEN, Siegfried, Benjamin, IV ,  LEE, Jinhwa ,  SILVA, Domingos, J.

IPC分类号： C07D245/00 ,  A61P31/04

CPC分类号： C07D487/08

摘要： Novel PDF inhibitors and novel methods for their use are provided.