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1.
公开(公告)号:EP3655403A1
公开(公告)日:2020-05-27
申请号:EP18835238.9
申请日:2018-07-23
申请人: Versitech Limited
发明人: KAO, Yi Tsun Richard , GAO, Peng , LI, Xuechen , LIU, Ming
IPC分类号: C07D417/00 , C07D419/00 , A61K31/425 , A61K31/44 , A61P31/04 , A61P31/00
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公开(公告)号:EP2476667B1
公开(公告)日:2014-07-16
申请号:EP12163855.5
申请日:2004-02-26
申请人: Sugen, Inc.
发明人: Cui, Jingjong, Jean , Johnson, Joanne , Kolodziej, Stephen, A. , Kung, Pei-Pei , Li, Xiaoyuan (Sharon) , Lin, Jason (Qishen) , Meng, Jerry Jialun , Nambu, Mitchell David , Nelson, Christopher G. , Pairish, Mason Alan , Shen, Hong , Zhang, Jennifer , Tran-Dube, Michelle , Walter, Allison , Zhang, Fang-Jie , Hanau, Cathleen Elizabeth , Bhumralkar, Dilip , Botrous, Iriny , Chu, Ji Yu , Funk, Lee A. , Harris Jr., G. Davis , Jia, Lei
IPC分类号: C07D213/73 , A61K31/4965 , C07D401/00 , C07D413/00 , C07D211/72 , A61K45/06 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D417/00 , C07D419/00 , A61P35/00 , C07D401/12 , C07D413/12
CPC分类号: C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
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3.BIPYRIDYL AMIDES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 审中-公开
标题翻译: METABOTROPEM谷氨酸受体5 BIPYRIDYLAMIDE AS调节剂公开(公告)号:EP1715867A4
公开(公告)日:2009-04-15
申请号:EP05713111
申请日:2005-02-09
申请人: MERCK & CO INC
IPC分类号: C07D213/81 , A61K31/44 , A61K31/4965 , A61P25/16 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07F7/08
CPC分类号: C07D401/12 , C07D213/81 , C07D241/26 , C07D401/14 , C07D405/14 , C07D409/14 , C07F7/0812
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公开(公告)号:EP1811844A1
公开(公告)日:2007-08-01
申请号:EP05814012.0
申请日:2005-09-14
发明人: BAMDAD, Cynthia C.
IPC分类号: A01N43/54 , A61K31/517 , C07D419/00 , C07D239/72 , A61K31/495 , C07D209/00 , C07D209/48
CPC分类号: A61K31/495 , A61K31/517 , B82Y30/00
摘要: The present application discloses methods of detecting and treating cancer which express MUC1 aberrantly.
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公开(公告)号:EP1663237A2
公开(公告)日:2006-06-07
申请号:EP04788717.9
申请日:2004-09-10
申请人: Icagen, Inc.
IPC分类号: A61K31/497 , A61K31/517 , A01N43/54 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号: C04B35/632 , C07D239/92 , C07D285/24 , C07D401/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions. .
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公开(公告)号:EP1539178A2
公开(公告)日:2005-06-15
申请号:EP03751880.0
申请日:2003-08-22
发明人: BONDINELL, William, E. , HALL, Ralph, F. , JIN, Qi , KERNS, Jeffrey, K. , NIE, Hong , WIDDOWSON, Katherine, L.
IPC分类号: A61K31/55 , A61P31/00 , C07D223/08 , C07D401/00 , C07D403/00 , C07D405/00 , C07D413/00 , C07D415/00 , C07D417/00 , C07D419/00
CPC分类号: H04L27/2601 , C07D223/08 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要: This invention relates 4-amino-azepan-3-ones of formula (1) which are useful as protease inhibitors, particularly of cathepsin S, and as such are useful for preventing a number of diseases amongst which are atherosclerotic lesions and pulmonary diseases such as asthma and allergic reactions.
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公开(公告)号:EP3971177A1
公开(公告)日:2022-03-23
申请号:EP21202619.9
申请日:2017-07-18
申请人: Novartis AG
发明人: LI, Jialiang , ARISTA, Luca , BABU, Sreehari , BIAN, Jianwei , CUI, Kai , DILLON, Michael Patrick , LATTMANN, Rene , LIAO, Lv , RAMOS, Rita , STIEFL, Nikolaus Johannes , ULLRICH, Thomas , USSELMANN, Peggy , WANG, Xiaoyang , WAYKOLE, Liladhar Murlidhar , WEILER, Sven , ZHANG, Yubo , ZHOU, Yizong , ZHU, Tingying , LIZOS, Dimitrios
IPC分类号: C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D411/14 , C07D413/00 , C07D417/00 , C07D419/00 , A61K31/4427 , A61P19/00
摘要: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.
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公开(公告)号:EP3487851B1
公开(公告)日:2021-10-20
申请号:EP17830463.0
申请日:2017-07-18
发明人: LI, Jialiang , ARISTA, Luca , BABU, Sreehari , BIAN, Jianwei , CUI, Kai , DILLON, Michael Patrick , LATTMANN, Rene , LIAO, Lv , LIZOS, Dimitrios , RAMOS, Rita , STIEFL, Nikolaus Johannes , ULLRICH, Thomas , USSELMANN, Peggy , WANG, Xiaoyang , WAYKOLE, Liladhar Murlidhar , WEILER, Sven , ZHANG, Yubo , ZHOU, Yizong , ZHU, Tingying
IPC分类号: C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D411/14 , C07D413/00 , C07D417/00 , C07D419/00 , A61K31/4427 , A61P19/00
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公开(公告)号:EP3487851A1
公开(公告)日:2019-05-29
申请号:EP17830463.0
申请日:2017-07-18
申请人: Novartis AG
发明人: LI, Jialiang , ARISTA, Luca , BABU, Sreehari , BIAN, Jianwei , CUI, Kai , DILLON, Michael Patrick , LATTMANN, Rene , LIAO, Lv , LIZOS, Dimitrios , RAMOS, Rita , STIEFL, Nikolaus Johannes , ULLRICH, Thomas , USSELMANN, Peggy , WANG, Xiaoyang , WAYKOLE, Liladhar Murlidhar , WEILER, Sven , ZHANG, Yubo , ZHOU, Yizong , ZHU, Tingying
IPC分类号: C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D411/14 , C07D413/00 , C07D417/00 , C07D419/00 , A61K31/4427 , A61P19/00
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公开(公告)号:EP2322501B1
公开(公告)日:2015-08-05
申请号:EP10183340.8
申请日:2003-01-06
发明人: Nelson, Mark L. , Ohemeng, Kwasi
IPC分类号: C07C235/70 , C07C235/32 , C07D209/02 , C07D265/30 , C07D333/50 , C07D419/00 , A61K31/65 , A61P31/04
CPC分类号: A61K31/65 , C07C235/70 , C07C237/26 , C07C251/48 , C07C255/41 , C07C271/22 , C07C271/54 , C07C271/58 , C07C275/42 , C07C275/54 , C07C279/18 , C07C311/06 , C07C311/08 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07D295/185 , C07D317/60 , C07F9/2475 , C07F9/4006
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