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1.发明公开PROLIFERATION-ASSOCIATED MODULATION OF THE SPLICING OF THE INTEGRIN ALPHA 6 ISOFORMS 有权整联ALPHA-6-异构体增殖相关调制剪接
公开(公告)号：EP2370109A1
公开(公告)日：2011-10-05
申请号：EP09831355.4
申请日：2009-12-10
IPC分类号： A61K48/00 , A61K31/7088 , A61K38/17 , A61K45/00 , A61P35/00 , C12Q1/68 , G01N33/567 , G01N33/574 , G01N33/68 , C12N15/63 , C12N15/85
CPC分类号： C12N15/87 , A61K31/00 , A61K31/7088 , A61K38/1777 , C12N15/113 , C12N2310/14 , C12N2799/027 , G01N33/574 , G01N2333/70546
摘要： This application relates to the use of agents such as expression vectors and nucleic acids encoding integrins α6 A or α6B as well as antibodies specific for those integrins which are capable of modulating the ratio between the B and A isoforms of the α6 integrin in the treatment of diseases associated with an altered proliferation rate, such as cancer. The application also relates to the use of the ratio between the B and A isoforms of the α6 integrin in the diagnosis of diseases associated with an altered proliferation rate.
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2.发明授权PROLIFERATION-ASSOCIATED MODULATION OF THE SPLICING OF THE INTEGRIN ALPHA 6 ISOFORMS 有权整联ALPHA-6-异构体增殖相关调制剪接
公开(公告)号：EP2370109B1
公开(公告)日：2014-02-26
申请号：EP09831355.4
申请日：2009-12-10
IPC分类号： A61K31/7088 , A61K38/17 , A61P35/00 , C12Q1/68 , G01N33/574 , G01N33/68 , C12N15/113
CPC分类号： C12N15/87 , A61K31/00 , A61K31/7088 , A61K38/1777 , C12N15/113 , C12N2310/14 , C12N2799/027 , G01N33/574 , G01N2333/70546
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