公开(公告)号：EP2370109A4

公开(公告)日：2012-09-26

申请号：EP09831355

申请日：2009-12-10

申请人： SOCPRA SCIENCES SANTE ET HUMAINES S E C

发明人： BEAULIEU JEAN-FRANCOIS ,  HERRING ELIZABETH ,  BASORA NURIA ,  GROULX JEAN-FRANCOIS

IPC分类号： A61K48/00 ,  A61K31/7088 ,  A61K38/17 ,  A61K45/00 ,  A61P35/00 ,  C12N15/63 ,  C12N15/85 ,  C12Q1/68 ,  G01N33/567 ,  G01N33/574 ,  G01N33/68

CPC分类号： C12N15/87 ,  A61K31/00 ,  A61K31/7088 ,  A61K38/1777 ,  C12N15/113 ,  C12N2310/14 ,  C12N2799/027 ,  G01N33/574 ,  G01N2333/70546

公开(公告)号：EP2015769A2

公开(公告)日：2009-01-21

申请号：EP07755526.6

申请日：2007-04-13

申请人： Societe de Conseils de Recherches et d'Applications Scientifique

发明人： CHERIF-CHEIKH, Roland ,  DONG, Zheng, Xin ,  TOBALINA MAESTRE, Maria, Dolores ,  CORDERO-RIGOL, Jose-antono ,  LACOMBE, Frederic

IPC分类号： A61K38/26 ,  A61K38/17

CPC分类号： A61K38/2278 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/10 ,  A61K33/24 ,  A61K38/1777 ,  A61K38/26 ,  A61K2300/00

摘要： The present invention is directed to pharmaceutical composition comprising a clear solution or an aqueous mixture, a suspension or a semisolid of at least one peptide compound selected from the group consisting of hGLP-1(7-36)-NH2 and analogs and derivatives thereof, hGLP-1(7-37)-OH and analogs and derivatives thereof and/or exendin-4 and analogs and derivatives thereof, zinc and solvent wherein at least 95% of the said peptide compound is dissolved by the solvent.

公开(公告)号：EP1755660A2

公开(公告)日：2007-02-28

申请号：EP05804812.5

申请日：2005-05-06

申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

发明人： CLEMMONS, David, R. ,  MAILE, Laura, A.

IPC分类号： A61K39/00

CPC分类号： G01N33/5011 ,  A61K38/1777 ,  C07K14/78 ,  C07K16/2848 ,  C07K2317/34 ,  G01N2333/65 ,  G01N2333/70557 ,  G01N2500/04

摘要： The present invention provides aVß3 integrin cysteine loop domain agonists and antagonists (including peptide agonists and antagonists and analogs thereof), along with methods of using the same.

摘要翻译： 本发明提供了αVβ3整联蛋白半胱氨酸环结构域激动剂和拮抗剂（包括肽激动剂和拮抗剂及其类似物）以及使用它们的方法。

公开(公告)号：EP1124572B1

公开(公告)日：2003-09-10

申请号：EP99970605.4

申请日：1999-10-22

申请人： Curagen Corporation

发明人： SHIMKETS, Richard, A.

IPC分类号： A61K38/43 ,  A61K38/21 ,  A61K38/17 ,  A61K48/00 ,  A61K39/395 ,  G01N33/50 ,  C12Q1/70 ,  C12N15/12 ,  C12N15/52 ,  A61P13/12 ,  A01K67/027

CPC分类号： G01N33/5091 ,  A01K2217/052 ,  A01K2267/03 ,  A61K38/1709 ,  A61K38/1748 ,  A61K38/177 ,  A61K38/1777 ,  A61K38/215 ,  A61K38/44 ,  A61K38/45 ,  A61K38/46 ,  A61K38/4813 ,  A61K38/4853 ,  A61K38/57 ,  A61K45/06 ,  A61K2039/505 ,  C12Y304/11002 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5023 ,  A61K2300/00

摘要： The present invention discloses 16 genes that are differentially expressed in animal models of hypertension relative to non-hypertensive controls. In particular, 16 genes were identified which are differentially-expressed in the fawn-hooded rat (FHR) and the closely-related IRL rat strain, in comparison to the control ACI strain of rat. Also disclosed are therapeutic and prophylactic methods for treating or preventing renal failure, platelet storage-pool disease, hypertension, insulin-dependent diabetes mellitus (IDDM) and/or other associated diseases or disorders using these genes and nucleic acids encoding these genes. Methods for diagnosis, prognosis, and screening, by the detection of the differentially-expressed proteins and nucleic acids, as well as derivatives, fragments and analogs thereof, are also disclosed herein.

公开(公告)号：EP1333843A2

公开(公告)日：2003-08-13

申请号：EP01989905.3

申请日：2001-11-05

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  The Center for Blood Research, INC.

发明人： STOSSEL, Thomas, P. ,  HARTWIG, John, H. ,  WAGNER, Denisa, D.

IPC分类号： A61K35/14

CPC分类号： G01N33/56972 ,  A61K35/19 ,  A61K38/1777 ,  G01N33/86

摘要： Compositions and methods for prolonging the survival of chilled platelets are provided. The compositions include agents which inhibit the liver macrophage binding to chilled platelets.

公开(公告)号：EP1267916A2

公开(公告)日：2003-01-02

申请号：EP01925576.9

申请日：2001-04-04

申请人： IPF Pharmaceuticals GmbH

发明人： KRAMER, Franz-Josef ,  MARK, Silke ,  STÄNDKER, Ludger ,  FORSSMANN, Wolf-Georg

IPC分类号： A61K38/48 ,  A61K38/17 ,  A61P19/00

CPC分类号： A61K38/57 ,  A61K38/1777

摘要： The invention relates to TIMP-2 as an osteo-anabolically active peptide for use as a medicament in the treatment of osseous defects, osteopathy and for improving bone regeneration.

公开(公告)号：EP3344257A1

公开(公告)日：2018-07-11

申请号：EP16770444.4

申请日：2016-08-24

申请人： Westfälische Wilhelms-Universität Münster

发明人： BITTNER, Stefan ,  MEUTH, Sven ,  WÜNSCH, Bernhard ,  SCHEPMANN, Dirk

IPC分类号： A61K31/55 ,  A61P37/06

CPC分类号： A61K31/55 ,  A61K31/135 ,  A61K31/164 ,  A61K31/57 ,  A61K38/1777 ,  A61K45/06 ,  A61K2300/00 ,  A61P37/02 ,  Y02A50/414

摘要： The present invention provides novel means and methods for treatment auf immunemediated inflammatory diseases.

公开(公告)号：EP2854829A1

公开(公告)日：2015-04-08

申请号：EP13727568.1

申请日：2013-05-30

申请人： Sensorion

发明人： GABOYARD-NIAY, Sophie

IPC分类号： A61K36/9068 ,  A61K38/39 ,  A61K45/06 ,  A61K31/12 ,  A61K31/137 ,  A61K31/138 ,  A61K31/155 ,  A61K31/165 ,  A61K31/192 ,  A61K31/277 ,  A61K31/282 ,  A61K31/403 ,  A61K31/4164 ,  A61K31/4168 ,  A61K31/435 ,  A61K31/4409

CPC分类号： A61K31/4439 ,  A61K31/282 ,  A61K31/341 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/555 ,  A61K33/24 ,  A61K38/1777 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a method for treating platinum drugs induced vestibulotoxicity, comprising administering a compound that impairs or prevents accumulation of platinum drugs within vestibular hair cells and/or vestibular primary neurons.

公开(公告)号：EP2703005A1

公开(公告)日：2014-03-05

申请号：EP12182994.9

申请日：2012-09-04

申请人： Università Degli Studi Di Torino ,  Fondazione Piemontese per la Ricerca sul Cancro-ONLUS

发明人： Bussolino, Federico. ,  Marchio, Serena.

IPC分类号： A61K38/17 ,  C12N15/00 ,  G01N33/00 ,  A61P35/04

CPC分类号： A61K38/177 ,  A61K38/1777 ,  C07K7/06 ,  C07K14/705 ,  C07K14/70546 ,  G01N33/57407 ,  G01N33/57419 ,  G01N2333/705 ,  G01N2333/70546 ,  G01N2500/00 ,  G01N2800/52

摘要： In one aspect, the invention relates to an inhibitor of the α 6 integrin/E-cadherin molecular complex for use as a medicament, in particular for the prevention or/and treatment of metastases of a primary cancer disease and a pharmaceutical composition or kit comprising as an active agent at least one of the inhibitors. In a further embodiment, the present invention relates to a method for determining the prognosis of metastatic homing of a primary cancer disease, in particular the aggressiveness of the metastatic potential of a primary cancer disease.

摘要翻译： 一方面，本发明涉及用作药物的±6整联蛋白/ E-钙粘蛋白分子复合物的抑制剂，特别是用于预防或/和治疗原发性癌症疾病的转移和药物组合物或试剂盒，其包含 作为至少一种抑制剂的活性剂。 在另一个实施方案中，本发明涉及一种用于确定原发性癌症疾病的转移归巢预后的方法，特别是原发性癌症疾病的转移潜力的侵袭性。

公开(公告)号：EP1755660A4

公开(公告)日：2007-07-18

申请号：EP05804812

申请日：2005-05-06

申请人： UNIV NORTH CAROLINA

发明人： CLEMMONS DAVID R ,  MAILE LAURA A

IPC分类号： A61K39/00 ,  A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  C07K14/78 ,  C07K16/28 ,  G01N33/50

CPC分类号： G01N33/5011 ,  A61K38/1777 ,  C07K14/78 ,  C07K16/2848 ,  C07K2317/34 ,  G01N2333/65 ,  G01N2333/70557 ,  G01N2500/04