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1.
公开(公告)号:EP3516046A1
公开(公告)日:2019-07-31
申请号:EP17771767.5
申请日:2017-09-22
申请人: Sorbonne Université , Centre National de la Recherche Scientifique , INSERM (Institut National de la Santé et de la Recherche Médicale)
发明人: DUEBEL, Jens , ADER, Marius , CHAFFIOL, Antoine , GARITA-HERNANDEZ, Marcela , LAMPIC, Marusa , DALKARA, Deniz , GOUREAU, Olivier , SAHEL, José-Alain
IPC分类号: C12N5/0793 , A61K35/30 , C12N15/85 , C12N15/861
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2.
公开(公告)号:EP3583204A1
公开(公告)日:2019-12-25
申请号:EP18708345.6
申请日:2018-02-16
申请人: Sorbonne Université , Centre National de la Recherche Scientifique , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号: C12N5/079 , C12N5/0797
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公开(公告)号:EP3761998A1
公开(公告)日:2021-01-13
申请号:EP19708546.7
申请日:2019-03-06
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4.METHODS FOR OBTAINING RETINAL PROGENITORS, RETINAL PIGMENTED EPITHELIAL CELLS AND NEURAL RETINAL CELLS 审中-公开
标题翻译: VERFAHREN ZUR HERSTELLUNG VONRETINAVORLÄUFERN,PIGMENTIERTEN RETINAEPITHELZELLEN UND NEURONALEN RETINAZELLEN公开(公告)号:EP2989200A1
公开(公告)日:2016-03-02
申请号:EP14726419.6
申请日:2014-04-25
IPC分类号: C12N5/0793 , C12N5/071 , C12N5/079
CPC分类号: C12N5/0621 , C12N5/062 , C12N5/0623 , C12N2501/115 , C12N2501/42 , C12N2502/1323 , C12N2506/03 , C12N2527/00 , C12N2533/54
摘要: The present invention pertains to a method for in vitro obtaining human retinal progenitors, comprising the steps of (i) placing an adherent culture of human pluripotent stem cells in a pro-neural medium; and (ii) maintaining this culture in said pro-neural medium until the appearance of pigmented cells and/or of neuroepithelial-like structures. Advantageously, additional steps can be performed to obtain RPE cells and/or precursors of the neural retina.
摘要翻译: 本发明涉及体外获得人视网膜祖细胞的方法,包括以下步骤:(i)将人多能干细胞的贴壁培养物置于前神经培养基中; 和(ii)在所述前神经培养基中维持该培养物,直到出现色素细胞和/或神经上皮样结构。 有利地,可以执行附加步骤以获得神经视网膜的RPE细胞和/或前体。
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