专利检索 ap:("Sparingvision") AND inv:"SAHEL, José-Alain" 第 1 页

1.

发明公开
CONSTRUCTS COMPRISING NEURONAL VIABILITY FACTORS AND USES THEREOF 审中-公开

公开(公告)号：EP3728610A1

公开(公告)日：2020-10-28

申请号：EP18826078.0

申请日：2018-12-21

申请人： Sparingvision , INSERM (Institut National de la Santé et de la Recherche Médicale) , SORBONNE UNIVERSITE

发明人： LEVEILLARD, Thierry , AÏT-ALI MAAMRI, Najate , BLOND, Frédéric , SAHEL, José-Alain , PUEL, Géraldine , CLERIN, Emmanuelle

IPC分类号： C12N15/86 , C07K14/435 , A61K48/00

2.

发明公开
G-PROTEIN-GATED-K+ CHANNEL-MEDIATED ENHANCEMENTS IN LIGHT SENSITIVITY IN PATIENTS WITH ROD-CONE DYSTROPHY (RCD) 审中-公开

公开(公告)号：EP4163296A1

公开(公告)日：2023-04-12

申请号：EP22200939.1

申请日：2022-10-11

申请人： Sparingvision

发明人： DALKARA, Deniz , SIMON, Cardillia-Joe , HERLITZE, Stephan , SAHEL, José-Alain , AUDO, Isabelle , PICAUD, Serge , BERTIN, Stéphane

IPC分类号： C07K14/705 , A61P27/02 , A61K38/17 , A61K48/00

摘要： The present invention concerns a new gene therapy approach to increase light-sensitivity in degenerating cones in advanced stages of rod-cone dystrophy (RCD) mediated by G-protein-gated-K+ channel (GIRK), in particular GIRK2, activated by G proteins recruited by cone opsin expressed in degenerating cones for use in the treatment of patients with RCD.