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    System for interactive interstitial photodynamic and phototermal tumor therapy and diagnosis
    1.
    发明公开
    System for interactive interstitial photodynamic and phototermal tumor therapy and diagnosis 有权
    系统中间体，光敏剂和光热敏剂Tumortherapie und-Diagnagn

    公开(公告)号：EP1955649A1

    公开(公告)日：2008-08-13

    申请号：EP08102902.7

    申请日：2002-11-11

    申请人： Spectracure AB

    发明人： Svanberg, Sune ,  Andersson-Engels, Stefan ,  Svanberg, Katarina

    IPC分类号： A61B5/00 ,  A61B5/22 ,  A61N5/06 ,  G02B26/08 ,  G02B6/36

    CPC分类号： A61N5/062 ,  A61B5/1455 ,  A61N5/0601 ,  A61N2005/0612 ,  A61N2005/063 ,  G02B6/3504 ,  G02B6/3556 ,  G02B6/4298

    摘要： A system for interactive interstitial photodynamic and photothermal tumor therapy and diagnosis is disclosed. The system comprises at least two primary radiation conductors at distal ends thereof interstitially inserted into a tumor; a diagnostic radiation source adapted to be activated and to transmit diagnostic radiation through at least one of said primary radiation conductors to the distal ends thereof, such that said diagnostic radiation is transmitted through tissue at said tumor site to distal ends of the remaining primary radiation conductors interstitially inserted into said tumor; a unit for collecting and evaluating diagnostic information from radiation received from said tumor ; a switching unit adapted to automatically switch between tumor therapy and tumor diagnostics; and a unit adapted to control said tumor therapy by regulating a therapeutical radiation intensity depending on said diagnostic information.

    摘要翻译： 公开了一种用于交互式间质光动力和光热肿瘤治疗和诊断的系统。 该系统包括在其远端端部插入肿瘤中的至少两个主辐射导体; 诊断辐射源，其适于被激活并且将诊断辐射通过所述主辐射导体中的至少一个发射到其远端，使得所述诊断辐射通过所述肿瘤部位的组织传播到剩余的一次辐射导体的远端 间插入所述肿瘤; 用于收集和评估来自所述肿瘤的辐射的诊断信息的单元; 适于在肿瘤治疗和肿瘤诊断之间自动切换的切换单元; 以及适于通过根据所述诊断信息调节治疗辐射强度来控制所述肿瘤治疗的单元。

    Light coupling adapter for photodynamic or photothermal therapy or photodynamic diagnosis and corresponding system
    3.
    发明公开
    Light coupling adapter for photodynamic or photothermal therapy or photodynamic diagnosis and corresponding system 有权
    系统光敏光电开关光电诊断系统

    公开(公告)号：EP2449994A1

    公开(公告)日：2012-05-09

    申请号：EP12151845.0

    申请日：2006-05-12

    申请人： SpectraCure AB

    发明人： Svanberg, Sune

    IPC分类号： A61B18/24 ,  A61M25/01 ,  A61M25/06 ,  A61M25/18 ,  A61N5/06 ,  A61N1/30

    CPC分类号： A61N5/0601 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  A61B2017/00057 ,  A61B2017/00477 ,  A61B2018/208 ,  A61B2018/2244 ,  A61B2562/228 ,  A61N5/062 ,  A61N2005/0612 ,  A61N2005/063 ,  A61N2005/067 ,  G02B6/3809

    摘要： A system configured for photodynamic or photothermal therapy and photodynamic diagnosis of a tissue is 5 disclosed. The system comprises in combination an assembly of: a proximal end adapter for a catheter comprising an adapter body (32), having proximal and distal ends, defining an axial lumen extending between the proximal and distal ends, a catheter mounting element at the distal end 10 of the adapter body (32) for sealingly mounting a catheter to the adapter body, and a hollow catheter (31), wherein the catheter mounting element connects a catheter body to the hollow catheter so that the hollow catheter extends from the distal end of the catheter body; a first light 15 guide (36) having proximal and distal ends, wherein said first light guide is sealingly contained in said axial lumen defining an axial optical path extending between the proximal and distal ends of the adapter body (32) towards said tissue (8) and into close proximity thereof or 20 interstitially into said tissue; an optical connector mounting element at the proximal end having mounted an optical connector (37) to the adapter body, and wherein said optical connector (37) is coupled o to a light source via a second light guide (38), such that light from said 25 light source is transmittable from said light source via said second light guide (38) and further via said optical connector (37) to said first light guide (36) via said proximal end adapter towards said tissue (8) through said catheter (31).

    摘要翻译： 公开了一种配置用于光动力学或光热疗法和组织光动力学诊断的系统。 该系统组合包括：用于导管的近端适配器，其包括适配器主体（32），其具有近端和远端，限定在近端和远端之间延伸的轴向腔，在远端处的导管安装元件 10，用于将导管密封地安装到适配器主体上的适配器主体（32）和中空导管（31），其中导管安装元件将导管主体连接到中空导管，使得中空导管从 导管体; 具有近端和远端的第一光15引导件（36），其中所述第一光导被密封地容纳在所述轴向内腔中，所述轴向内腔限定在适配器主体（32）的近端和远端之间朝向所述组织（8）延伸的轴向光路 ）并且紧密接近或20间隙地进入所述组织; 在近端处的光学连接器安装元件已经将光学连接器（37）安装到适配器主体，并且其中所述光学连接器（37）经由第二光导（38）耦合到光源，使得来自 所述25光源可通过所述第二光导（38）从所述光源透射，并且还经由所述光连接器（37）经由所述近端适配器通过所述导管（8）经由所述近端适配器朝所述组织（8）传递到所述第一光导（36） 31）。

    System for controlling and adjusting interstitial photodynamic light therapy parameters
    4.
    发明公开
    System for controlling and adjusting interstitial photodynamic light therapy parameters 有权
    系统on ung on n n n n n n n n n n n n n n n

    公开(公告)号：EP2431072A1

    公开(公告)日：2012-03-21

    申请号：EP11190657.4

    申请日：2007-08-15

    申请人： SpectraCure AB

    发明人： Svanberg, Sune ,  Andersson-Engels, Stefan ,  Johansson, Ann ,  Axelsson, Johan ,  Swartling, Johannes

    IPC分类号： A61N5/06 ,  A61B18/00 ,  A61B18/20 ,  A61B19/00

    CPC分类号： A61N5/062 ,  A61B2017/00022 ,  A61B2018/00642 ,  A61B2034/105 ,  A61N5/0601 ,  A61N2005/0612 ,  A61N2005/063

    摘要： A method and system for controlling and adjusting light in interstitial photodynamic light therapy (IPDT) in a subject is disclosed. More particularly, a method for controlling the light in interstitial tumor photodynamic light therapy is described using a calculation method for determination of status of tissue during the PDT treatment. The status is used in a feedback loop to control the continued PDT treatment. Methods are disclosed that constitute pre-treatment and realtime dosimetry modules for IPDT on the whole prostate glandular tissue. The method includes reconstruction of the target geometry, optimization of source fiber positions within this geometry, monitoring of the light attenuation during the treatment procedure and updating individual fiber irradiation times to take into account any variation in tissue light transmission. A control device that is arranged to restrict delivery of therapeutic light treatment at least temporary in dependence of at least one attribute of one of photodynamic treatment parameters. In comparison to no treatment feedback, a significant undertreatment of the patient as well as damage to healthy organs at risk are avoided.

    摘要翻译： 公开了一种用于控制和调节受试者中的间质性光动力光疗法（IPDT）中的光的方法和系统。 更具体地，使用用于在PDT处理期间确定组织状态的计算方法来描述用于控制间质肿瘤光动力光疗法中的光的方法。 该状态用于反馈回路以控制持续的PDT治疗。 公开了构成用于IPDT对整个前列腺腺组织的预处理和实时剂量测定模块的方法。 该方法包括重建目标几何形状，优化在该几何形状内的源光纤位置，监测处理过程中的光衰减和更新各个光纤照射时间以考虑到组织光透射中的任何变化。 一种控制装置，其被配置为根据光动力学治疗参数之一的至少一个属性至少临时地限制治疗性光处理的递送。 与没有治疗反馈相比，避免了对患者的重大治疗以及危及健康器官的损害。