公开(公告)号：EP3309166A2

公开(公告)日：2018-04-18

申请号：EP17175566.3

申请日：2014-01-23

申请人： Sphaera Pharma Pvt. Ltd.

发明人： Dugar, Sundeep ,  Schreiner, Frederic George ,  Mahajan, Dinesh ,  Sharma, Amit ,  Patil, Ishwar Rakesh ,  Kuila, Bilash

IPC分类号： C07J71/00 ,  C07J5/00 ,  C07J1/00 ,  C07J3/00 ,  C07J7/00 ,  C07J9/00 ,  C07J11/00 ,  C07J17/00 ,  C07J21/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  A61K31/56 ,  A61P21/00

CPC分类号： C07J17/00 ,  C07J1/0011 ,  C07J1/0022 ,  C07J3/005 ,  C07J5/0015 ,  C07J5/0053 ,  C07J7/0005 ,  C07J7/002 ,  C07J7/007 ,  C07J9/00 ,  C07J11/00 ,  C07J21/00 ,  C07J21/006 ,  C07J31/006 ,  C07J41/0011 ,  C07J41/0016 ,  C07J41/0038 ,  C07J41/005 ,  C07J43/003

摘要： The present invention provides novel compounds of 11β-hydroxy steroids and compositions and their application as pharmaceuticals for preventing or reversing injury to mitochondria, for treating or preventing diseases relating to mitochondrial dysfunction or depletion, and for inducing regeneration or restructuring of mitochondria as a means of treating diseases relating to abnormalities in mitochondrial structure and function in a human or animal subject. Also disclosed herein are methods for diagnosing injury to mitochondria and for diagnosing the success or failure of therapeutics designed to treat, prevent, or reverse injury to or depletion of mitochondria.

摘要翻译： 本发明提供了11β-羟基类固醇的新化合物及其组合物及其作为药物用于预防或逆转线粒体损伤，用于治疗或预防与线粒体功能障碍或耗竭有关的疾病，以及诱导线粒体再生或重建作为 治疗与人或动物受试者中线粒体结构和功能异常有关的疾病。 本文还公开了诊断线粒体损伤和诊断设计用于治疗，预防或逆转线粒体损伤或耗竭的治疗成功或失败的方法。

公开(公告)号：EP3309166A3

公开(公告)日：2018-08-22

申请号：EP17175566.3

申请日：2014-01-23

申请人： Sphaera Pharma Pvt. Ltd.

发明人： Dugar, Sundeep ,  Schreiner, Frederic George ,  Mahajan, Dinesh ,  Sharma, Amit ,  Patil, Ishwar Rakesh ,  Kuila, Bilash

IPC分类号： C07J71/00 ,  C07J5/00 ,  C07J1/00 ,  C07J3/00 ,  C07J7/00 ,  C07J9/00 ,  C07J11/00 ,  C07J17/00 ,  C07J21/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  A61K31/56 ,  A61P21/00

CPC分类号： C07J17/00 ,  C07J1/0011 ,  C07J1/0022 ,  C07J3/005 ,  C07J5/0015 ,  C07J5/0053 ,  C07J7/0005 ,  C07J7/002 ,  C07J7/007 ,  C07J9/00 ,  C07J11/00 ,  C07J21/00 ,  C07J21/006 ,  C07J31/006 ,  C07J41/0011 ,  C07J41/0016 ,  C07J41/0038 ,  C07J41/005 ,  C07J43/003

摘要： The present invention provides novel compounds of 11β-hydroxy steroids and compositions and their application as pharmaceuticals for preventing or reversing injury to mitochondria, for treating or preventing diseases relating to mitochondrial dysfunction or depletion, and for inducing regeneration or restructuring of mitochondria as a means of treating diseases relating to abnormalities in mitochondrial structure and function in a human or animal subject. Also disclosed herein are methods for diagnosing injury to mitochondria and for diagnosing the success or failure of therapeutics designed to treat, prevent, or reverse injury to or depletion of mitochondria.