公开(公告)号：EP3158333A1

公开(公告)日：2017-04-26

申请号：EP15730768.7

申请日：2015-06-19

申请人： Spinchip Diagnostics AS

发明人： BORCH, Stig Morten ,  HAMSUND, Torgeir ,  HOLTLUND, Jostein Geir ,  GULLIKSEN, Anja

IPC分类号： G01N33/543

CPC分类号： G01N1/10 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2400/0409 ,  B01L2400/0487 ,  B03D3/00 ,  G01N33/54313 ,  G01N33/54333 ,  G01N33/54366 ,  G01N2001/1006 ,  G01N2035/0449

摘要： The present invention provides a method of analyzing a sample containing an analyte to be qualitatively and/or quantitatively determined, comprising a binding step and a washing step, wherein the binding step comprises: interacting the analyte with beads having a density m1; obtaining a structure of packed beads comprising quantifiable bead complexes having a density m2; and the washing step comprises: dispersing the packed beads in a liquid medium having a density d>m2 and m1; and separating the liquid medium and the beads comprising the quantifiable bead complexes.

摘要翻译： 本发明提供了一种在流体芯片中转移珠子的方法，该流体芯片包括内部流体回路，其中至少一种反应物是珠粒的各种反应物可通过该内部流体回路通过使用离心力而移动，该方法包括以下步骤： 在所述流体回路的区段（7,15）中提供具有等于或小于ml的密度的珠（8），所述区段包括至少第一出口（16,13）; 向该部分提供第一液体介质，该液体介质具有密度d 2，使得d 2> ml; 并施加离心力使得珠子沿离心力的相反方向迁移。

公开(公告)号：EP3158332A1

公开(公告)日：2017-04-26

申请号：EP15730158.1

申请日：2015-06-19

申请人： Spinchip Diagnostics AS

发明人： BORCH, Stig Morten ,  HAMSUND, Torgeir ,  HOLTLUND, Jostein Geir ,  GULLIKSEN, Anja

IPC分类号： G01N33/543

CPC分类号： G01N1/10 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2400/0409 ,  B01L2400/0487 ,  B03D3/00 ,  G01N33/54313 ,  G01N33/54333 ,  G01N33/54366 ,  G01N2001/1006 ,  G01N2035/0449

摘要： The present invention provides a method of analyzing a sample containing an analyte to be qualitatively and/or quantitatively determined, comprising a binding step and a washing step, wherein the binding step comprises: interacting the analyte with beads having a density m1; obtaining a structure of packed beads comprising quantifiable bead complexes having a density m2; and the washing step comprises: dispersing the packed beads in a liquid medium having a density d>m2 and m1; and separating the liquid medium and the beads comprising the quantifiable bead complexes.

摘要翻译： 本发明提供了一种在流体芯片中转移珠子的方法，该流体芯片包括内部流体回路，其中至少一种反应物是珠粒的各种反应物可通过该内部流体回路通过使用离心力而移动，该方法包括以下步骤： 在所述流体回路的区段（7,15）中提供具有等于或小于ml的密度的珠（8），所述区段包括至少第一出口（16,13）; 向该部分提供第一液体介质，该液体介质具有密度d 2，使得d 2> ml; 并施加离心力使得珠子沿离心力的相反方向迁移。

公开(公告)号：EP3158334B1

公开(公告)日：2018-10-17

申请号：EP15735866.4

申请日：2015-06-19

申请人： Spinchip Diagnostics AS

发明人： BORCH, Stig Morten ,  HAMSUND, Torgeir ,  HOLTLUND, Jostein Geir ,  GULLIKSEN, Anja

IPC分类号： G01N33/543

CPC分类号： G01N1/10 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2400/0409 ,  B01L2400/0487 ,  B03D3/00 ,  G01N33/54313 ,  G01N33/54333 ,  G01N33/54366 ,  G01N2001/1006 ,  G01N2035/0449

摘要： The present invention provides a method of analyzing a sample containing an analyte to be qualitatively and/or quantitatively determined, comprising a binding step and a washing step, wherein the binding step comprises: interacting the analyte with beads having a density m1; obtaining a structure of packed beads comprising quantifiable bead complexes having a density m2; and the washing step comprises: dispersing the packed beads in a liquid medium having a density d>m2 and m1; and separating the liquid medium and the beads comprising the quantifiable bead complexes.

公开(公告)号：EP3158333B1

公开(公告)日：2017-12-27

申请号：EP15730768.7

申请日：2015-06-19

申请人： Spinchip Diagnostics AS

发明人： BORCH, Stig Morten ,  HAMSUND, Torgeir ,  HOLTLUND, Jostein Geir ,  GULLIKSEN, Anja

IPC分类号： G01N33/543

CPC分类号： G01N1/10 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2400/0409 ,  B01L2400/0487 ,  B03D3/00 ,  G01N33/54313 ,  G01N33/54333 ,  G01N33/54366 ,  G01N2001/1006 ,  G01N2035/0449

摘要： The present invention provides a method of analyzing a sample containing an analyte to be qualitatively and/or quantitatively determined, comprising a binding step and a washing step, wherein the binding step comprises: interacting the analyte with beads having a density m1; obtaining a structure of packed beads comprising quantifiable bead complexes having a density m2; and the washing step comprises: dispersing the packed beads in a liquid medium having a density d>m2 and m1; and separating the liquid medium and the beads comprising the quantifiable bead complexes.

公开(公告)号：EP3158334A1

公开(公告)日：2017-04-26

申请号：EP15735866.4

申请日：2015-06-19

申请人： Spinchip Diagnostics AS

发明人： BORCH, Stig Morten ,  HAMSUND, Torgeir ,  HOLTLUND, Jostein Geir ,  GULLIKSEN, Anja

IPC分类号： G01N33/543

CPC分类号： G01N1/10 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2400/0409 ,  B01L2400/0487 ,  B03D3/00 ,  G01N33/54313 ,  G01N33/54333 ,  G01N33/54366 ,  G01N2001/1006 ,  G01N2035/0449

摘要： The present invention provides a method of analyzing a sample containing an analyte to be qualitatively and/or quantitatively determined, comprising a binding step and a washing step, wherein the binding step comprises: interacting the analyte with beads having a density m1; obtaining a structure of packed beads comprising quantifiable bead complexes having a density m2; and the washing step comprises: dispersing the packed beads in a liquid medium having a density d>m2 and m1; and separating the liquid medium and the beads comprising the quantifiable bead complexes.

摘要翻译： 本发明提供了一种在流体芯片中转移珠子的方法，该流体芯片包括内部流体回路，其中至少一种反应物是珠粒的各种反应物可通过该内部流体回路通过使用离心力而移动，该方法包括以下步骤： 在所述流体回路的区段（7,15）中提供具有等于或小于ml的密度的珠（8），所述区段包括至少第一出口（16,13）; 向该部分提供第一液体介质，该液体介质具有密度d 2，使得d 2> ml; 并施加离心力使得珠子沿离心力的相反方向迁移。