公开(公告)号：EP2552406B1

公开(公告)日：2018-01-24

申请号：EP11722599.5

申请日：2011-03-26

申请人： Stemmatters, Biotecnologia e Medicina Regenerativa, S.A.

发明人： DA SILVA CORREIA, Joana Catarina ,  ANTUNES DE OLIVEIRA, Joaquim Miguel ,  TEIXEIRA DE OLIVEIRA, João Manuel ,  AMANDI ROMERO DE SOUSA, Rui Pedro ,  Gonçalves dos Reis, Rui Luis

IPC分类号： A61K9/00 ,  A61K47/36 ,  A61L24/00 ,  A61L27/34

CPC分类号： C08B37/006 ,  A61L27/28 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/64 ,  A61L2400/06 ,  C08L5/00

摘要： This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. Formulations of gellan gum with different degrees of acylation serve as precursor material for insertion of a polymerizable moiety. The materials are capable of free radical polymerization with a photo-initiator at mild temperatures and exposure to ultraviolet light, enabling control of reticulation and withstanding the encapsulation of human and animal cells and/or drugs, and any combination thereof. The physicochemical and biological properties can be adjusted by combining different formulations of gellan gum and reaction conditions. The matrix can be used either as an acellular or cellular system, dispensed manually or automatically by injection and crosslinked directly at the site of application, and can be processed using manual or automated systems in different types of scaffolds, such as hydrogels, fibers, 3D structures and micro- or nanoparticles.