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公开(公告)号：EP3183266B1
公开(公告)日：2019-05-29
申请号：EP15787045.2
申请日：2015-08-20
IPC分类号： C07K16/18 , C12N15/13 , A61K39/395
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2.发明公开DIAGNOSTIC METHODS INVOLVING DETERMINING GENE COPY NUMBERS AND SNPs IN THE Fc RII/Fc RIII GENE CLUSTER, AND PROBES FOR USE IN SUCH METHODS TO DETECT SUSCEPTIBILITY TO AND TREATMENT EFFICACY IN AUTOIMMUNE DISEASES 有权随着对发现是否易在AUTOIMUUNKRANKHEITEN按Fc RII RIII FC基因簇中这样的方法基因拷贝数和SNP和使用探针的测定及疗效DIAGNOSTICHE过程
公开(公告)号：EP1989323A2
公开(公告)日：2008-11-12
申请号：EP06835684.9
申请日：2006-12-22
发明人： ROOS, Dirk , KUIJPERS, Taco Willem
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The invention relates to diagnostic methods to predict whether a subject is predisposed for acquiring a disease or to predict the therapy responsiveness of an individual patient. Provided is a method for determining whether a subject is predisposed for developing an autoimmune disease, comprising determining in a sample isolated from said subject the amount of intact genes, or gene products thereof, of the FcϜRII/FcϜRIII gene cluster, said gene cluster comprising the FCGR2C, FCGR3A, FCGR2A and FCGR3B genes encoding an activating FcϜR, and FCGR2B encoding an inhibitory FcϜ R; and correlating said amount to the amount observed in a healthy population. Also provided is a method to predict the responsiveness of a subject to therapy with intravenous immunoglobulin (IVIg) therapy or a monospecific biological, such as a humanized or human monoclonal antibody or a chimeric molecule, comprising the C-terminal Fc-tail of IgG.
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公开(公告)号：EP3183266A1
公开(公告)日：2017-06-28
申请号：EP15787045.2
申请日：2015-08-20
IPC分类号： C07K16/18 , C12N15/13 , A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , C07K16/36 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76
摘要： The invention relates to isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H. The invention further relates to the use of such antibodies and fragments for inhibiting complement activation and treatment of disorders associated with complement activation.
摘要翻译： 本发明涉及对因子H特异的分离的，合成的或重组的抗体及其片段。本发明进一步涉及这种抗体和片段用于抑制补体激活和治疗与补体活化有关的病症的用途。
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公开(公告)号：EP2356253A1
公开(公告)日：2011-08-17
申请号：EP09756361.3
申请日：2009-11-05
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C07H21/04 , C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2533/107 , C12Q2537/143 , C12Q2525/155 , C12Q2531/113
摘要： The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid.
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5.发明授权DIAGNOSTIC METHODS INVOLVING DETERMINING GENE COPY NUMBERS AND SNPs IN THE Fc RII/Fc RIII GENE CLUSTER, AND PROBES FOR USE IN SUCH METHODS TO DETECT SUSCEPTIBILITY TO AND TREATMENT EFFICACY IN AUTOIMMUNE DISEASES 有权随着对发现是否易在AUTOIMUUNKRANKHEITEN按Fc RII RIII FC基因簇中这样的方法基因拷贝数和SNP和使用探针的测定及疗效DIAGNOSTICHE过程
公开(公告)号：EP1989323B1
公开(公告)日：2011-07-06
申请号：EP06835684.9
申请日：2006-12-22
发明人： ROOS, Dirk , KUIJPERS, Taco Willem
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The invention relates to diagnostic methods to predict whether a subject is predisposed for acquiring a disease or to predict the therapy responsiveness of an individual patient. Provided is a method for determining whether a subject is predisposed for developing an autoimmune disease, comprising determining in a sample isolated from said subject the amount of intact genes, or gene products thereof, of the FcϜRII/FcϜRIII gene cluster, said gene cluster comprising the FCGR2C, FCGR3A, FCGR2A and FCGR3B genes encoding an activating FcϜR, and FCGR2B encoding an inhibitory FcϜ R; and correlating said amount to the amount observed in a healthy population. Also provided is a method to predict the responsiveness of a subject to therapy with intravenous immunoglobulin (IVIg) therapy or a monospecific biological, such as a humanized or human monoclonal antibody or a chimeric molecule, comprising the C-terminal Fc-tail of IgG.
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公开(公告)号：EP3999073A1
公开(公告)日：2022-05-25
申请号：EP20840846.8
申请日：2020-07-17
发明人： LAUDER, Scott , PURCELL, Tom , GOVINDARAJAN, Sridhar , KUIJPERS, Taco Willem , WOUTERS, Diana , BROUWER, Maria Clara , POUW, Richard Benjamin , RISPENS, Taede , JONGERIUS, Ilse , DEKKERS, Gillian
IPC分类号： A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/395 , C07K16/18 , C07K16/36
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