利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.011 秒)

    METHODS AND MEANS FOR DETECTING CELLS USING SURFACE PLASMON RESONANCE
    2.
    发明公开
    METHODS AND MEANS FOR DETECTING CELLS USING SURFACE PLASMON RESONANCE 审中-公开
    VERFAHREN ZUR ERKENNUNG VON ZELLEN MITOBERFLÄCHENPLASMONRESONANZ

    公开(公告)号：EP2936122A1

    公开(公告)日：2015-10-28

    申请号：EP13818504.6

    申请日：2013-12-19

    申请人： Stichting Sanquin Bloedvoorziening ,  Ibis Technologies BV

    发明人： VIDARSSON, Gestur ,  SCHASFOORT, Richard, Bernardus, Maria

    IPC分类号： G01N21/55 ,  G01N33/80

    CPC分类号： G01N33/80 ,  G01N21/553 ,  G01N33/54373 ,  G01N2333/705

    摘要： The invention relates to means and methods for detecting a cell surface molecule in a cell sample. The invention further relates to a method for blood group typing and screening and to SPR sensors and SPR measuring systems suitable for use in such methods. The method includes steps of allowing a liquid cell sample to flow to and along the sensor surface, temporarily reducing the shear rate of the liquid sample to allow cells in the sample to sediment by binding to a binding compound immobilised on a metal film on the sensor surface, and removing unbound cells or non-specifically bound cells or fragments thereof. Moreover, the ratio of the magnitude of the specific total signal response to the signal response during sedimentation is determined.

    摘要翻译： 本发明涉及用于检测细胞样品中的细胞表面分子的方法和方法。 本发明还涉及用于血型分型和筛选的方法以及适用于这种方法的SPR传感器和SPR测量系统。 该方法包括允许液体细胞样品流过并沿着传感器表面的步骤，暂时降低液体样品的剪切速率，以允许样品中的细胞通过结合固定在传感器上的金属膜上的结合化合物而沉淀 去除未结合的细胞或非特异性结合的细胞或其片段。 此外，确定特定总信号响应的大小与沉降期间的信号响应的比率。

    METHODS FOR INCREASING THE THERAPEUTIC EFFICACY OF IMMUNOGLOBULIN G CLASS 3 (IGG3) ANTIBODIES
    3.
    发明公开
    METHODS FOR INCREASING THE THERAPEUTIC EFFICACY OF IMMUNOGLOBULIN G CLASS 3 (IGG3) ANTIBODIES 有权
    方法，提高免疫球蛋白G CLASS-3（IgG3）的抗体的治疗功效

    公开(公告)号：EP2229409A1

    公开(公告)日：2010-09-22

    申请号：EP08707123.9

    申请日：2008-01-18

    申请人： Stichting Sanquin Bloedvoorziening

    发明人： VIDARSSON, Gestur ,  VAN DER SCHOOT, Catherine, Elisabeth

    IPC分类号： C07K16/00 ,  C12N15/01

    CPC分类号： C07K16/00

    摘要： The present invention relates to methods for increasing the therapeutic efficacy of immunoglobulin G class 3 (IgG3) antibodies, immunoglobulin G class 3 (IgG3) antibodies with an improved therapeutic efficacy and the use thereof as a medicament, in particularly a medicament for immunotherapy. Specifically, the present invention relates to methods for increasing the therapeutic efficacy of an immunoglobulin G class 3 (IgG3) antibody comprising providing a mutated immunoglobulin G class 3 (IgG3) antibody, wherein the mutation, as compared to the parent immunoglobulin G class 3 (IgG3) antibody, comprises a replacement of the amino acid arginine (R) at position 435 in the CH3 domain with the amino acid histidine (H), and antibodies obtained by the present methods and their use as a medicament.