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    ALIGNMENT-TOLERANT PHOTONIC SENSING SYSTEM
    4.
    发明公开
    ALIGNMENT-TOLERANT PHOTONIC SENSING SYSTEM 审中-公开

    公开(公告)号：EP4390375A1

    公开(公告)日：2024-06-26

    申请号：EP22215684.6

    申请日：2022-12-21

    Applicant: Imec VZW

    Inventor： JANSEN, Roelof ,  SONG, Jeonghwan

    IPC: G01N21/552 ,  G01N21/64 ,  G01N21/77 ,  B01L3/00 ,  G01N21/65

    CPC classification number: G01N21/648 ,  G01N21/6452 ,  G01N21/65 ,  G01N21/6454 ,  G01N21/7703 ,  G01N21/553

    Abstract: A sensing system (100) comprising an illumination module (108), a cartridge (102) with photonic sensor chip (110; 200; 300), and a cartridge holder (104) for locking the cartridge into a sensing position. The photonic sensor chip comprises a plurality of grating couplers (202; 302) in a first areal portion (303) and a plurality of sensing sites (204), and is aligned relative to the illumination module up to permitted alignment tolerances when the cartridge is locked into the sensing position. A permitted amount of longitudinal misalignment (δx) and lateral misalignment (δy) define a peripheral portion (304) of the photonic sensor chip, surrounding the first areal portion. The illumination module is arranged to illuminate a second areal portion (301) of the photonic sensor chip, when the sensor cartridge is locked into the sensing position. The second areal portion fully includes the first areal portion and at least partially includes the peripheral portion.

    METHODS FOR PREPARING A DILUTION SERIES
    5.
    发明公开
    METHODS FOR PREPARING A DILUTION SERIES 审中-公开

    公开(公告)号：EP3382368A1

    公开(公告)日：2018-10-03

    申请号：EP18163599.6

    申请日：2018-03-23

    Applicant: GE Healthcare Bio-Sciences AB

    Inventor： JOHANSSON, Johan ,  DALMO, Tomas

    IPC: G01N1/38 ,  G01N21/27 ,  G01N21/552 ,  G01N33/543 ,  G01N35/00

    CPC classification number: G01N33/54373 ,  G01N1/38 ,  G01N21/553 ,  G01N33/531 ,  G01N33/54393 ,  G01N2001/383 ,  G01N2035/00702 ,  G01N2201/12746

    Abstract: The present invention relates to a first embodiment of a method for preparing a dilution series, comprising the steps
    a. providing a first sample having a first concentration of a substance and a second sample having a second concentration of said substance,
    b. injecting a quantity of the second sample to the measuring device and registering at least one response from a measurement,
    c. altering the concentration of the second sample by adding an amount of the first sample to the second sample,
    d. injecting a quantity of the second sample generated in step c to the measuring device and registering at least one response from a measurement,
    e. repeating steps d) and e) until a predetermined number of responses have been registered, said predetermined number of responses being at least three, preferably at least four, more preferably at least eight.
    The invention also comprises a second embodiment of the method for preparing a dilution series and to a biosensor system arranged to perform the steps of the first or second method.

    A METHOD FOR DETERMINING INSTRUMENT-DEPENDING PARAMETERS OF A SURFACE PLASMON RESONANCE BIOSENSOR SYSTEM
    8.
    发明公开
    A METHOD FOR DETERMINING INSTRUMENT-DEPENDING PARAMETERS OF A SURFACE PLASMON RESONANCE BIOSENSOR SYSTEM 审中-公开

    公开(公告)号：EP3362779A1

    公开(公告)日：2018-08-22

    申请号：EP16779154.0

    申请日：2016-10-12

    Applicant: GE Healthcare Bio-Sciences AB

    Inventor： POL, Ewa

    IPC: G01N21/27 ,  G01N21/552 ,  G01N33/53 ,  G12B13/00

    CPC classification number: G01N21/553 ,  G01N21/274 ,  G01N33/6803 ,  G01N2201/127

    Abstract: A method for determining instrument depending parameters of a surface plasmon resonance (SPR) biosensor system comprising the steps of:a) identifying (S1) an analyte for use in a calibration step, said analyte having known molecular weight, known diffusion constant, known refractive index increment and a known concentration; b) measuring active concentration (S3) of the analyte by the use of the SPR biosensor system according to a known method, preferably according to calibration-free concentration analysis, using the analyte identified in step a) and a chip to which the analyte can bind, said known method including the use of an instrument depending constant that is not adopted for each specific instrument, chip and flow cell combination; c) comparing (S5) the known concentration of the analyte with the active concentration retrieved in step b); and d) adjusting (S7) the instrument depending constant used in the known method for measuring active concentration according to a result of the comparing in step c).

    APPARATUS AND METHOD FOR OPTICALLY DETECTING ANALYTES
    9.
    发明授权
    APPARATUS AND METHOD FOR OPTICALLY DETECTING ANALYTES 有权

    公开(公告)号：EP2630468B1

    公开(公告)日：2018-07-11

    申请号：EP11833912.6

    申请日：2011-08-08

    Applicant: Nokia Technologies Oy

    Inventor： NISKANEN, Antti ,  KIVIOJA, Jani

    IPC: G01N21/17 ,  G01N27/00 ,  G01N33/50 ,  H01L31/0232 ,  G02B5/00 ,  G01N21/25 ,  G01N21/552 ,  G01N21/64 ,  G01N33/543

    CPC classification number: G01N21/554 ,  G01N21/253 ,  G01N21/255 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/6452

    Abstract: An apparatus comprising a processor and memory including computer program code. The memory and computer program code can be configured to, with the processor, cause the apparatus to illuminate one or more sensor elements with electromagnetic radiation emitted from corresponding regions of an electronic display. The one or more sensor elements can be configured to exhibit a specific electrical response to the illumination when a specific set of analytes are bound to the one or more sensor elements, determine the electrical response of the one or more sensor elements, and compare the determined electrical response with one or more predetermined electrical responses to determine a match. Each predetermined electrical response can be associated with the binding of a different set of analytes, wherein determination of a match allows the specific set of analytes bound to the one or more sensor elements to be identified.

    METHOD TO SCREEN HIGH AFFINITY ANTIBODY
    10.
    发明授权
    METHOD TO SCREEN HIGH AFFINITY ANTIBODY 有权

    公开(公告)号：EP2685238B1

    公开(公告)日：2018-06-13

    申请号：EP13188272.2

    申请日：2009-08-25

    Applicant: F. Hoffmann-La Roche AG

    Inventor： Schraeml, Michael ,  Von Proff, Leopold

    IPC: G01N21/55 ,  C07K16/26 ,  G01N21/552 ,  G01N33/68

    CPC classification number: G01N33/6854 ,  C07K16/26 ,  G01N21/553

    Abstract: The current invention reports a method for producing an antibody comprising the steps of a) providing a plurality of hybridoma cells each expressing an antibody, b) determining the time dependent amount of said antibody bound to the respective antigen by surface plasmon resonance at different temperatures and different antibody concentrations, c) calculating with the time dependent amount determined in b) based on equations (II) to (XIII) at least the thermodynamic parameters (i) standard association binding entropy (”S°€¡ass), (ii) standard dissociation binding entropy (”S°€¡diss), (iii) standard binding entropy (”S°), (iv) free standard binding enthalpy (”G°), (v) standard dissociation free binding enthalpy (”G°€¡diss), (vi) standard association free binding enthalpy (”S°€¡ass), (vii) -T”S°, (viii) dissociation rate constant k d , (ix) equilibrium binding constant K D , and (x) association rate constant k a , d) selecting a hybridoma cell producing an antibody with at least two of the following: i) a standard association binding entropy of less than 10 J/K*mol, ii) an absolute standard dissociation binding entropy of 100 J/mol*K or more, iii) an absolute standard binding entropy of 100 J/mol*K or more, e) producing an antibody by cultivating said selected cell under conditions suitable for the expression of said antibody and recovering said antibody from the cells or/and the cultivation medium

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