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1.发明公开Apparatus for delivering antibiotic powders into the femoral canal 有权GerätzumEinführenantibiotischer Pulver in den Femurmarkkanal
公开(公告)号：EP0958789A2
公开(公告)日：1999-11-24
申请号：EP99109800.5
申请日：1999-05-19
CPC分类号： A61L31/16 , A61B17/88 , A61L31/06 , A61L2300/406 , A61L2300/602 , A61L2300/62 , A61M2025/0057 , A61M2202/064 , A61M2210/02 , C08L67/04
摘要： Apparatus of the present invention include encapsulating the antibiotic in fine particles of bioabsorbable polymer which will yield a constant dissolution of the antibiotic over a predefined dosing period (such as a 7-10 day period), with residual antibiotic being thereafter delivered only until the bioabsorable polymer is resorbed; and delivering the fine particle powder to the surgical site as an aerosol spray. It is preferable that the antibiotic and the polymer be thermostable so that the exothermic reaction of bone cement does not degrade the polymer or the antibiotic. A suitable antibiotic for this purpose is an aminoglycoside. One apparatus according to the invention includes a porous delivery tube which is dimensioned to fit comfortable in a bone canal and which is coupled to a aerosol canister containing the antibiotic powder of the invention. Another apparatus according to the invention includes a porous delivery tube which is preloaded with measured amounts of antibiotic powder and which is adapted to be coupled to a source of compressed air.
摘要翻译： 本发明的装置包括将抗生素包封在生物可吸收聚合物的细颗粒中，其将在预定的给药期（例如7-10天期）内产生抗生素的不断溶解，然后将残留的抗生素直接递送至生物可吸收的 聚合物被吸收; 并将细颗粒粉末作为气溶胶喷雾递送到外科手术部位。 优选地，抗生素和聚合物是耐热的，使得骨水泥的放热反应不会降解聚合物或抗生素。 用于此目的的合适的抗生素是氨基糖苷类。 根据本发明的一种装置包括多孔输送管，该多孔输送管的尺寸被设计成适合于在骨管中舒适，并且与多个包含本发明的抗生素粉末的气溶胶罐相连。 根据本发明的另一种装置包括多孔输送管，其预先装有测量量的抗生素粉末，并适于与压缩空气源连接。
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公开(公告)号：EP0958789A3
公开(公告)日：2000-12-27
申请号：EP99109800.5
申请日：1999-05-19
CPC分类号： A61L31/16 , A61B17/88 , A61L31/06 , A61L2300/406 , A61L2300/602 , A61L2300/62 , A61M2025/0057 , A61M2202/064 , A61M2210/02 , C08L67/04
摘要： Apparatus of the present invention include encapsulating the antibiotic in fine particles of bioabsorbable polymer which will yield a constant dissolution of the antibiotic over a predefined dosing period (such as a 7-10 day period), with residual antibiotic being thereafter delivered only until the bioabsorable polymer is resorbed; and delivering the fine particle powder to the surgical site as an aerosol spray. It is preferable that the antibiotic and the polymer be thermostable so that the exothermic reaction of bone cement does not degrade the polymer or the antibiotic. A suitable antibiotic for this purpose is an aminoglycoside. One apparatus according to the invention includes a porous delivery tube which is dimensioned to fit comfortable in a bone canal and which is coupled to a aerosol canister containing the antibiotic powder of the invention. Another apparatus according to the invention includes a porous delivery tube which is preloaded with measured amounts of antibiotic powder and which is adapted to be coupled to a source of compressed air.
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