公开(公告)号：EP2968662B1

公开(公告)日：2018-11-21

申请号：EP13878044.0

申请日：2013-07-22

申请人： Board of Trustees of the University of Arkansas

发明人： BIRIS, Alexandru, S.

IPC分类号： A61L27/14 ,  A61L27/58 ,  A61L27/02 ,  A61F2/28

CPC分类号： A61L27/54 ,  A61F2/28 ,  A61F2002/30224 ,  A61F2002/30971 ,  A61L27/34 ,  A61L27/446 ,  A61L27/46 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2420/04 ,  A61L2420/08 ,  A61L2430/02 ,  A61L2430/12 ,  Y10T156/1075

摘要： A method for producing a polymer film includes: obtaining a load graph representing a functional relationship between a weight percentage of tissue forming nanoparticles in a polymer film and a maximum load of that polymer film; obtaining a stress graph representing a functional relationship between the weight percentage of tissue forming nanoparticles in a polymer film and maximum stress of that polymer film; determining a first weight percentage corresponding to a peak of the load graph and determining a second weight percentage corresponding to a peak of the stress graph; determining an optimal weight percentage based on the first and second weight percentage values; and producing a polymer film having tissue forming nanoparticles at the optimal weight percentage.

公开(公告)号：EP3209343B1

公开(公告)日：2018-09-05

申请号：EP15784035.6

申请日：2015-10-21

申请人： BIOTRONIK SE & Co. KG ,  Albert-Ludwigs-Universität Freiburg

发明人： BUNGE, Andreas ,  BERGMANN,Michael ,  LEDERNEZ, Loic ,  HORAK, Josef ,  URBAN, Gerald

IPC分类号： A61L27/28 ,  A61L27/50 ,  A61L27/34 ,  A61L27/44 ,  A61L31/10 ,  A61L31/12 ,  A61L31/14

CPC分类号： A61L27/44 ,  A61L27/303 ,  A61L27/34 ,  A61L27/3616 ,  A61L27/446 ,  A61L27/505 ,  A61L27/507 ,  A61L27/54 ,  A61L27/56 ,  A61L31/10 ,  A61L31/125 ,  A61L31/128 ,  A61L31/143 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/406 ,  A61L2300/606 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2420/02

摘要： A method for treating a medical implant uses plasma polymerization to apply a coating At least one treatment parameter is selected so that the reactive chemical groups of the coating are chemically modified to prevent an adsorption of interfering substances into the coating. An implant includes a plasma polymer coating that is biocompatible, and includes a antibiotically acting metal. The coating is free from aldehyde groups

公开(公告)号：EP2939695B1

公开(公告)日：2018-08-29

申请号：EP15163241.1

申请日：2005-05-13

申请人： Interface Biologics, Inc

发明人： Santerre, Paul J ,  LaRonde, Frank J ,  Li, Mei

IPC分类号： A61K47/50 ,  A61L27/54 ,  C08G18/73 ,  C08G18/42

CPC分类号： A61K47/56 ,  A61K9/0024 ,  A61K47/55 ,  A61K47/59 ,  A61K47/60 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/45 ,  A61L2300/604 ,  C08G18/4277 ,  C08G18/73

摘要： A biological coupling agent of the general formula (III) PBio-LINK A-PBio (III) wherein PBio is a fluoroquinolone linked to LINK A through a hydrolysable covalent bond and having at least one functional group to permit step growth polymerization; and LINK A is a coupled central flexible linear first segment of

公开(公告)号：EP3357518A1

公开(公告)日：2018-08-08

申请号：EP18153729.1

申请日：2012-10-03

申请人： Hyalex Orthopaedics, Inc.

发明人： KOURTIS, Lampros ,  MYUNG, David ,  CHANG, Daniel ,  SUN, Timothy ,  YU, Bing ,  JAASMA, Michael J. ,  HARTDEGEN, Vernon

IPC分类号： A61L24/04 ,  A61L24/00 ,  C09J175/06 ,  C09J4/06 ,  C08G18/48 ,  C08G18/65 ,  C08G18/67 ,  C08G18/32 ,  A61L27/26 ,  C09J133/14

CPC分类号： C08G18/6229 ,  A61B17/56 ,  A61F2/30 ,  A61K47/32 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/043 ,  A61L24/06 ,  A61L2300/406 ,  A61L2430/24 ,  A61M5/19 ,  B65D85/70 ,  C08G18/3206 ,  C08G18/4854 ,  C08G18/6511 ,  C08G18/6705 ,  C08G18/728 ,  C08G81/024 ,  C08L33/08 ,  C08L33/12 ,  C09J4/06 ,  C09J133/14 ,  C09J135/02 ,  C08F2220/343 ,  C08F220/14

摘要： A device comprises:
an orthopedic joint implant comprising a polyurethane IPN or polyurethane semi-IPN; and
a urethane dimethacrylate-methyl methacrylate copolymer attached to the polyurethane IPN or polyurethane semi-IPN, the urethane dimethacrylate-methyl methacrylate copolymer comprising a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate, wherein the plurality of first polymer regions based on urethane dimethacrylate comprises a plurality of hard segments and soft segments.

公开(公告)号：EP3185905A4

公开(公告)日：2018-04-04

申请号：EP15829615

申请日：2015-08-05

申请人： THE UNIV OF MEMPHIS

发明人： BOWLIN GARY LEE ,  RODRIGUEZ ISAAC ANTHONY ,  BURGER BRENTON WALTER

IPC分类号： A61K47/42 ,  A61K9/70 ,  A61K35/644 ,  A61K47/36 ,  A61L27/18 ,  A61L27/24 ,  A61L27/46 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  A61P17/00 ,  A61P19/00

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/222 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3604 ,  A61L27/365 ,  A61L27/46 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/412 ,  A61L2430/02 ,  C08L67/04 ,  C08L89/06

摘要： The invention features biodegradable materials, and in vitro and in vivo methods of using such compositions to promote bone and soft tissue growth and healing.

公开(公告)号：EP3285817A1

公开(公告)日：2018-02-28

申请号：EP16722521

申请日：2016-04-11

申请人： USTAV MAKROMOLEKULARNI CHEMIE AV CR V V I

发明人： KRULIS ZDENEK ,  SLOUF MIROSLAV ,  BENES HYNEK ,  KOVAROVA JANA ,  MICHALKOVA DANUSE ,  NEVORALOVA MARTINA

IPC分类号： A61L27/16 ,  A61L27/50 ,  A61L27/54 ,  C08K5/00 ,  C08L23/06

CPC分类号： A61L27/16 ,  A61L27/50 ,  A61L27/505 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/428 ,  C08K5/005 ,  C08K5/0058 ,  C08K5/1545 ,  C08K5/20 ,  C08K5/40 ,  C08L23/06 ,  C08L23/04

摘要： The present invention provides a composition for stabilization of polyethylene, consisting of a first component selected from the group comprising tocoferols, tocotrienols and 5 mixtures thereof, and of a second component which is a tetracycline antibiotic. Furthermore, the invention provides polyethylene comprising this mixture, preferably in an amount of at least 200 ppm, methods of production thereof, and implants for human or veterinary medicine comprising said stabilized polyethylene.

公开(公告)号：EP3242677A1

公开(公告)日：2017-11-15

申请号：EP16735324.2

申请日：2016-01-05

申请人： CardioVascular BioTherapeutics, Inc.

发明人： GARDNER, Vance ,  THOMAS, Kenneth ,  JACOBS, John ,  FLAA, Mickael

IPC分类号： A61K38/16 ,  A61P17/02

CPC分类号： A61K38/1825 ,  A61K9/0014 ,  A61K9/0024 ,  A61K45/06 ,  A61L15/44 ,  A61L26/0066 ,  A61L27/54 ,  A61L27/60 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414

摘要： Methods for detecting, imaging, analyzing, diagnosing and/or treating cutaneous conditions and dermatoses such as disorders of the skin, subcutaneous tissues, mucous membranes, poorly vascularized tissues and/or other tissue disorders, including erosions, fissures, transient and/or chronic sores, burns, wounds, ulcers, lesions and infections. In particular embodiments, treatments include methods for improving skin and related tissue healing and repair, offloading of damaged tissues and/or increasing angiogenesis in response to specifically diagnosed conditions.

公开(公告)号：EP2249892B1

公开(公告)日：2017-11-15

申请号：EP09719739.6

申请日：2009-02-20

申请人： Hexacath

发明人： ASCHER, Gilles ,  CAMENZIND, Edoardo

IPC分类号： A61L31/10 ,  A61L31/16

CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/622 ,  C08L71/02 ,  C08L39/06

公开(公告)号：EP3134482A4

公开(公告)日：2017-11-08

申请号：EP15782551

申请日：2015-04-22

申请人： AGILE BIOMEDICAL INC

发明人： JENNINGS LISA K ,  MCCANLESS JONATHAN D ,  CHEN XIAOPING ,  COLE MICHAEL

IPC分类号： C09D133/04 ,  C08F222/10 ,  C09D4/00 ,  C09D7/12

CPC分类号： A61L31/10 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/204 ,  A61L2300/406 ,  A61L2300/606 ,  A61L2420/02 ,  A61L2420/06 ,  C08F222/10 ,  C08F2222/102 ,  C09D4/00 ,  C08F228/00

摘要： Polymeric coatings, their applications, and the methods of their preparation are described. The coatings may be used to confer desirable properties to the consumer and/or medical products. Also described are methods of loading therapeutic agents on the polymeric coatings and the applications of the drug eluting polymeric coatings thus obtained.

公开(公告)号：EP1488816B1

公开(公告)日：2017-10-04

申请号：EP03707196.6

申请日：2003-03-04

申请人： Next 21 K.K.

发明人： SUZUKI, Shigeki

IPC分类号： A61L27/38 ,  C12N5/00 ,  A61L27/54 ,  A61L27/58 ,  A61L27/60 ,  A61L31/14 ,  A61F13/00 ,  A61M25/10 ,  A61M37/00

CPC分类号： A61M37/00 ,  A61F13/00063 ,  A61F13/00068 ,  A61F2013/00174 ,  A61F2013/00221 ,  A61F2013/00536 ,  A61F2013/0054 ,  A61F2013/00927 ,  A61L27/3804 ,  A61L27/3895 ,  A61L27/54 ,  A61L27/58 ,  A61L27/60 ,  A61L31/148 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/414 ,  A61M25/10