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公开(公告)号：EP1679371B1
公开(公告)日：2012-09-12
申请号：EP04773361.3
申请日：2004-09-15
申请人： Sumitomo Chemical Company, Limited , JAPAN as represented by PRESIDENT OF NATIONAL CANCER CENTER
CPC分类号： G01N33/5011 , C12Q1/6827 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2523/125
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公开(公告)号：EP1679371A1
公开(公告)日：2006-07-12
申请号：EP04773361.3
申请日：2004-09-15
申请人： Sumitomo Chemical Company, Limited , JAPAN as represented by PRESIDENT OF NATIONAL CANCER CENTER
IPC分类号： C12N15/09 , C12Q1/68 , C12Q1/02 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , G01N33/15 , G01N33/50
CPC分类号： G01N33/5011 , C12Q1/6827 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2523/125
摘要： The present invention relates to a method for assessing a cancerous state of a mammal-derived specimen, which comprises:
(1) a first step of measuring a methylation frequency of Neurofilament3 gene contained in a mammal-derived specimen or an index value having the correlation therewith, and
(2) a second step of determining a cancerous state of the specimen based on a difference obtained by comparing the measured methylation frequency or the index value having the correlation therewith, with a control; and the like.摘要翻译： 本发明涉及哺乳动物来源的标本的癌症状态的评估方法，其包括：（1）测定来自哺乳动物的标本中的神经丝3基因的甲基化频率或具有相关性的指标值的第一步骤 （2）基于将测定的甲基化频率或与其具有相关性的指标值进行比较而得到的差异与对照进行判定的第2工序， 等等。
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公开(公告)号：EP1679370B1
公开(公告)日：2009-12-09
申请号：EP04773354.8
申请日：2004-09-15
IPC分类号： C12N15/09 , C12Q1/68 , C12Q1/02 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , G01N33/15 , G01N33/50
CPC分类号： G01N33/57496 , C12Q1/6827 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2523/125
摘要： A method of evaluating the degree of cancerization of a specimen originating in a mammal characterized by comprising: (1) the first step of measuring the methylation frequency or an indication correlating thereto in Fibrillin 2 gene contained in the mammal-origin specimen; and (2) the second step of judging the degree of cancerization of the above-described specimen based on the difference obtained by comparing the methylation frequency or the indication correlating thereto having been measured above with the data of a control; and so on.
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公开(公告)号：EP1679370A1
公开(公告)日：2006-07-12
申请号：EP04773354.8
申请日：2004-09-15
IPC分类号： C12N15/09 , C12Q1/68 , C12Q1/02 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , G01N33/15 , G01N33/50
CPC分类号： G01N33/57496 , C12Q1/6827 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2523/125
摘要： The present invention relates to a method for assessing a cancerous state of a mammal-derived specimen, which comprises:
(1) a first step of measuring a methylation frequency of Fibrillin2 gene contained in a mammal-derived specimen or an index value having the correlation therewith, and
(2) a second ,step of determining a cancerous state of the specimen based on a difference obtained by comparing the measured methylation frequency or the index value having the correlation therewith, with a control; and the like.摘要翻译： 本发明涉及哺乳动物来源标本的癌症状态的评估方法，其包括：（1）测定哺乳动物来源标本中含有的原纤维蛋白2基因的甲基化频率或具有相关性的指标值的第一步骤 （2）第二步骤，基于通过将所测量的甲基化频率或与其具有相关性的指标值进行比较而获得的差异与对照确定样本的癌症状态的步骤; 等等。
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公开(公告)号：EP1679371B8
公开(公告)日：2012-10-24
申请号：EP04773361.3
申请日：2004-09-15
CPC分类号： G01N33/5011 , C12Q1/6827 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2523/125
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