公开(公告)号：EP3434270A1

公开(公告)日：2019-01-30

申请号：EP18189805.7

申请日：2010-06-11

申请人： Sunovion Pharmaceuticals Inc.

发明人： Giovinazzo, Anthony John ,  Hedden, David Bruce ,  de Somer, Marc L. ,  Bryson, Nathan John

IPC分类号： A61K31/473 ,  A61K31/44 ,  A01N43/42 ,  A61K47/02 ,  A61P15/10 ,  A61P25/16

摘要： The present invention relates to a pharmaceutical composition in unit dosage form formulated for sublingual administration, wherein said unit dosage form has a first portion comprising apomorphine particles comprising an acid addition salt of apomorphine and a second portion comprising a pH neutralizing agent, wherein the unit dosage from comprises a polymer selected from carboxymethylcellulose, cellulose acetate, ethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, nitrocellulose, polyoxyethylene/polyoxypropylene polymers, copolymers or block copolymers, polyvinylpyrrolidone polymers or derivatives, gums and combinations thereof.

公开(公告)号：EP2952191B1

公开(公告)日：2018-08-22

申请号：EP15175258.1

申请日：2010-06-11

申请人： Sunovion Pharmaceuticals Inc.

发明人： Giovinazzo, Anthony John ,  Hedden, David Bruce ,  de Somer, Marc L. ,  Bryson, Nathan John

IPC分类号： A61K31/473 ,  A61K31/44 ,  A01N43/42 ,  A61K47/02 ,  A61P15/10 ,  A61P25/16

CPC分类号： A61K31/485 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/06 ,  A61K9/2086 ,  A61K9/7007 ,  A61K31/473 ,  A61K47/02 ,  A61K47/10 ,  A61K47/183 ,  A61P15/10 ,  A61P25/16 ,  Y10T428/2982

摘要： The invention features sublingual formulations of apomorphine and apomorphine prodrugs, and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith.