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公开(公告)号：EP3074394B1
公开(公告)日：2019-02-20
申请号：EP14866384.2
申请日：2014-11-27
发明人： REN, Qingyun , LIU, Xinchang , ZOU, Zhifu , YAN, Guanghua , BI, Mingchao , GOLDMANN, Siegfried , ZHANG, Yingjun
IPC分类号： C07D417/04 , C07D417/14
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2.发明公开COMPLEXES AND SALTS OF DIHYDROPYRIMIDINE DERIVATIVES AND THEIR APPLICATION IN PHARMACEUTICALS 审中-公开二氢嘧啶衍生物的配合物和盐及其在制药中的应用
公开(公告)号：EP3253751A1
公开(公告)日：2017-12-13
申请号：EP16746121.9
申请日：2016-02-01
发明人： REN, Qingyun , CHEN, Liang , LIU, Xinchang , LIANG, Jinsheng , WU, Chenliang , ZOU, Zhifu , YAN, Guanghua , HUANGFU, Desheng , GOLDMANN, Siegfried , ZHANG, Yingjun
IPC分类号： C07D417/14 , A61K31/5377 , A61P31/12 , A61P31/20 , A61P1/16 , A61P35/00
CPC分类号： C07D417/14
摘要： This invention relates to L-tartaric acid complexes, acid addition salts, base addition salts of the compound named (S)-4-(((R)-6-(2-chloro-4-fluorophenyl) -5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyri midin-4-yl) methyl) morpholine-3-carboxylic acid or tautomer thereof and pharmaceutical compositions thereof, and further relates to use of the compounds or the pharmaceutical compositions in the manufacture of a medicament, especially for use in preventing, managing, treating or lessening a HBV infection. The complex, acid addition salt or base addition salt of the present invention is crystalline form, substantially crystalline form, polymorphism, amorphism, hydrate or solvate.
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3.发明授权
公开(公告)号：EP3253751B1
公开(公告)日：2020-12-09
申请号：EP16746121.9
申请日：2016-02-01
发明人： REN, Qingyun , CHEN, Liang , LIU, Xinchang , LIANG, Jinsheng , WU, Chenliang , ZOU, Zhifu , YAN, Guanghua , HUANGFU, Desheng , GOLDMANN, Siegfried , ZHANG, Yingjun
IPC分类号： C07D417/14 , A61K31/5377 , A61P31/12 , A61P31/20 , A61P1/16 , A61P35/00
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公开(公告)号：EP3697792A1
公开(公告)日：2020-08-26
申请号：EP18868606.7
申请日：2018-10-17
IPC分类号： C07D487/04 , A61K31/4985 , A61P31/20
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公开(公告)号：EP4251626A1
公开(公告)日：2023-10-04
申请号：EP21897219.8
申请日：2021-11-30
发明人： REN, Qingyun , LIU, Xinchang , ZHANG, Yingjun , YAN, Guanghua
IPC分类号： C07D487/04 , A61K31/506 , A61P1/16 , A61P35/00 , A61P31/20
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公开(公告)号：EP3694856A1
公开(公告)日：2020-08-19
申请号：EP18810716.3
申请日：2018-06-02
发明人： LIU, Xinchang , REN, Qingyun , HUANG, Jianzhou , XIONG, Zhimin , XIONG, Jinfeng , LI, You , LIU, Yang , ZOU, Zhifu , YAN, Guanghua , GOLDMANN, Siegfried , ZHANG, Yingjun
IPC分类号： C07D471/04 , C07D455/06 , A61K31/435 , A61K31/4375 , A61K31/5025 , A61P31/12 , A61P31/20
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7.发明公开PROCESSES FOR PREPARING DIHYDROPYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF 审中-公开VERFAHREN ZUR HERSTELLUNG VON DIHYDROPYRIMIDIN-DERIVATEN UND ZWISCHENPRODUKTEN DAVON
公开(公告)号：EP3074394A1
公开(公告)日：2016-10-05
申请号：EP14866384.2
申请日：2014-11-27
发明人： REN, Qingyun , LIU, Xinchang , ZOU, Zhifu , YAN, Guanghua , BI, Mingchao , GOLDMANN, Siegfried , ZHANG, Yingjun
IPC分类号： C07D417/04
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention relates to processes for preparing a dihydropyrimidine derivative having Formula (I) or a tautomer thereof having Formula (Ia), as well as a intermediate thereof. The processes of the invention have simple operation, high optical purity of product, high yield and convenient work-up, which is suitable for industrial production.
摘要翻译： 本发明涉及制备具有式（I）的二氢嘧啶衍生物或其具有式（Ia）的互变异构体的方法及其中间体。 本发明方法操作简单，产品光学纯度高，产量高，加工方便，适用于工业生产。
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