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公开(公告)号：EP3074392B1
公开(公告)日：2019-04-03
申请号：EP14865452.8
申请日：2014-11-27
发明人： REN, Qingyun , LIU, Xinchang , ZOU, Zhifu , TU, Linjin , SHAN, Yuefeng , LEI, Douxing , GOLDMANN, Siegfried , ZHANG, Yingjun
IPC分类号： C07D417/04 , C07D417/14
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公开(公告)号：EP3074394B1
公开(公告)日：2019-02-20
申请号：EP14866384.2
申请日：2014-11-27
发明人： REN, Qingyun , LIU, Xinchang , ZOU, Zhifu , YAN, Guanghua , BI, Mingchao , GOLDMANN, Siegfried , ZHANG, Yingjun
IPC分类号： C07D417/04 , C07D417/14
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3.发明公开COMPLEXES AND SALTS OF DIHYDROPYRIMIDINE DERIVATIVES AND THEIR APPLICATION IN PHARMACEUTICALS 审中-公开二氢嘧啶衍生物的配合物和盐及其在制药中的应用
公开(公告)号：EP3253751A1
公开(公告)日：2017-12-13
申请号：EP16746121.9
申请日：2016-02-01
发明人： REN, Qingyun , CHEN, Liang , LIU, Xinchang , LIANG, Jinsheng , WU, Chenliang , ZOU, Zhifu , YAN, Guanghua , HUANGFU, Desheng , GOLDMANN, Siegfried , ZHANG, Yingjun
IPC分类号： C07D417/14 , A61K31/5377 , A61P31/12 , A61P31/20 , A61P1/16 , A61P35/00
CPC分类号： C07D417/14
摘要： This invention relates to L-tartaric acid complexes, acid addition salts, base addition salts of the compound named (S)-4-(((R)-6-(2-chloro-4-fluorophenyl) -5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyri midin-4-yl) methyl) morpholine-3-carboxylic acid or tautomer thereof and pharmaceutical compositions thereof, and further relates to use of the compounds or the pharmaceutical compositions in the manufacture of a medicament, especially for use in preventing, managing, treating or lessening a HBV infection. The complex, acid addition salt or base addition salt of the present invention is crystalline form, substantially crystalline form, polymorphism, amorphism, hydrate or solvate.
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公开(公告)号：EP2900664B1
公开(公告)日：2017-12-13
申请号：EP13841041.0
申请日：2013-09-27
发明人： ZHANG, Yingjun , REN, Qingyun , LIU, Xinchang , WANG, Chaolei , WANG, Tianming , GOLDMANN, Siegfried
IPC分类号： C07D417/04 , A61K31/506 , A61P31/12
CPC分类号： C07D417/04
摘要： The present invention relates to crystalline forms of dihydropyrimidine derivatives, and pharmaceutical compositions comprising the crystalline forms disclosed herein, which may be used for preventing, managing, treating or lessening the severity of a viral disease in a patient, especially hepatitis B infection or a disease caused by hepatitis B infection.
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公开(公告)号：EP3074393B1
公开(公告)日：2018-08-15
申请号：EP14865774.5
申请日：2014-11-27
发明人： LIU, Xinchang , REN, Qingyun , ZOU, Zhifu , LIANG, Jinsheng , TU, Linjin , GOLDMANN, Siegfried , ZHANG, Yingjun
IPC分类号： C07D417/04 , C07D417/14
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention relates to processes for preparing a dihydropyrimidine derivative having Formula (I) or a tautomer thereof having Formula (Ia), as well as a intermediate thereof. The processes of the invention have simple operation, high optical purity of product, high yield and convenient work-up, which is suitable for industrial production.
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6.发明授权
公开(公告)号：EP2730572B1
公开(公告)日：2015-09-16
申请号：EP12811420.4
申请日：2012-07-09
发明人： ZHANG, Jiancun , ZHANG, Yingjun , XIE, Hongming , REN, Qingyun , LUO, Huichao , YU, Tianzhu , TAN, Yumei
IPC分类号： C07D403/14 , C07D405/14 , C07D401/14 , C07D409/14 , C07D471/04 , A61K31/4178 , A61K31/4439 , A61K31/438 , A61K31/4184 , A61K31/4745 , A61P1/16 , A61P31/14
CPC分类号： C07K5/06052 , A61K38/05 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04
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公开(公告)号：EP2900664A1
公开(公告)日：2015-08-05
申请号：EP13841041.0
申请日：2013-09-27
发明人： ZHANG, Yingjun , REN, Qingyun , LIU, Xinchang , WANG, Chaolei , WANG, Tianming , GOLDMANN, Siegfried
IPC分类号： C07D417/04 , A61K31/506 , A61P31/12
CPC分类号： C07D417/04
摘要： The present invention relates to crystalline forms of dihydropyrimidine derivatives, and pharmaceutical compositions comprising the crystalline forms disclosed herein, which may be used for preventing, managing, treating or lessening the severity of a viral disease in a patient, especially hepatitis B infection or a disease caused by hepatitis B infection.
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8.发明公开DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS 有权2,4,5,6-取代3,6-二氢嘧啶衍生物乙肝病毒（HBV）聚合酶抑制剂zur Behandlung von chronischer hepatitis
公开(公告)号：EP2888241A1
公开(公告)日：2015-07-01
申请号：EP13830553.7
申请日：2013-08-23
IPC分类号： C07D401/00 , C07D401/14 , C07D401/04 , C07D413/14 , C07D417/14 , C07D409/14 , C07D407/14 , C07D405/14 , C07D403/14 , A61K31/506 , A61K31/505 , A61P31/12
CPC分类号： C07D417/14 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/14 , A61K2300/00
摘要： Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically,provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases.
摘要翻译： 本文提供二氢嘧啶化合物及其药物应用，特别是用于治疗和预防HBV疾病。 具体地，本文提供了具有式（I）或（Ia）的化合物或其对映体，非对映异构体，互变异构体，水合物，溶剂合物或其药学上可接受的盐，其中式的变量如 规范。 本文还提供了具有式（I）或（Ia）的化合物或其对映体，非对映异构体，互变异构体，水合物，溶剂合物或其药学上可接受的盐在治疗和预防HBV疾病中的用途。
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公开(公告)号：EP3856740A1
公开(公告)日：2021-08-04
申请号：EP19865315.6
申请日：2019-09-27
发明人： HUANG, Jianzhou , REN, Qingyun , XIONG, Jinfeng , LIU, Yang , ZHANG, Yingjun
IPC分类号： C07D471/04 , A61K31/395 , A61P31/12 , A61P31/20
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10.发明授权
公开(公告)号：EP3253751B1
公开(公告)日：2020-12-09
申请号：EP16746121.9
申请日：2016-02-01
发明人： REN, Qingyun , CHEN, Liang , LIU, Xinchang , LIANG, Jinsheng , WU, Chenliang , ZOU, Zhifu , YAN, Guanghua , HUANGFU, Desheng , GOLDMANN, Siegfried , ZHANG, Yingjun
IPC分类号： C07D417/14 , A61K31/5377 , A61P31/12 , A61P31/20 , A61P1/16 , A61P35/00
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