公开(公告)号：EP1465740A1

公开(公告)日：2004-10-13

申请号：EP02796018.6

申请日：2002-12-20

申请人： SurModics, Inc.

发明人： CHAPPA, Ralph A. ,  STUCKE, Sean M. ,  AMOS, Richard A. ,  EVERSON, Terrence P. ,  CHUDZIC, Stephen J. ,  SWAN, Dale G. ,  DUQUETTE, Peter H.

IPC分类号： B05D1/36 ,  B05D3/06 ,  B05D1/00 ,  C07C309/42 ,  A61L29/00 ,  A61L31/00 ,  C08F2/26

CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a performed, and particularly a porous, polymeric substrate. The method includes the steps of a)- providing a porous support surface, b)- providing a nonpolymeric grafting reagent comprising a photoinitator group, c)- providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d)- applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.