公开(公告)号：EP1465740A1

公开(公告)日：2004-10-13

申请号：EP02796018.6

申请日：2002-12-20

申请人： SurModics, Inc.

发明人： CHAPPA, Ralph A. ,  STUCKE, Sean M. ,  AMOS, Richard A. ,  EVERSON, Terrence P. ,  CHUDZIC, Stephen J. ,  SWAN, Dale G. ,  DUQUETTE, Peter H.

IPC分类号： B05D1/36 ,  B05D3/06 ,  B05D1/00 ,  C07C309/42 ,  A61L29/00 ,  A61L31/00 ,  C08F2/26

CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a performed, and particularly a porous, polymeric substrate. The method includes the steps of a)- providing a porous support surface, b)- providing a nonpolymeric grafting reagent comprising a photoinitator group, c)- providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d)- applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

公开(公告)号：EP1069916B1

公开(公告)日：2006-05-10

申请号：EP99909955.9

申请日：1999-03-11

申请人： SurModics, Inc.

发明人： GUIRE, Patrick, E. ,  ANDERSON, Aron, B. ,  AMOS, Richard, A. ,  EVERSON, Terrence, P. ,  DUQUETTE, Peter H.

IPC分类号： A61K47/48 ,  A61L27/00

CPC分类号： A61K31/12 ,  A61K31/74 ,  A61K47/6957 ,  A61L27/227 ,  A61L27/34 ,  A61L27/507 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0082

摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.