公开(公告)号：EP4400498A1

公开(公告)日：2024-07-17

申请号：EP22866634.3

申请日：2022-09-07

申请人： Suzhou Kintor Pharmaceuticals, Inc.

发明人： TONG, Youzhi ,  DENG, Chun

IPC分类号： C07D401/14 ,  A61K31/4164 ,  A61K31/4439 ,  A61P17/10 ,  A61P17/14 ,  A61P11/06 ,  A61P35/00 ,  A61P35/02 ,  A61P3/10 ,  A61P9/12

CPC分类号： A61K31/4164 ,  A61K31/4439 ,  A61K38/05 ,  A61K38/15 ,  A61P1/00 ,  A61P1/02 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P5/28 ,  A61P7/04 ,  A61P7/06 ,  A61P9/00 ,  A61P9/12 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P15/08 ,  A61P17/10 ,  A61P17/14 ,  A61P21/00 ,  A61P25/00 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P43/00 ,  C07D401/14 ,  C07K1/30 ,  C07K5/06017 ,  C07K11/00

摘要： The present invention relates to amorphous substances, crystals, pharmaceutical compositions, preparation methods and uses of a thiohydantoin compound or pharmaceutically acceptable salt thereof. Specifically, provided are an amorphous substance of a compound of formula I, 1,5-naphthalene disulfonate thereof, an amorphous substance and two crystals (having crystal form A and crystal form B, respectively) of the 1,5-naphthalene disulfonate thereof, and corresponding pharmaceutical compositions, as well as preparation methods for the products above and corresponding pharmaceutical uses.