公开(公告)号：EP4455133A1

公开(公告)日：2024-10-30

申请号：EP22910146.4

申请日：2022-12-22

申请人： Suzhou Kintor Pharmaceuticals, Inc.

发明人： YANG, Zhaohui ,  LIU, Songying ,  PAN, Jie ,  CHEN, Dong ,  XU, Ruo ,  MA, Liandong ,  TONG, Youzhi

IPC分类号： C07D401/14 ,  A61K31/4035 ,  A61K31/444 ,  A61K31/4427 ,  A61K31/4545 ,  A61K31/4523 ,  A61K31/506 ,  A61K31/515 ,  A61K31/4188 ,  A61K31/4196 ,  A61K31/343 ,  A61K31/517 ,  A61P35/00 ,  A61P31/00 ,  A61P31/18 ,  A61P31/14 ,  A61P31/20 ,  A61P37/00

摘要： Provided is a multi-protein degradation agent having an imide skeleton, which can degrade multiple proteins comprising c-Myc, GSPT1, CK1α and IKZF (1/2/3) proteins, and therefore can be used for treating diseases or disorders related thereto, such as cancer.