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    USE OF (+)-2-BORNEOL IN PREPARATION OF DRUG FOR PROMOTING UPREGULATION OF EXPRESSION OF SPHINGOSINE KINASE-1 AND/OR BDNF
    1.
    发明公开
    USE OF (+)-2-BORNEOL IN PREPARATION OF DRUG FOR PROMOTING UPREGULATION OF EXPRESSION OF SPHINGOSINE KINASE-1 AND/OR BDNF 审中-公开

    公开(公告)号：EP3578174A1

    公开(公告)日：2019-12-11

    申请号：EP17916830.7

    申请日：2017-07-07

    申请人： Suzhou Pharmavan Cancer Research Center Co., Ltd.

    发明人： LI, Yunsen ,  DENG, Shiping ,  LI, Yong ,  JIANG, Chuanliang ,  YU, Yunhui

    IPC分类号： A61K31/045 ,  A61P25/28

    摘要： Disclosed is the use of (+)-2-borneol in the preparation of a drug for promoting the upregulation of the expression of sphingosine kinase-1 and/or BDNF (a brain-derived neurotrophic factor). Herein, (+)-2-borneol can be used to prepare a drug for promoting the upregulation of the expression of the sphingosine kinase-1 and/or the brain-derived neurotrophic factor. The drug can induce astrocyte spreading and migration, oligodendrocyte differentiation and survival, and neurite growth and nerve regeneration, and can promote the upregulation of the expression of the brain-derived neurotrophic factor, promote the survival of neurons and the growth of axons, inhibit the expansion of the infarct volume, and achieve the effect of repairing damage at the site of an immediate injury while preventing further expansion of the infarct area to completely treat brain damage, so that the long-term therapeutic effect thereof is significantly improved.