公开(公告)号：EP3733209A1

公开(公告)日：2020-11-04

申请号：EP20164714.6

申请日：2015-10-05

申请人： Synaffix B.V.

发明人： Verkade, Jorge Merijn Mathieu ,  Wijdeven, Maria Antonia ,  van de Sande, Petrus Josephus Jacobus Maria ,  van Berkel, Sander Sebastiaan ,  van Delft, Floris Louis

IPC分类号： A61K47/68 ,  A61P35/00

摘要： The present invention relates to a compound comprising an alpha-end and an omega-end, the compound comprising on the alpha-end a reactive group Q 1 capable of reacting with a functional group F 1 present on a biomolecule and on the omega-end a target molecule, the compound further comprising a group according to formula (1) or a salt thereof:

Said compound may also be referred to as a linker-conjugate. The invention also relates to a process for the preparation of a bioconjugate, the process comprising the step of reacting a reactive group Q 1 of a linker-conjugate according to the invention with a functional group F 1 of a biomolecule. The invention further relates to a bioconjugate obtainable by the process according to the invention.